Amnd 01-s.pdf

(x)

75N95022Q00446 x x copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted ; or (c) By separate letter or electronic communication which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE

RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR

OFFER. If by virtue of this amendment you desire to change an offer already submitted , such change may be made by letter or electronic communication, provided each letter or electronic communication makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

NINDS

Bethesda, MD 20892-7511 Disorders and Stroke National Institute of Neurological National Institutes of Health

09/09/20220001

13. THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS. IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

12. ACCOUNTING AND APPROPRIATION DATA (If required) is not extended.

Items 8 and 15, and returning

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended , by one of the following methods: (a) By completing

The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

FACILITY CODE CODE

10B. DATED (SEE ITEM 13)

10A. MODIFICATION OF CONTRACT/ORDER NO.

9B. DATED (SEE ITEM 11)

9A. AMENDMENT OF SOLICITATION NO.

CODE

8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)

7. ADMINISTERED BY (If other than Item 6)CODE 6. ISSUED BY

PAGE OF PAGES

4. REQUISITION/PURCHASE REQ. NO.3. EFFECTIVE DATE2. AMENDMENT/MODIFICATION NO. 5. PROJECT NO. (If applicable)

1. CONTRACT ID CODE

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

09/06/2022

CHECK ONE A. THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT

B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

D. OTHER (Specify type of modification and authority) appropriation data, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

E. IMPORTANT: Contractor is not is required to sign this document and return __________________ copies to the issuing office.

ORDER NO. IN ITEM 10A.

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)

The purpose of this Amendment is to: 1) Extend the quotation submission due date to September 13, 2022 at 5:00 PM ET and 2) Amend the Purchase Description.

Please see the continuing pages for more information.

16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)15A. NAME AND TITLE OF SIGNER (Type or print)

15C. DATE SIGNED 16B. UNITED STATES OF AMERICA 15B. CONTRACTOR/OFFEROR 16C. DATE SIGNED

(Signature of person authorized to sign) (Signature of Contracting Officer)

STANDARD FORM 30 (REV. 11/2016)

Prescribed by GSA FAR (48 CFR) 53.243

Previous edition unusable

Except as provided herein, all terms and conditions of the document referenced in Item 9 A or 10A, as heretofore changed, remains unchanged and in full force and effect .

is extended.x x

Evan C. Feely

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

Brand Name or Equal: Neurostar Drill and Injection Micro-robot for Performing Intracranial Injections in Mice

National Institute for Neurological Disorders and Stroke, Cellular Neurophysiology Section

1. Statement of Need and Purpose: The National Institutes of Health (NIH) requires a automated stereotaxic injection system that is brand name or equal to the Neurostar Drill and Injection Micro-robot. This equipment will be used to perform intracranial injections and to make cranial windows into mouse brains. The experiments being perfromed will directly test the effects of alterations in neural circuitry in various animal models of Parkinson’s Disease.

2. Background Information and Objective: The NIH is an agency of the Department of

Health and Human Services and the Federal focal point for health research. Its mission is to seek fundamental knowledge about the nature and behavior of living systems and apply that knowledge to enhance health, lengthen life, and reduce illness and disability.

The National Institute for Neurological Disorders and Stroke (NINDS), which is an Institute within the NIH, seeks to reduce the burden of neurological disease through supporting and conducting basic, translational, and clinical research on the healthy and diseased nervous system, fostering the training of investigators in the basic and clinical neurosciences, and seeking better understanding, diagnosis, treatment, and prevention of neurological disorders.

The NINDS Cellular Neurophysiology Section is conducting research into how basal ganglia and midbrain dopamine circuits are altered in animal models of Parkinson’s Disease. To generate the Parkinson’s disease model, NINDS will express alpha synuclein in midbrain dopamine neurons; alpha synuclein is a protein that has been associated with cell death among dopamine neurons. This injection process will involve performing intracranial injections in mice. To precisely target the midbrain dopamine neurons through manual use of an injection needle requires substantial experience and can occur with variable success between animals. However, using a robot guided injection method will allow NINDS to more consistently target its brain structures of interest. Therefore, this is an essential piece of equipment for NINDS’ experiments.

3. Product Information:

• Brand Name or Equal Benchmark: Drill & Microinjection Robot (Mouse) including Drill Autostop Function

• Brand Name Manufacturer: Neurostar GmbH - Kähnerweg 1, Tübingen, 72072, Germany

• Generic Name of Product: Automated stereotaxic injection system

• Product Description: Allows for automated drilling and precise injections into mouse brain tissue without tool exchange

4. Salient characteristics:

Any brand name or equal items that are proposed must equal or exceed the following salient physical, functional, and performance characteristics:

• Interconnected automated drill and microinjection robot (mouse), which includes:

o Robot stereotaxic system with atlas integration o Motorized drill & microinjection module o Full control by the robot stereotaxic software o Full integrated stereotaxic atlas o Zeroing at Lambda/Bregma, correction for tilt errors o Individual atlas scaling o Drill autostop function o Automated drilling procedure without damaging the underlying brain tissue o High accuracy positioning of Burr Hole with depth control o No requirement for tool exchange after drilling o Use of Bregma-related coordinates o User defined injection rates o Real-time atlas-based visualization of syringe tip and injection sites o Compatibility with Microsoft Windows 10

• Drill automated craniotomy function

• Automated synchronization device for cannula and drill bit o Must allow automated synchronization between the drill and syringe o Must allow for optical detection of the drill bit and the syringe needle

• Software integration and holder o Must allow for synchronized Drill/Injection/Cannula implantation procedure o Must provide real-time atlas-based visualization of cannula tip o Must include holder for fiber optic ferrules

• Remote Control for robot stereotaxic

• Mouse heating pad with integrated wireless closed-loop controller o Full integration in the robot stereotaxic control software o Real-time display of temperature, heating state, running state o High precision temperature control, resolution of 0.1℃, set range of 20-

45℃

• Mouse Gas Anesthesia Head Holder

• Non-Rupture Ear Bars (Mouse) o 60° Non-Rupture tip

5. Quantity: One system, with all required components

6. Delivery Terms: Contractor shall deliver all equipment within 30 days after receipt of order to NIH Building 35, Room 3C-1002, 35 Convent Drive, Bethesda, MD 20892- 3700. This shall be done in coordination with the Contracting Officer’s Representative (COR). Delivery must be FOB destination and include inside delivery. Contractor must also conduct a virtual session with Government personnel within two weeks of delivery to provide step-by-step instructions for equipment assembly.

7. Warranty Terms: Contractor shall warrant its equipment against defects in material, fabrication, or workmanship for a minimum of 12 months from the date the Government accepts delivery of the items.