D 75N95022Q00363-CSS-Amendment 1.pdf

COMBINED SYNOPSIS / SOLICITATION

75N95022Q00363

TITLE: Small Molecules Library for NCATS ETB Pre-Clinical Library

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice.

This announcement constitutes the only solicitation; quotations are being requested and a written solicitation will not be issued.

(ii) The solicitation number is 75N95022Q00363 and the solicitation is issued as a request for quotation (RFQ). This acquisition is for a commercial item and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13 - Simplified Acquisition Procedures, FAR Part 13.5 - Simplified Procedures for Certain Commercial Products and Commercial Services, and FAR Part 12 - Acquisition of Commercial Items, and is expected to exceed the simplified acquisition threshold.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through

Federal Acquisition Circular (FAC) 2022-07 effective August 10, 2022.

(iv) The associated NAICS code is 325414 and the Small Business size standard is 1,250 employees. This requirement is set aside exclusively for Small Business.

DESCRIPTION

(v) A wealth of knowledge is obtained from screening a diverse collection of chemical compounds.

It provides the starting point of all information for medicinal chemistry’s structure-activity relationship (SAR) design to synthesize novel compounds that have more desirable properties.

A diverse and novel screening collection provides the backbone of NCATS’ operation and is imperative for translational sciences to obtain effective small molecules with on-target effects.

The Early Translation Branch (ETB) within the National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) requires a library of specific compounds. The addition of these compounds would increase the diversity of NCATS’ chemical libraries and allow a more thorough and effective SAR expansion by the medicinal chemist.

See Attachments 1 and 2 for the complete list of compounds, quantities, salient characteristics, CAS numbers, and SMILES.

Vendors may submit a quote for as many of the listed compounds as they are able to provide that meet all salient characteristics.

It is imperative that the library consist of compounds with the same level of purity and same biological functionality and therefore all quoted compounds must be manufactured by the same vendor. However, the vendor may work with a subcontractor to complete the chemical synthesis as long as all salient characteristics are met and the compounds have the requisite purity.

(vi) The anticipated delivery date is within six (6) months after receipt of order. Quoters may propose an alternative delivery date. The compounds shall be delivered to the below city / state, FOB Destination. The exact address and point of contact will be included on the resultant award.

Rockville, MD 20850

EVALUATION AND AWARD

(vii) The anticipated award date is September 14, 2022.

(viii) The Government plans to make one (1) firm, fixed-price award resulting from this solicitation.

The resulting award will be made to the vendor who represents the best value to the Government, price and other factors considered. The Government will use a trade-off approach and comparative evaluations to determine which quotation represents the best value, in consideration of the following evaluation criteria:

1. Technical Capability: The number of compounds able to be provided that meet all salient characteristics, and the proposed delivery date.

2. Past Performance: Past performance providing similar items. The Government may use any source of available past performance information (see FAR 13.106-2(b)(3)).

3. Price: The total price for all items, including shipping.

SUBMISSION INSTRUCTIONS

(ix) All responses to this RFQ must be received by 12:00pm Eastern Time on Thursday, September 8, 2022 and must reference the solicitation number cited above. Responses must be submitted via email to Kimberly Espinosa at kimberly.espinosa@nih.gov.

(x) This is an RFQ. This request does not commit the Government to pay any costs incurred in the preparation of the submission of this quotation or to contract for supplies or service.

Supplies are of domestic origin unless otherwise indicated by quoter. Any representations and/or certifications attached to this RFQ must be completed by the quoter.

(xi) Responses to this RFQ must include sufficient information to establish the interested parties’ bona-fide capabilities of providing the product or service. Responses may exceed capability or performance characteristics of the solicitation's requirements. The Government reserves the right, but is not required, to award to a response that exceeds capability or performance mailto:kimberly.espinosa@nih.gov characteristics of the solicitation's requirements if it provides a benefit to the Government.

(xii) Responses must be submitted in the English language and in U.S. dollars, and must include the Unique Entity Identifier (UEI) (which recently replaced the DUNS number), the Taxpayer Identification Number (TIN), the certification of business size, the completed representation in FAR Provision 52.229-11 (attached), and a quotation that includes:

1. The total price (including shipping)

2. Individual prices for each listed line item

3. Delivery days after contract award for the submission of all compounds. Quoters shall confirm their ability to deliver the required compounds within six (6) months after receipt of order or shall propose an alternative delivery date.

4. Delivery terms

5. Prompt payment discount terms

6. Product or catalog number(s)

7. Product description

8. Any other information or factors that may be considered in the award decision. Such factors may include: special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations.

(xiii) For information about this RFQ, contact Kimberly Espinosa, Contracting Officer, at 301-827-

3546 or kimberly.espinosa@nih.gov.

(xiv) All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.

TERMS AND CONDITIONS, PROVISIONS, AND REPRESENTATIONS

(xv) The provision at FAR 52.252-1, Solicitation Provisions Incorporated by Reference (Feb

1998). This solicitation incorporates one or more solicitation provisions by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. The offeror is cautioned that the listed provisions may include blocks that must be completed by the offeror and submitted with its quotation or offer. In lieu of submitting the full text of those provisions, the offeror may identify the provision by paragraph identifier and provide the appropriate information with its quotation or offer. Also, the full text of a solicitation provision may be accessed electronically at www.acquisition.gov.

The following provisions apply to this acquisition and are incorporated by reference:

1. FAR Provision 52.204-7, System for Award Management (Oct 2018)

2. FAR Provision 52.204-16, Commercial and Government Entity Code Reporting (Aug 2020)

3. FAR Provision 52.212-3, Offeror Representations and Certifications—Commercial Products and Commercial Services (Nov 2021)

(xvi) The clause at FAR 52.252-2, Clauses Incorporated by Reference (Feb 1998). This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed electronically at www.acquisition.gov.

In addition to the clauses checked in FAR 52.212-5 (attached), the following clauses also apply to this acquisition and are incorporated by reference:

1. FAR Clause 52.204-13, System for Award Management Maintenance (Oct 2018)

2. FAR Clause 52.204-18, Commercial and Government Entity Code Maintenance (Aug 2020)

3. FAR Clause 52.212-4, Contract Terms and Conditions – Commercial Products and

Commercial Services (Nov 2021)

4. HHSAR Clause 352.222-70, Contractor Cooperation in Equal Employment Opportunity

Investigations (December 18, 2015)

ATTACHMENTS

(xvii) The following are incorporated and attached in full text:

1. List of Compounds

2. List of Compounds_SMILES

3. The provision at FAR 52.212-1, Instructions to Offerors – Commercial Products and

Commercial Services (Nov 2021) (Tailored)

4. The clause at FAR 52.212-5, Contract Terms and Conditions Required to Implement

Statutes or Executive Orders–Commercial Products and Commercial Services (May 2022)

5. NIH Electronic Invoice Submission Instructions without IPP (April 21, 2022)

6. FAR Provision 52.225-2, Buy American Certificate (Feb 2021)

7. FAR Provision 52.229-11, Tax on Certain Foreign Procurements—Notice and

Representation (Jun 2020)