1_ Statement of Work.pdf

This solicitation requests proposals to develop humanized mouse models for the enzymes NNMT and SULT1A1. Specifically, the National Institute on Drug Abuse within the Department of Health and Human Services seeks to award a contract to create mouse models that express human versions of nicotinamide N-methyltransferase and sulfotransferase family 1A phenol-preferring member 1 in order to study drug metabolism and toxicity pathways involving these enzymes. Proposals are due by December 15, 2022, and the period of performance for the awarded contract is expected to be three years beginning around April 2023. The contractor will be expected to generate and characterize transgenic mouse lines and make them available to the research community for further study.