Amendment 0001.docx
DOCX document 15 KB Posted
- Attached to
- CMOS Microelectrode Array System Federal contract opportunity
- Solicitation number
- 1333ND26QNB680354
About this file
This file is an amendment to a federal solicitation that provides clarifications to vendor questions regarding a CMOS Microelectrode Array (HD-MEA) system procurement by the National Institute of Standards and Technology (NIST), a division of the Department of Commerce. The amendment extends the solicitation response deadline and addresses six technical inquiries submitted by prospective vendors.
The key technical specifications clarified in the amendment include: the recording subjects are in vitro neurons, neuronal organoids, and micro physiological systems utilizing various cell types such as neurons or cardiomyocytes; the system must support a minimum of 1,000 simultaneous voltage recording channels per well; cells will be cultured directly on the HD-MEA surface with a culture well to contain media; the system must include hardware for synchronizing and triggering recordings to external equipment and a software API for active experimental control, including closed-loop feedback and automation capabilities; and video tracking camera setup is not required as NIST possesses existing compatible microscopy imaging systems. The amendment confirms that a motorized commutator and head-fixed animal recording configurations are not needed, as the application involves fixed cell cultures rather than in vivo or freely-moving subjects. The solicitation number is 1333ND26QNB680354, and this amendment represents the first modification to the original solicitation document.
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| File | Type | Posted |
|---|---|---|
| 1333ND26QNB680354.pdf |
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Text version
Amendment 0001:
The purpose of this amendment is to answer questions submitted by vendors and extend the solicitation response date.
Question 1: What is your recording subject?
NIST Answer: As listed in Statement of Work (SOW), the measurement subjects are in vitro neurons, neuronal organoids, and micro physiological systems with various cell types such as neurons or cardiomyocytes.
Question 2: How many recording channels channel are you looking for? This will determine the channel capacity needed and head stages to be used.
NIST Answer: As specified in the SOW, ≥ 1000 simultaneous Voltage recording channels per well at minimum.
Question 3: What is your implant type and connector?
NIST Answer: As specified, the in vitro cells will be cultured directly on top of the HD-MEA surface and a culture well to contain the media is required.
Question 4: Is the subject going to be head-fixed. anesthetized, or freely moving during the recording.
NIST Answer: No, the cells will be cultured directly on top of the HD-MEA surface.
Question 5: For freely-moving wired subjects, we also offer a motorized commutator called the Saturn. Are you interested in commutator?
NIST Answer: No, the cell location will be fixed directly on top of the HD-MEA surface.
Question 6: Do you require external device synchronization or planning to deliver a stimulus?
NIST Answer: Yes, both are required. From the specification in SOW: Hardware is required for synchronizing and/or triggering recordings to external equipment, and a software API is required for active control over experiments, including closed-loop feedback experiments and automation of functions using sequencing and/or triggering.
Question 6: Do you need video tracking camera setup?
NIST Answer: No, NIST has existing microscopy imaging systems that would be suitable for the specified HD-MEA system.
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