CRO Support for NCATS Medicinal Chemistry for Lead Optimization
Ended Master IDIQ Awarded
- Federal agency
-
National Center for Advancing Translational Sciences
- Awardees
- 9
- Task orders
- 12
- Obligated
- $6,506,033
Vehicle facts
- Opportunity
-
- N01TR192007 Solicitation number
- Agency
-
- National Center for Advancing Translational Sciences National Institutes of Health, Department of Health and Human Services
- Combined task order value
-
- $6,506,033 Current, with exercised options
- $9,751,314 Potential, with all options
- Last date to order 100% complete
- Shared ceiling 36% used
- $17,887,012.00
IDV award and task order details come from SAM.gov/FPDS.
About this vehicle
The National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health awarded this Master IDIQ on September 26, 2019, to support preclinical drug development through contracted research organization services in medicinal chemistry for lead optimization, but the ordering period closed on September 25, 2024, and no new task orders may be placed against the vehicle.
The vehicle is functionally inactive. The most recent task order was awarded on September 28, 2022, more than three years ago. Ordering velocity fell sharply after initial launch: nine task orders were awarded in 2019 at vehicle kickoff, with one each in 2020, 2021, and 2022. The vehicle's combined potential value stands at $9.9 million, with $6.6 million (67 percent) obligated.
Task orders procure synthetic chemistry support and lead optimization services for drug candidates. Representative work includes synthetic chemistry support for the translational drug branch medicinal chemistry team and lead optimization of dopamine D3 receptor antagonist for substance use disorder. Pricing is predominantly cost no fee or time and materials; one task order used firm fixed price for contract kickoff conferences.
The prime contractor base is highly concentrated. Regents of the University of Minnesota holds three orders valued at $6.2 million combined potential (62 percent of vehicle value), while Organix Chemistry Solutions LLC holds two orders valued at $3.7 million (37 percent). The remaining seven primes — Alchem Laboratories Corporation, Research Triangle Institute, Eurofins Discovery Services North America LLC, and four others — collectively hold one thousand dollars in potential value. Eleven of twelve task orders fund NCATS directly, with the National Institute on Drug Abuse placing one order valued at $1.7 million. All task orders were awarded unrestricted (no set-aside designations applied).
Description
The Division of Preclinical Innovation (DPI) at the National Center for Advancing Translational Sciences (NCATS) conducts translational research in the area of human therapeutics development. The objective of this Master IDIQ is to support the DPI drug development programs by identifying preclinical drug candidates with improved efficacy, optimized ADME properties, and minimal predicted toxicity.
IDV awards
Latest task orders
Show all 12
Top awardees by obligations
| Rank | Awardee | Obligated | Share |
|---|---|---|---|
| 1 | Regents Of The University Of Minnesota | $4,673,542 | 72% |
| 2 | Organix Chemistry Solutions LLC | $1,825,492 | 28% |
| 3 | Alchem Laboratories Corporation | $1,000 | <1% |
| 4 | Research Triangle Institute | $1,000 | <1% |
| 5 | Eurofins Discovery Services North America, LLC | $1,000 | <1% |
| 6 | Southern Research Institute | $1,000 | <1% |
| 7 | Southwest Research Institute | $1,000 | <1% |
| 8 | Lovelace Biomedical Research Institute | $1,000 | <1% |
| 9 | Sri International | $1,000 | <1% |
Top funding agencies by obligations
| Rank | Funding agency | Obligated | Share |
|---|---|---|---|
| 1 | Department of Health and Human Services | $6,506,033 | 100% |
Obligations by fiscal year
| Fiscal year | Obligated |
|---|---|
| FY2026 | -$138,776 |
| FY2024 | -$41,669 |
| FY2023 | $891,033 |
| FY2022 | $795,308 |
| FY2021 | $2,396,595 |
| FY2020 | $1,718,365 |
| FY2019 | $885,177 |
Quick answers
What is the CRO Support for NCATS Medicinal Chemistry for Lead Optimization contract vehicle?
CRO Support for NCATS Medicinal Chemistry for Lead Optimization is an indefinite delivery, indefinite quantity (IDIQ) contract vehicle run by National Center for Advancing Translational Sciences (National Institutes of Health), awarded on September 26, 2019.
Which companies hold CRO Support for NCATS Medicinal Chemistry for Lead Optimization?
9 companies hold CRO Support for NCATS Medicinal Chemistry for Lead Optimization's IDV awards, one each. The latest went to Eurofins Discovery Services North America, LLC on September 26, 2019. The awardees whose task orders obligated the most are Regents Of The University Of Minnesota, Organix Chemistry Solutions LLC and Alchem Laboratories Corporation.
How much has been spent through CRO Support for NCATS Medicinal Chemistry for Lead Optimization?
12 task orders have been placed under CRO Support for NCATS Medicinal Chemistry for Lead Optimization, obligating $6,506,033.
What is the shared ceiling of CRO Support for NCATS Medicinal Chemistry for Lead Optimization?
CRO Support for NCATS Medicinal Chemistry for Lead Optimization's shared ceiling is $17,887,012; its task orders have used 36% of it.
Which agencies use CRO Support for NCATS Medicinal Chemistry for Lead Optimization the most?
The departments whose task orders under CRO Support for NCATS Medicinal Chemistry for Lead Optimization obligated the most are Department of Health and Human Services ($6,506,033).
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