2025-UWMSN-00869-RFB_-_SMALL_ANIMAL_7T_MRI_INSTRUMENT_Amended.pdf

1. General Information

1.1 Scope: Purchase of a Small Animal 7T MRI Instrument The instrument will be used for anatomical imaging, functional imaging, and molecular imaging studies of small animal models including (but not limited to) mice, rats, and marmosets. These imaging results will support research that investigates a variety of biological conditions and pathological diseases, including cancer, cardiovascular disease, neurological conditions, musculoskeletal diseases, metabolic diseases, and infectious diseases. The instrument will also be used for theragnostic research that combines diagnoses and therapy for cancer and other pathologies.

See Section 5 (Specifications) and Section 6 (Technical Specifications) for the minimum acceptable specifications for items/services desired. The University does not guarantee to purchase any specific quantity or dollar amount. The estimated item quantities identified in this Request for Bid are for bid purposes only.

1.2 Definitions:

The following definitions are used throughout this document:

- Agent means UW Purchasing Agent responsible for this Request for Bid.

- Bidder means a firm submitting a bid in response to this Request for Bid.

- Contractor means successful Bidder awarded the bid.

- CT means Central Time.

- DVB means Disabled Veteran-Owned Business.

- MBE means Minority Business Enterprise.

- Purchasing means the UW Purchasing department responsible for the procurement of goods and services.

- RFB means Request for Bid.

- Sourcing Module means the ShopUW+ Sourcing Event Module.

- State means State of Wisconsin.

- University and UW both mean University of Wisconsin-MADISON.

- WBE means Woman-Owned Business Enterprise.

1.3 eSupplier/VendorNet Registration:

Registration on the State of Wisconsin’s eSupplier Portal (eSupplier.wi.gov) is available free of charge to all businesses and organizations that want to sell to the state. Refer to Bidder Response: Registration and Sign-in Process for further instructions. Registration allows a vendor to:

• Register for a bidders list for commodities/services that the vendor wants to sell to the state.

• Receive an automatic e-mail notification each time a state agency, including the University of Wisconsin System campuses, posts a Request for Bid (RFB) or a Request for Proposal (RFP) with an estimated value over $50,000 in their designated commodity/service area(s).

• Receive an e-mail notification of addendums/amendments relative to the RFB or RFP.

Only vendors registered, with a valid e-mail address, at the time the RFB or RFP is posted will receive e-mail notifications of addendums/amendments. Vendors who obtain the RFB or RFP from a third party; through the public notice website;

or other means assume responsibility for checking for updates to the RFB or RFP.

NOTE: Registration with eSupplier/Vendornet does not register the bidder with the ShopUW+ Sourcing Event Module.

Instructions for registering with the Sourcing Module can be found here: Supplier Login or Join JAGGAER Supplier Network (sciquest.com)

1.4 Campus Delivery Requirements:

• Delivery of orders shall be made to University departments five days per week, Monday through Friday, during normal University business hours.

• Contractor shall follow the delivery requirements outlined by the ordering campus. Contact the ordering department or the Purchasing office for specific policy language, restrictions, and a campus map.

• Any unique delivery arrangements must be pre-approved by contacting the ordering department.

https://esupplier.wi.gov/psp/esupplier/SUPPLIER/ERP/h/?tab=WI_GUEST https://esupplier.wi.gov/starcontent/eSupplier/eSupplier%20-%20Registering%20as%20a%20Bidder.pdf https://solutions.sciquest.com/apps/Router/SupplierLogin?CustOrg=UWisconsin https://solutions.sciquest.com/apps/Router/SupplierLogin?CustOrg=UWisconsin

• The University of Wisconsin-Madison no longer permits access to trucks over 30 ft. in length on several designated streets on this campus. The exceptions are trucks necessary for the delivery or pick up of perishable commodities, private construction vehicles, vehicles carrying radioactive materials, and campus service vehicles.

For specific policy language, a campus map and restrictions, see the University Transportation Services website at http://transportation.wisc.edu/resources/large_truck.aspx.

• This contract requires that Contractor deliver goods to the stated delivery address in accordance with the 30’ truck policy referenced above. Any unique delivery arrangements must be pre-approved by contacting the ordering department or Material Distribution Services (MDS) at (608) 497-4432. MDS reserves the right to charge Contractor reasonable material handling fees for any deliveries they make for the Contractor.

1.5 Parking:

University parking is very limited. Each Contractor and/or Contractor employee(s) shall make their own arrangements for parking through the University’s transportation or the ordering department’s business office. No additional Contractor costs will be allowed for parking fees or violations. Unauthorized vehicles parking in University lots or loading docks without permits will be ticketed and/or towed.

1.6 Promotional Materials/Endorsement:

Contractor agrees that they will not use any promotional or marketing material which states expressly or implies that the University endorses either the Contractor or any party related to the Contractor or this Contract.

1.7 Energy Star:

The State encourages the use of equipment which meets the Environmental Protection Agency (EPA) Energy Star™ requirements. The Energy Star Program is a voluntary contract between an Original Equipment Manufacturer (OEM) and the EPA. It is not mandatory that every device offered under this bid meet Energy Star requirements, but the bulk of the product line should be energy efficient. Bidder should identify those items which meet the Energy Star requirements on the Bidder Response Sheet.

http://transportation.wisc.edu/resources/large_truck.aspx

2. RFB Process Instructions

2.1 Oral Presentations, Product Demonstrations and Site Visits (Pre-Award):

The University, at its sole discretion, may require oral presentations, product demonstrations and/or vendor location site visits to validate information submitted with the bids. Failure of a bidder to conduct a presentation on the date scheduled or allow an on-site/vendor site visit may result in rejection of the bid. These events cannot be used as an opportunity to alter bids submitted.

2.2 Reasonable Accommodations:

The University will provide reasonable accommodations, including the provision of informational material in an alternative format, for qualified individuals with disabilities upon request.

2.3 GSA Pricing:

This bid may qualify for GSA Pricing. If you have a GSA contract covering any of the items specified, enclose information on use of that contract including the contract number.

2.4 Method of Bid:

The Bidder shall submit a list price and a net unit price. Prices shall be in U.S. dollars unless otherwise indicated. In the event of errors in calculation, unit price shall prevail.

2.5 Method of Award:

Award(s) shall be made on the basis of the lowest net line-item price(s) Bids that state the University shall guarantee orders of a specific quantity or dollar amount will be disqualified. The University is the sole determinant of its best interests.

• Supplier Diversity Preferences State of Wisconsin agencies may make awards to certified Minority Business Enterprise (MBE), or Disabled Veteran-Owned Business (DVB) firms submitting the lowest qualified bid when that qualified bid is not more than 5% higher than the apparent low bid or the proposal is no more than 5% lower than the apparent high point score. Authority for this program is found in ss. 16.75(3m) (b)2,3, 16.75(3m) (c)(4) and 560.0335(1)(b)(3), 15.107(2), 16.75(4), 16.75(5) and 560.036(2), Wisconsin Statutes.

• Life Cycle Cost Life Cycle Cost formulas may be used in evaluation for bid awards which may include, but are not limited to: the applicable costs of energy efficiency, acquisition and conversions, interest charged, transportation, warranties, maintenance fees, licenses, disposal, or any other costs not directly related to the bid

3. Bidder Qualifications

3.1 Bidder Experience:

Bidder company or its principals must be in the business of providing the requested items/services and must have done so for the past THREE (3) years.

3.2 Authorization:

Bidder must be an original manufacturer, authorized distributor, or dealer authorized by manufacturer with service and repair capabilities for the item. Provide account number with manufacturer, as applicable, in the TECHNICAL RESPONSE

QUESTIONS.

4. Performance and Contract Requirements

4.1 F.O.B. Destination and Installed:

All deliveries shall be FOB Destination and Installed. Delivery and installation charges and risk of loss shall be borne by the Contractor.

Items are to be installed at MRI Laboratory room 1330 Wisconsin Institutes of Medical Research 1111 Highland Avenue Madison, WI 53705 , F.O.B. Destination Installed. Bid prices must include all packing, freight, insurance, set-up, instruction, per diem, and operation manual charges, excluding any import/export costs. Items must be set in place and connected to utilities, as applicable, installed in the area designated by University personnel, demonstrated to be in operating condition, and approved by University personnel. All debris must be removed from the University premises and properly disposed of by the Contractor. Upon installation, all operating instructions and maintenance manuals must be furnished to University personnel. You may be asked to Indicate the Country of Origin and Shipping Point. See University Imports clause if applicable.

Failure to bid FOB Destination Installed delivery and installation charges and risk of loss borne by the Contractor in price may disqualify your bid.

4.2 Special Pandemic and Emergency Operations Considerations:

The University of Wisconsin System, individual campuses, municipalities, counties, or the State or Federal government may have emergency orders or guidelines in place mandating or recommending measures such as face masks, protective gear, hand washing, temperature checks, symptom reporting, social distancing, or other temporary public health and safety measures. All suppliers visiting UW campuses or participating in UW sponsored activities, whether on or off campus, must comply with all relevant University, campus, government, and public health and safety mandates and guidelines unless specifically exempted by the applicable legislation, executive order, or public health order. UW reserves the right to impose additional health and safety requirements, processes, and procedures at any time. Bidders, contractors and suppliers and their support personnel present in person at any UW site or event must comply with all such applicable measures in effect at that location.

4.3 University Imports:

Definitions:

- Custom Charges/Fees: typically includes, but is not limited to, United States duties, if applicable; port of entry documentation fees; custom clearance fees; applicable tax; etc.

- University Imports: When the University is the Importer of Record or has responsibilities for paying Custom

Charges/Fees for products purchased directly from a foreign country.

Bids must include costs from bidder’s door to port of destination and local delivery charges. Custom Charges/Fees should be itemized with bidders submitted pricing. Custom Charges/ Fees will be included in the cost for the purpose of determining the lowest cost bid. The University reserves the right to compare the quoted Custom Charges/Fees with those from a University contracted customs broker and select whichever option is judged to be in the best interest of the University.

If the University is selecting the customs broker and paying the Custom Charges/Fees directly to them, the awarded Contractor must use the University's contracted customs broker identified on the purchase order.

4.4 Mandatory Reporting of Child Abuse or Neglect:

If, in the course of providing services to the UW, Contractor (or its employee) observes an incident or threat of child abuse or neglect, or learns of an incident or threat of child abuse or neglect, and the Contractor (or its employee) has reasonable cause to believe that child abuse or neglect has occurred or will occur, Contractor must make a report of that abuse or neglect to law enforcement or to a county social service agency as provided in UW’s Policy on Mandatory Reporting of Child Abuse and Neglect (“the Policy”). If the suspected child abuse or neglect involves an allegation against a UW employee or agent (e.g., student, volunteer, contractor, etc.), or the incident or threat of child abuse or neglect occurred on a UW campus or during a UW-sponsored event, the Contractor shall also report to the Police Department.

4.5 Timeliness of Delivery:

Delivery is desired within 4 weeks after the purchase order has been issued. If unable to deliver by the stated date, indicate in the TECHNICAL RESPONSE QUESTIONS the earliest delivery date possible. Timeliness of delivery may be used in evaluation for bid award.

Once awarded, failure to meet this delivery date may result in cancellation of order (award). The University reserves the right to contract with a second vendor/contractor to receive the items/services per delivery requests.

The contractor is required to notify the ordering department of any back order, discontinuation of item(s) or other delays in shipping within of receipt of order or release against existing order(s).

4.6 Acceptance and Testing (Post Award):

Acceptance testing will occur once the vendor has demonstrated that the instrument has met acceptable criteria as evaluated by the vendor during the installation. Acceptance testing will be performed with the 5-day on-site training that immediately follows the installation by the vendor with University staff and will consist of verification of the specifications and performance requirements.

If the item/service does not meet specification or performance requirements, the Contractor will have ten working days to meet requirements. If after this time period the item/service still does not meet specifications or performance requirements, the Contractor agrees to remove the item and return any payments that may have been made.

Mark D “Marty” Pagel, or a designee, is the only authorized person who may sign an acceptance form. The warranty period will begin following the successful acceptance testing.

4.7 Payment Terms:

Payment will not be made until the item/service is determined to meet all specifications and has been accepted by the University. The University will pay the Contractor NET 30 DAYS as accepted by the University.

4.8 Shipping, Duplicates, and Over shipments:

Upon notification by the University of a duplicated order or over shipment, the items identified must be removed at the Contractor's expense. If the duplicated or over shipment items are not removed within 30 days of written notification, the University reserves the right to dispose of them as its own property and shall not be held liable for any cost for the items.

4.9 Training:

Contractor must provide personnel with instructions on set-up and operation of the items at no charge to the University.

Training requirements are specified in the bid specifications.

4.10 Insurance:

The Contractor shall maintain insurance levels as required in the DOA 3054 Standard Terms and Conditions – Section

23.0. A certificate of insurance must be provided upon award.

The Contractor shall add: “The Board of Regents of the University of Wisconsin System, its officers, employees and agents” as an ‘additional insured’ under the commercial general, automobile, and Contractor's liability policies. The certificate holder shall be listed as the University of Wisconsin-System Administration or System campus for their respective purchases.

4.11 Subcontracting:

• Any Contract resulting from this bid shall not be, in whole or in part, subcontracted, assigned, or otherwise transferred to any Subcontractor without prior written approval by Purchasing. Upon request Contractor must provide Subcontractor’s complete contact information including EIN# (TIN#, SS#) and signed W-9 form.

• The Contractor shall be directly responsible for any subcontractor's performance and work quality when used by the Contractor to carry out the scope of the job. University reserves the right to assess Contractor damages in excess of the contract amount for Subcontractor’s failure to perform or inability to complete required project milestones.

• Subcontractors must abide by all terms and conditions under this Contract.

• If Subcontractors are to be used, the Contractor must clearly explain their participation, deliverables, and project milestones prior to commencing work.

4.12 Record and Audit:

The Contractor shall establish, maintain, report as needed, and submit upon request records of all transactions conducted under the contract. All records must be kept in accordance with generally accepted accounting procedures.

All procedures must be in accordance with federal, State of Wisconsin, and local ordinances.

The University shall have the right to audit, review, examine, copy, and transcribe any pertinent records or documents held by the Contractor related to this contract. The Contractor shall retain all applicable documents for a period of not less than five years after the final contract payment is made. The University reserves the right to inspect any facilities used to support this Contract.

4.13 Refund of Credits:

The contractor agrees to pay the state within 60 days, at the state's request, any credits resulting from the order which the state determines cannot be applied to future invoices.

4.14 Invoice Dispute:

Pursuant 16.528(3)(e) the UW System will notify supplier by e-mail or mail, at its discretion, of any disputed invoice.

4.15 Entire Contract:

A purchase order will be issued based on the criteria established in this Request for Bid, including attachments and any amendments issued. The RFB, the bid response, and written communications incorporated into the contract constitute the entire contract between the parties. The hierarchy of documents in descending order for resolution is as follows:

A. Official Purchase Order B. This Original Request Bid including amendments/attachments C. Bidder response to RFB

Any other terms and conditions provided by the Bidder with the bid or for future transactions against this procurement, including but not limited to click on agreements accepted by the Department; shrink wrapped agreements; or terms submitted with quotations, order acknowledgements, or invoices; will be considered null and void and will not be enforceable by the Contractor unless agreed to in a written amendment signed by the University Purchasing department. Any exceptions to this RFB should be submitted with your response and alternative language proposed.

Submitting a standard Bidder contract or term and condition as a complete substitute or alternative for the language in this solicitation will not be accepted and may result in rejection of the bid. The University reserves the right to negotiate contractual terms and conditions or reject the Bidder’s response and proceed to the next qualified bidder.

5. Specifications

UW Specifications may not be revised without an official written amendment issued by Purchasing.

5.1 Bid Response:

The Bidder’s response must be clearly identified by manufacturer and catalog/model/stock number and/or appropriate identification as requested. Adequate detailed specifications of the items/services being offered, or bid must be included with your bid to ensure that the items/services being bid can be compared to determine if the items/services meet all specifications.

If you are bidding alternate items/services, provide complete specifications, documents and materials showing performance features and details for the items/services you propose to furnish for each item/service being bid. These will be used to establish equivalency. The University will be the sole judge of equivalent acceptability between Bidders’ responses.

5.2 Warranty:

• Contractor must provide a minimum warranty of FIVE (5) year(s) to include parts, labor and travel purchased under this contract.

• Contractor is requested to provide a copy of maintenance contracts and quote on maintenance available after expiration of the warranty term. Include terms, which components shall be covered and annual cost in your response in the TECHNICAL RESPONSE QUESTION or on attachments to the bid response, as necessary.

• Contractor must use only manufacturer trained personnel for this contract.

5.3 NRTL Certification:

The University strives to make sure all equipment purchased has the appropriate United States (US) NRTL certification (Nationally Recognized Testing Laboratories (NRTLs) | Current List of NRTLs | Occupational Safety and Health Administration (osha.gov)). Bidders should provide a list of all NRTL certifications their proposed product has achieved in their bid/proposal response. The University reserves the right to add the costs associated with acquiring an independent US NRTL certification to the submitted bid price to establish comparable costs across all responses. Preference may be applied to products that will have US NRTL certifications prior to shipment.

5.4 Maintenance and Repair:

• Contractor must perform all maintenance on site unless University grants permission to remove equipment from site.

• Contractors must have access to replacement parts within ten working days to service all machines identified under this bid.

• Service calls received before noon must be acknowledged by end of business of the same day and the machine must be serviced within three working days of initial call. The service representative shall leave the ordering department a copy of a dated, written report indicating the service performed. This report must be signed by the University employee in charge of the machine.

• Contractor must complete all maintenance or repair services within ten working days of the initial call. If Contractor cannot complete all services within this time, the Contractor must provide a progress report of the repair to the department. The service representative shall leave with the ordering department a copy of a dated, written report indicating the service performed. This report must be signed by the University employee in charge of the machine.

• Contractor shall provide unlimited call-back maintenance service during normal business hours, defined as 8:00 A.M.

to 4:00 P.M., Central Standard Time or Central Daylight Time, Monday through Friday, excluding holidays.

https://www.osha.gov/dts/otpca/nrtl/nrtllist.html https://www.osha.gov/dts/otpca/nrtl/nrtllist.html

5.5 Maintenance Inspections:

Contractor must provide a minimum of two maintenance inspection(s) per year. Contractor must coordinate and schedule dates and times with the University contact person.

5.6 Service Hours:

Bid must include labor and travel time during stated service hours. University services hours shall be defined as 8:00 A.M. to 5:00 P.M. Central Standard Time or Central Daylight Time, Monday through Friday, excluding holidays. Bidders must identify if travel time charge per hour is the same as labor time per hour and if all employees will be charged at the same rate.

5.7 Additional Vendors:

Purchasing shall have the option to contract with another vendor to repair or service machines if Contractor is unable to repair equipment for any reason or make necessary repairs on a timely basis.

5.8 Emergency Situations:

In the event of an emergency situation (pandemic, snowstorm, etc.), Contractor must be prepared to supply the University with the items/services on this bid as required. An emergency preparedness plan to serve the University, and the items/services that are available to meet emergency needs, must be provided if requested by the University.

Minimally, this plan should include emergency contract information, product and service level availability, staffing, equipment, and logistics plan.

5.9 Trade-In:

Information will be found on the Cost Proposal Sheet in the Buyer Attachments. Arrangements should be made to inspect the equipment with the ordering department. If trade-in option is awarded, Contractor will remove trade-in equipment at the time of installation of new equipment at no extra charge to the University.

5.10 Employee Identification:

All the Contractor’s employees, while working on University property, must wear a clearly displayed photo identification badge or uniform showing name of employee and/or company represented. Any identification must be provided by the Contractor at the Contractor’s cost. NOTE: Badges must be available but will not be required to be worn when protective clothing and respiratory protection is required.

5.11 Cables:

Any alternate product bid must be compatible with and capable of being interfaced with identical cables and connectors used with the specified equipment with no additional expense to the University to make the alternate product compatible with existing equipment.

5.12 On-Site Demonstration:

An on-site demonstration of any product may be required for evaluation purposes. This demonstration is to be without expense or obligation to the University. The University will not be liable for any loss or damage. If requested, the demonstration must occur as negotiated with the Contractor.

5.13 Environmentally Friendly (“Green”) Product:

Contractors are encouraged to identify products that are made of recycled products, that use environmentally friendly production methods, or that can be recycled at the end of their service life. The UW will make every effort to purchase “Green” products wherever feasible or possible based on individual project needs and funding available.

6. TECHNICAL SPECIFICATIONS

Scope: Purchase of a Small Animal 7T MRI Instrument The instrument will be used for anatomical imaging, functional imaging, and molecular imaging studies of small animal models including (but not limited to) mice, rats, and marmosets.

These imaging results will support research that investigates a variety of biological conditions and pathological diseases, including cancer, cardiovascular disease, neurological conditions, musculoskeletal diseases, metabolic diseases, and infectious diseases. The instrument will also be used for theragnostic research that combines diagnoses and therapy for cancer and other pathologies.

Conditions of bid which include the word “must” or “shall” describe a mandatory requirement. All specifications are defined as mandatory minimum requirements unless otherwise stated. FAILURE TO MEET A MANDATORY REQUIREMENT SHALL DISQUALIFY YOUR BID. If no bidder is able to comply with a given specification, condition of bid or provide a specific item/service requested, Purchasing reserves the right to delete that specification, condition of bid or item without having to complete the bid process again.

MEET

SPECIFICATIONS

ITEM DESCRIPTION YES NO

1. 7-Tesla Superconducting MRI instrument 1A 100% cryogen-free, self-shielded, small-footprint 7T MRI magnet.

The magnet must be capable of being placed in an idle mode when not used. The magnet must be capable of being energized locally or remotely after a quench. The system must be 100% free of liquid helium. The system weight must be less than 1000 Kg and the height must be less than 250 cm.

1B Cryocooler unit.

The cryo-cooler unit must be posterior to the magnet for easy access, rather than a cryo-cooler unit that is below the magnet that is more difficult to access. The cryo-cooler unit must be completely isolated from the magnet so that vibrations are not transmitted into the magnet and the MRI detector system.

OMIT OMIT

1C MRI radiofrequency console with capabilities for 1 transmit channel and 4 receive channels.

1D Actively shielded gradient system at a minimum of 650 mT/m gradient strength The gradient system must include digital eddy current compensation with cross-term pre-emphasis.

1E Shim system with higher order shims.

1F Cooling system for superconducting magnet and gradient coils.

1G LCD monitor integrated in the magnet system for displaying physiological monitoring information in real time, and for displaying the operation of the MRI system in real time, including but not limited to calibrations and acquisitions.

1H The ability to upgrade the number of receiver channels to 128 channels in the future, in an efficient and cost-effective way.

1I Representative images of 1 mouse body, 1 mouse brain, 1 rat body, 1 rat brain, 1 marmoset body, 1 marmoset brain, and 3 mouse bodies that are simultaneously imaged must be provided to demonstrate that the MRI instrument is capable of imaging these animals.

2. Transmitter and receiver coils for imaging mice, rats, and marmosets:

2A Mouse whole-body RF coil (inner diameter 35-42 mm) 2B Rat/marmoset whole-body RF coil (inner diameter 72-86 mm) 2C Receive-only surface coil (inner diameter 18-21 mm) 2D Mouse brain volume coil (inner diameter 12-30 mm) 2E Rat/marmoset brain volume coil (inner diameter 40-45 mm)

3. Workstations 3A A workstation with 24" LCD Display with software for acquisition and processing.

3B A second workstation for additional post-processing, with a 24" LCD Display and software for processing including licenses, and a DICOM Server with license.

4. Software 4A Software for operating the MRI instrument including automated spectrometer frequency centering, automated shimming, automated pulse power calibration, automated receiver gain optimization, quantitative B1 mapping, and B0 mapping. The software must also include processing and analysis tools relaxation curve fitting, diffusion curve fitting, and signal amplitude analysis.

4B Software for pulse sequence development for programming of new acquisition methods, including the capability to convert scripts for Python and Matlab into new acquisition programs.

4C MR spectroscopy Acquisition methods: PRESS, STEAM, LASER, semi-LASER, EPSI, CSI.

4D T1, T2, and T2* relaxation-based MRI Acquisition methods: Multi-Echo Gradient Echo, Multi Inversion Recovery SE and FSE, Multi Echo Spin Echo, Multi FlipAngle GRE 3D, T1 Echo Planar Imaging.

4E Diffusion-based MRI Acquisition methods: Spin Echo Diffusion Tensor Imaging, Echo Planar Imaging for Diffusion Tensor Imaging, Spiral Diffusion Tensor Imaging, Echo Planar Imaging for Diffusion Weighted Imaging.

4F Fat/water imaging Acquisition methods: 2-point DIXON, 3-point DIXON, Fat chemical shift corrected images.

4G Arterial Spin Labeling Acquisition methods: Spin Echo EPI, Gradient Echo EPI, FAIR Fast Spin Echo, FAIR EPI.

4H Cardiac MRI Acquisition methods: Flow Compensated Gradient Echo, CINE cardiac Black/Bright blood imaging, Multi-slice Double-Inversion Recovery module for Fast Spin Echo sequence, ECG gating options for each method.

4H MR Angiography Acquisition methods: 2D Time-of-Flight MR Angiography, 3D Time-of- Flight MR Angiography, Phase Contrast MR Angiography.

4I Dynamic Contrast Enhanced (DCE) MRI Acquisition methods: DCE Gradient Echo with keyhole option.

4J Automated dynamic shimming.

4K Automated image separation software that separates the images of each animal when imaging more than one animal in a single image.

4L Image conversion to DICOM format, a standard format for medical imaging, for individual animals and for the automated image separation software.

4M Image format compatibility with VivoQuant.

5. Animal handling and monitoring system 5A Animal temperature control system for one mouse, rat, and marmoset. The control system must use air to warm the animal.

5B Respiratory & cardiac monitoring and gating system for one mouse, rat, and marmoset.

5C One cradle for a single mouse.

5D One cradle for a single rat.

5E One cradle for a single rat that fits within a rat brain coil.

5F One cradle for a single marmoset.

5G One cradle for 3 mice with monitoring of respiration and temperature.

6 Set of phantoms (chemical samples) for Quality Control.

7 Shipping with delivery time within 4 weeks of issuing the Purchase Order.

8 Pre-installation visit for site planning.

9 Installation of the instrument that will meet manufacturer’s specifications.

10 5 days of on-site application training (initial training) that do not expire

11 5 days of on-site Advanced training (follow-up training) that do not expire

12 Training for advanced programming of acquisition methods

13. 5-year warranty 13A Two preventive maintenance (PM) visits per year with full instrument recalibration

13B Unlimited remote support 13C Costs of labor, travel, and accommodation for repair of system failures

13D Costs of all spare parts including magnet cold head

13E Software upgrades for software versions that do not require a hardware upgrade

Optional Future Purchase – PET insert for the Small Animal 7T MRI Instrument Positron Emission Tomography (PET) detection system that is compatible with the MRI instrument, for performing simultaneous PET/MRI studies with small animal models. This PET system includes the PET detector that is inserted and automatically integrated into the magnet, electronics components connected to the PET detector that reside outside the magnet, as well as a separate workstation if the PET system requires a workstation that is separate from the MRI workstation. The PET detector crystals must be pixelated LSO crystals that are 1.0-1.2 mm on one side, 1.0-1.2 mm on a second side, and at least 10 mm on a third side. The PET system must have triple coincidence detection, have positron range correction, and must not require water cooling. Performance specifications for the PET system include 0.7 mm isotropic spatial resolution, 4.5 cm transaxial field of view, and a Noise Equivalent Count (NEC) rate of 14 kcps/MBq or higher. The PET images and MR images should show no degradation in sensitivity and image artifacts when performing simultaneous PET/MRI.

• Optional Future Purchase – Pet insert for Small Animal 7T MRI Instrument needs to be amended to read as follows:

Positron Emission Tomography (PET) detection system that is compatible with the MRI instrument, for performing simultaneous PET/MRI studies with small animal models. This PET system includes the PET detector that is inserted and automatically integrated into the magnet, electronics components connected to the PET detector that reside outside the magnet, as well as a separate workstation if the PET system requires a workstation that is separate from the MRI workstation. The PET system must not require water cooling. A PET insert with triple coincidence detection, have positron range correction is preferred but not required. Performance specifications for the PET system include 0.7 mm isotropic spatial resolution, 4.5 cm transaxial field of view, and a Noise Equivalent Count (NEC) rate of 5 kcps/MBq or higher. The PET images and MR images should show no degradation in sensitivity and image artifacts when performing simultaneous

PET/MRI.

6. TECHNICAL SPECIFICATIONS