D 75N95023Q00610-CSS.pdf

COMBINED SYNOPSIS / SOLICITATION

75N95023Q00610

TITLE: Screening Compounds Based on the Broad Institute Repurposing Set

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice.

This announcement constitutes the only solicitation; quotations are being requested and a written solicitation will not be issued.

(ii) The solicitation number is 75N95023Q00610 and the solicitation is issued as a request for quotation (RFQ). This acquisition is for a commercial item and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13 - Simplified Acquisition Procedures, FAR Part 13.5 – Simplified Procedures for Certain Commercial Products and Commercial Services, and FAR Part 12 - Acquisition of Commercial Items, and is expected to exceed the simplified acquisition threshold.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through

Federal Acquisition Circular (FAC) 2023-05 effective September 7, 2023.

(iv) The associated NAICS code is 325414 and the Small Business size standard is 1,250 employees. This requirement is full and open and no set aside restrictions are applicable.

DESCRIPTION

(v) The National Center for Advancing Translational Sciences (NCATS), within the National

Institutes of Health (NIH), requires a curated collection of screening compounds based on the Broad Institute Repurposing Set. These are highly optimized small molecules, FDA-approved drugs, clinical trial drugs, and pre-clinical tool compounds with a companion information resource. The entire set has more than 6,000 compounds and NCATS seeks to purchase a curated collection as large as possible based on this Broad Institute Repurposing Set.

NCATS requires a compound library based on the Broad Institute Repurposing Set, as large as possible but with a minimum of 6,000 compounds, that meet the following salient characteristics:

1) 500ul each @ 10mM

2) 96-well plate format

3) Small molecules must have validated biological and pharmacological activities.

4) Must be available for high-throughput screening (HTS) and high-content screening (HCS).

5) Must come with detailed biological and chemical information with LC/MS and NMR reports to ensure high quality.

6) Guaranteed to have a purity of >95% (accuracy +/-5%) that is to be confirmed by NMR and/or LCMS spectra.

Vendors able to provide at least 6,000 compounds will be considered for award.

(vi) The Government anticipates award of a firm, fixed-price purchase order and the anticipated delivery date is within three months after receipt of order. Delivery is to be made to the below city and state, FOB destination. The exact address will be noted on the purchase order.

Rockville, MD 20851

EVALUATION AND AWARD

(vii) The anticipated award date is September 18, 2023.

(viii) The Government plans to make an award resulting from this solicitation. The resulting award will be made to the responsible quoter whose quote conforming to the solicitation will be most advantageous to the Government, price and other factors considered, using comparative evaluations. The following factors shall be used to evaluate quotes:

1. Technical Capability.

a. The number of compounds to be provided that meet the salient characteristics, and

b. the delivery timeline.

2. Past Performance. Prior performance of contracts with similar requirements. The Government may use any source of available past performance information (see FAR 13.106- 2(b)(3)).

3. Price.

SUBMISSION INSTRUCTIONS

(ix) All responses to this RFQ must be received by 10:00am Eastern Time on Friday, September 15, 2023 and must reference the solicitation number cited above. Responses must be submitted in the English language via email to Kimberly Espinosa at kimberly.espinosa@nih.gov.

(x) This is an RFQ. This request does not commit the Government to pay any costs incurred in the preparation of the submission of this quotation or to contract for supplies or service.

Supplies are of domestic origin unless otherwise indicated by quoter. Any representations and/or certifications attached to this RFQ must be completed by the quoter.

mailto:kimberly.espinosa@nih.gov

(xi) Responses to this RFQ must include clear and convincing evidence of the quoter’s capability of fulfilling the requirement as it relates to the technical evaluation criteria. Responses may exceed capability or performance characteristics of the solicitation's requirements. The Government reserves the right, but is not required, to award to a response that exceeds capability or performance characteristics of the solicitation's requirements if it provides a benefit to the Government.

(xii) Responses must include the Unique Entity Identifier (UEI) (which recently replaced the DUNS number), the Taxpayer Identification Number (TIN), the certification of business size, and completed representations in FAR Provisions 52.225-6, 52.229-11, and 52.212-3 (all attached). If the quoter’s representations in the System for Award Management (SAM) are accurate, only Paragraph B of FAR Provision 52.212-3 should be completed.

(xiii) Responses must also include a quotation in U.S. dollars that includes:

1. The total price,

2. Individual prices for each item,

3. The proposed delivery date,

4. Prompt payment discount terms,

5. Product or catalog number(s),

6. Product description, and

7. Any other information or factors that may be considered in the award decision. Such factors may include: special features required for effective program performance; trade-in considerations; warranty considerations; maintenance availability; and environmental and energy efficiency considerations.

(xiv) If the awardee is an Other Than Small Business and the compound library is a domestic end product (the library is manufactured in the United States), the awardee will be required to submit an acceptable subcontracting plan prior to award.

(xv) For information about this RFQ, contact Kimberly Espinosa, Contracting Officer, at 301-827-

3546 or kimberly.espinosa@nih.gov.

(xvi) All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.

TERMS AND CONDITIONS, PROVISIONS, CLAUSES, AND REPRESENTATIONS

(xvii) FAR Provision 52.252-1, Solicitation Provisions Incorporated by Reference (Feb 1998).

This solicitation incorporates one or more solicitation provisions by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. The offeror is cautioned that the listed provisions may include blocks that must be completed by the offeror and submitted with its quotation or offer. In lieu of submitting the full text of those provisions, the offeror may identify the provision by paragraph identifier and provide the appropriate information with its quotation or offer. Also, the full text of a solicitation provision may be accessed electronically at www.acquisition.gov.

The following provisions apply to this acquisition and are incorporated by reference:

1. FAR Provision 52.204-7, System for Award Management (Oct 2018)

2. FAR Provision 52.204-16, Commercial and Government Entity Code Reporting (Aug 2020)

3. FAR Provision 52.212-3, Offeror Representations and Certifications—Commercial Products and Commercial Services (Sep 2023)

(xviii) FAR Clause 52.252-2, Clauses Incorporated by Reference (Feb 1998). This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed electronically at www.acquisition.gov.

In addition to the clauses checked in FAR 52.212-5 (attached), the following clauses also apply to this acquisition and are incorporated by reference:

1. FAR Clause 52.204-13, System for Award Management Maintenance (Oct 2018)

2. FAR Clause 52.204-18, Commercial and Government Entity Code Maintenance (Aug 2020)

3. FAR Clause 52.212-4, Contract Terms and Conditions – Commercial Products and

Commercial Services (Dec 2022)

4. HHSAR Clause 352.222-70, Contractor Cooperation in Equal Employment Opportunity

Investigations (December 18, 2015)

(xix) One or more of the items under this acquisition is subject to the World Trade Organization Government Procurement Agreement and Free Trade Agreements.

(xx) The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement.

(xxi) Post-Award Evaluation of Contractor Performance. Interim and Final evaluations of

Contractor performance will be prepared on task orders in accordance with FAR Subpart

42.15. Performance evaluations will not be prepared on the parent IDIQ contract.

Interim and Final evaluations will be provided to the Contractor as soon as practicable after completion of the evaluation. The Contractor will be permitted fourteen days to review the document and to submit additional information or a rebutting statement. If agreement cannot be reached between the parties, the matter will be referred to an individual one level above the Contracting Officer, whose decision will be final. Copies of the evaluations, Contractor responses, and review comments, if any, will be retained as part of the contract file, and may be used to support future award decisions.

Contractors may access evaluations through a secure Web site for review and comment at the following address: http://www.cpars.gov.

http://www.cpars.gov/

ATTACHMENTS

(xxii) The following terms, provisions, and clauses are incorporated and attached in full text:

1. FAR provision 52.212-1, Instructions to Offerors – Commercial Products and Commercial Services (Sep 2023) (Tailored)

2. FAR Provision 52.225-6, Trade Agreements Certificate (Feb 2021)

3. FAR Provision 52.229-11, Tax on Certain Foreign Procurements—Notice and

Representation (Jun 2020)

4. FAR Provision 52.212-3, Offeror Representations and Certifications—Commercial Products and Commercial Services (Sep 2023)

5. FAR Clause 52.212-5, Contract Terms and Conditions Required to Implement Statutes or

Executive Orders–Commercial Products and Commercial Services (Sep 2023)

6. Invoice and Payment Provisions with IPP (March 21, 2023)