75N95023Q00663 23-005067 - Bruker PD_v3.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

1. Statement of Need and Purpose: The Neurophysiology Imaging Facility (NIF) core at

NIMH requires an upgrade to the 7T Bruker MRI scanner console housed in Building 49.

The current console (electronics, software) is more than 15 years old and will no longer be supported by Bruker starting in 2024. This Bruker console upgrade or equal system is therefore essential for the continuation of function of the 7T scanner.

2. Background Information and Objective: Magnetic resonance (MR) imaging is one of the most impressive tools of modern medicine, allowing for the visualization of normal and pathological tissues in the body. In no field has imaging impacted biomedical research more than in the study of the brain, in which MR allows one to visualize not only neural structures but also neural function. The Neurophysiology Imaging Facility

(NIF) is a centralized core facility that brings together a broad range of techniques to provide the most integrated and efficient study of brain physiology in nonhuman primates. The NIF core facility is an intramural resource shared by three institutes at the

National Institutes of Health (NIH) – National Institute of Mental Health (NIMH), National

Institute of Neurological Disorders and Store (NINDS), and National Eye Institute (NEI).

The NIF core staff, in collaboration with other researchers at NIH, develops methodologies to obtain high resolution anatomical animal MRI data. Several such collaborations have yielded excellent data, resulting in the publication of several peer-reviewed papers. NIF facility is among a handful of sites in the world with this type of leading-edge setup dedicated to animal model mental health research.

The 7 Tesla (7T) scanner is the main scanner used to perform MRI imaging of marmosets and is a critical element within the Neurophysiology Imaging Facility. The need to upgrade this scanner has been recognized for some time. The upgrade will incorporate a new generation of electronics and imaging capabilities. These improvements will greatly enhance the imaging capacities affecting a large and growing group of marmoset researchers across the NIH.

3. Generic Name of Product: 7 Tesla Magnetic Resonance Imaging spectrometer and console upgrade for Bruker Biospec 7/30 scanner or Equal.

4. Purchase Description:

Company: Bruker or Equal

Model: Console upgrade or Equal

BAP70/30U 1 PC - BioSpec 70/30 System Upgrade

5. Salient characteristics:

The essence of this purchase is to responsibly upgrade and extend the performance of the 7T Bruker scanner or to obtain an Equal new 7 Tesla MRI scanner. The scanner is highly utilized and is currently equipped with cutting edge components, such as custom-designed gradient and radiofrequency coils. Two 16-channel receive arrays, and many more multichannel arrays, are currently in use to support the scientific projects of multiple investigators in different institutes.

Any upgrade is offered, must be operationally compatible as well as provide a manufacturer-authorized service provider for the existing Bruker components that will remain with the 7T scanner and upgrade. This includes the magnet and magnet monitoring equipment, gradient, shims, gradient amplifiers and a number of radiofrequency coils. The upgrade must allow for a quick turnaround and a smooth transition with full and expanded functionality so that existing projects on the 7T scanner may continue to move forward. The scanning sequences must be immediately compatible with the newly upgraded console. The upgrade shall include applicable upgrades of the Bruker magnet monitoring unit, receivers, coils, licenses and frameworks, introduction, and training, and accessories.

If an Equal system is offered in accordance with FAR 52.211-6, which is included herein by reference, it must meet the following minimum salient characteristics:

a. The new console must be compatible with the existing PCI gradient amplifier, RRI gradient coils, third-party 16-channel receive arrays, and Bruker 7T/30 magnet.

b. The new console must be able to generate the RF and gradient waveform with temporal resolution no worse than 12.5ns and 1us. The noise figure of its receiver must be no worse than 1.4dB.

c. The software of the new console must be compatible with all current imaging sequences and protocols, like FLASH, RARE, MSME, MGE, EPI, UTE, ZTE, susceptibility-weighted reconstruction, GRAPPA reconstruction, flow-compensation preparation, inversion-recovery preparation, perfusion preparation, and diffusion preparation, and cardiac/respiration gating.

d. The software of the new console must implement dynamic B0 shimming, multi-slice excitation, FOV shifting in frequency-encoding direction of EPI, and variable flip-angle RARE.

6. Quantity: One (1) x Bruker BioSpec 70/30 System Upgrade or Equal system. Includes applicable upgrades of the Bruker magnet monitoring unit, receivers, coils, licenses and frameworks, introduction, and training, and accessories or Equal system.

7. Delivery Date: Approximately 6-9 months after the contract has been awarded.

Ship to:

49 Convent Drive

Bldg. 49, Room 3C84

Bethesda, Maryland 20892

8. Period of Performance: N/A

9. Option(s): None