Notice of Intent to Sole Source IN SILICHROM LTD 1.pdf

Synopsis No. 75N98026Q00190

Hospital and Laboratory Support Division

Office of Logistics and Operations (OLAO)

Office of Acquisition and Logistics Management (OALM)

Title: Genomic Regulatory Network of the Retina

Presolicitation

SYNOPSIS

General Information

Document Type: Presolicitation

Synopsis Number: 75N98026Q00190

Posted Date: April 09 2026

Original Response Date: April 19 2026

Current Response Date: April 19 2026

Set Aside: N/A

NAICS Code: 541990

Contracting Office Address

National Institutes of Health (NIH), Office of the Director (OD)

Office of Logistics and Operations (OLAO)

Office of Acquisition and Logistics Management (OALM)

Hospital and Laboratory Support Division

6701 Rockledge Drive

Bethesda, MD 20817

Description

INTRODUCTION

THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS

TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL

OR OPEN COMPETITION (INCLUDING BRAND-NAME).

The National Institutes of Health (NIH) intends to negotiate and award a contract without providing for full and open competition (Including brand-name) to:

IN SILICHROM LTD

15 DIGBY ROAD

NEWBURY

RG14 1TS, UNITED KINGDOM

NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE

The intended procurement is classified under NAICS code 541990 with a Size Standard $19.5M

REGULATORY AUTHORITY

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The resultant contract will include all applicable provisions and clauses in effect through the

Federal Acquisition Circular (FAC) 2005-99-1, July 16, 2018. This acquisition is conducted under the procedures as prescribed in FAR subpart 13-Simplified Acquisition Procedures at an amount not exceeding the simplified acquisition threshold ($350,000).

STATUTORY AUTHORITY

This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR)

Part 13-Simplified Acquisition Procedures, Subpart 13.106-1 (b) (1), Soliciting from a single source and is not expected to exceed the simplified acquisition threshold. Contracts awarded using

FAR Part 13-Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6-

Competition Requirements.

GENERAL INFORMATION

Title: Genomic Regulatory Network of the Retina

Background and Purpose

Precise gene expression patterns, which are critical for maintaining structure and function in the retinal cells, are controlled by regulatory networks that comprise of multiple levels including topology of the genome, regulatory sequences, transcription factors and signaling proteins. Next generation sequencing methods have now made it possible to perform genome-wide studies of gene expression, genetic variations and corresponding regulatory proteins. We are interested in elucidating the nature of gene regulatory networks during development and how these are disrupted in aging and disease to help us design novel treatment paradigms for blinding largely incurable retinal and macular degenerative diseases. A major goal of our research is to integrate diverse molecular genomic datasets on genome-wide gene expression with regulatory factor binding, topological information and other changes in the retina during normal development, aging and disease conditions in humans and mice. These networks will be used to explore genomic regulations in the retina and understand the effect of human genetic generations that are associated with retinal and macular degeneration

The contractor will pre-process diverse raw data generated in the lab by Next Generation

Sequencing methods as well as those from relevant public datasets. The contractor will integrate data using state-of-the-art statistical modeling.

The contractor will generate genomic regulatory networks from this data

- and will develop user-friendly tools to allow biologists to explore the data.

- The contractor will identify retina-specific genomic features and explore biological and medical significance.

- Finally, the contractor will attend regular meetings with the people involved in the project and participate in the publication of this work in peer-review journals.

- The draft of a manuscript ready for submission is expected by the end of the period of performance.

CLOSING STATEMENT

This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include a technical proposal, a cost-price proposal, the period of performance, the

Unique Entity ID (UEI), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management

(SAM) www.sam.gov.

A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purpose of determining whether to proceed on a non-competitive basis or to conduct competitive procurement.

All responses must be received by April 19 , 2026 at 9:00 AM Eastern time and must reference solicitation number 75N98026Q00190 Responses may be submitted electronically to Mr.

Vishnuvajjala Hanumanth Rao, Lead Purchasing agent at vishnuh@mail.nih.gov Fax responses will not be accepted.

"All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency.”

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