B08_140G0218R0044_Attch_1_PWS_Tables_1_&_2.xlsx

XLSX spreadsheet 14 KB Posted Aug 21, 2018

Attached to: WATER SAMPLE ANALYSIS SERVICES, Multi-endpoint Gene Regulatory Assays
Solicitation number: 140G0218R0044
Issued by: Department of the Interior US Geological Survey

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140G0218R0044 Attachment 1 PWS Tables 1 & 2

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File	Type	Posted
Sol_140G0218R0044.pdf	PDF	Aug 21, 2018
Sol_140G0218R0044.pdf	PDF	Aug 3, 2018
B08_140G0218R0044_Attch_1_PWS_Tables_1_&_2.xlsx	XLSX spreadsheet	Aug 3, 2018

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Table_1

Table 1	46 transcription factor pathways to be assessed
#	Endpoint Name	Transcription Factor / Pathway
1	TGFb	SMAD Family / TGFb Pathway
2	HNF6	The transcription factor hepatocyte nuclear factor 6
3	TCF/b-cat	TCF-1 Family/ Wnt Pathway
4	E-box	c-Myc, Upstream stimulatory factor 1 (USF-1)
5	PPRE	Peroxisome proliferator activating receptor (PPAR)a, d, g
6	NFI	The nuclear factor 1 (NF1) family proteins
7	PXR	The pregnane X receptor (PXR), Xenobiotic Pathway
8	GRE	The glucocorticoid receptor (GR)
9	AP-1	The activator protein 1 (AP-1: c-fos/c-jun)
10	ISRE	Interferone regulatory factors IRF1, IFR3 / Interferone Pathway
11	MRE	The metal regulatory transcription factor 1 (MTF-1)
12	STAT3	Signal transducer and activator of transcription 3(STAT3) / IL-6 Pathway
13	NF-kB	The nuclear factor kappa B family / TNFa, IL-1b Pathways
14	FoxA	The forkhead box protein A
15	CMV	Cytomegalovirus promoter-enhancer
16	Xbp1	X-Box protein 1, Protein misfolding, EPR stress Pathway
17	CRE	cAMP-responsive DNA-binding protein (CREB) Family / cAMP Pathway
18	AhR	The Aryl hydrocarbon receptor (AhR) / Xenobiotic Response
19	EGR	Early growth response protein 1 (EGR1)
20	ARE	Antioxidant Response Element (ARE)-binding Nuclear factor (erythroid-derived 2)-like 2 (NRF2)
21	ERE	Estrogen Receptor (ER) pathway
22	Oct	The POU domain Family, octamer transcription factor family
23	LXR (DR4)	The liver X receptor family (Direct repeat 4-binding proteins)
24	HSE	The heat shock factor -1 (HSF-1) / heat shock pathway
25	SREBP	Sterol Regulatory Element-Binding Proteins (SREBPs)
26	p53	The p53 transcription factor / DNA damage Response
27	BRE	SMAD Family / Bone morphogenetic protein pathway
28	Pax	The transcription factor paired box (PAX)
29	HIF1a	The hypoxia-inducible factor-1a (HIF1a) / hypoxia pathway
30	VDRE	The vitamin D receptor (VDR) / vitamin D pathway
31	RORE	Retinoic acid receptor -related orphan receptor proteins (ROR) a,b,g
32	Ets	The ETS (E-twenty six) transcription factor family
33	GLI-1	The Gli-1 transcription factor/ Hedgehog (Hh) signaling pathway
34	NRF1	The nuclear respiratory factor 1
35	GATA	The GATA-binding factor family
36	E2F	The E2F transcription factor family
37	C/EBP	The CCAAT-enhancer-binding proteins transcription factor family
38	Myb	The MYB (myeloblastosis) family of transcription factors
39	PBREM	The phenobarbital responsive enhancer module /constitutive androstane receptor (CAR) pathway
40	FXRE (IR1)	The farnesoid X receptor (FXR), an inverted repeat-1 (IR1) binding protein
41	AP-2	The activating protein 2 (AP-2) family of transcription factors
42	RARE(DR5)	The retinoic acid receptors (RARa),b,g
43	FoxO	Forkhead box proteins FOXO1 and FOXO3
44	SOX	The SOX transcription factor family
45	Sp1	Ubiquitous Sp1 family of transcription factors
46	Myc	The c-Myc transcription factor

Table_2

Table 2	48 human nuclear receptors to be assessed.
#	Abbreviation	Name	Nomenclature
1	AR	Androgen receptor	NR3C4
2	CAR	Constitutive androstane receptor	NR1I3
3	ERa	Estrogen receptor-a	NR3A1
4	ERRa	Estrogen-related receptor-a	NR3B1
5	ERRg	Estrogen-related receptor-g	NR3B3
6	FXR	Farnesoid X receptor	NR1H4
7	GR	Glucocorticoid receptor	NR3C1
8	HNF4a	Hepatocyte nuclear factor-4-a	NR2A1
9	LXRa	Liver X receptor-a	NR1H3
10	LXRb	Liver X receptor-b	NR1H2
11	NURR1	Nuclear receptor related 1	NR4A2
12	PPARa	Peroxisome proliferator-activated receptor-a	NR1C1
13	PPARd	Peroxisome proliferator-activated receptor-d	NR1C3
14	PPARg	Peroxisome proliferator-activated receptor-g	NR1C2
15	PXR	Pregnane X receptor	NR1I2
16	RARa	Retinoic acid receptor-a	NR1B1
17	RARb	Retinoic acid receptor-b	NR1B2
18	RARg	Retinoic acid receptor-g	NR1B3
19	RORb	RAR-related orphan receptor-b	NR1F1
20	RORg	RAR-related orphan receptor-g	NR1F3
21	RXRa	Retinoid X receptor-a	NR2B1
22	RXRb	Retinoid X receptor-b	NR2B2
23	TRa	Thyroid hormone receptor-a	NR1A1
24	VDR	Vitamin D receptor	NR1I1
25	COUP-TF1	COUP transcription factor 1	NR2F1
26	COUP-TF2	COUP transcription factor 2	NR2F2
27	DAX1	DSS-AHC critical region on the X chromosome protein 1	NR0B1
28	EAR2	V-erbA-related protein 2	NR2F6
29	ERb	estrogen nuclear receptor beta	NR3A2
30	ERRb	estrogen-related receptor beta	NR3B2
31	GCNF	germ cell nuclear factor variant 1	NR6A1
32	HNF4g	hepatocyte nuclear factor 4-gamma	NR2A2
33	LRH1	liver receptor homolog 1	NR5A2
34	MR	mineralocorticoid receptor	NR3C2
35	NOR1	neuron-derived orphan receptor 1	NR4A3
36	NURR77	hormone receptor NUR/77	NR4A1
37	PNR	photoreceptor-specific nuclear receptor	NR2E3
38	PR	progesterone receptor	NR3C3
39	Rev-ERB-a	V-erbA-related protein alpha	NR1D1
40	Rev-ERB-b	V-erbA-related protein beta	NR1D2
41	RORa	retinoid-related orphan receptor-alpha	NR1F1
42	RXRg	retinoid X receptor gamma	NR2B3
43	SF-1	steroidogenic factor 1	NR5A1
44	SHP	small heterodimer partner	NR0B2
45	TLX	tailless homolog X	NR2E1
46	THRb	thyroid hormone nuclear receptor beta	NR1A2
47	TR2	testicular receptor 2	NR2C1
48	TR4	testicular receptor 4	NR2C2

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