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Indefinite Delivery Contract HHSO100201500005I
Award Date
9/30/15
Last Date to Order
9/30/21
Overview
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Activity
2
Contract IDVs
Contract Awards
2
Transactions
7
Price Lists
Opportunity Stack
1
Federal Agency
Office of the Assistant Secretary for Preparedness and Response
Awardee
Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek TNO
Ultimate Awardee
Not listed
NAICS Category
541711 - Research and Development in Biotechnology
PSC Category
AN13 - Health R&D Services; Health Care Services; Experimental Development
Federal Contract Vehicle
BARDA Chem and RadNuc Animal Model 2015-2020
Pricing Type
Cost Plus Fixed Fee
Legislative Mandate
Clinger Cohen Act
National Interest Action
None
Award Type
Multiple
Primary Consortia Member
Not listed
BARDA Chem and RadNuc Animal Model 2015-2020
Master IDIQ
HHSO100201500005I
Indefinite Delivery Contract
2
Federal Contract Awards
Description
Update #1
TNO DEFENCE, SAFETY & SECURITY (CHEM) - IDIQ FOR BARDA CRN ANIMAL MODEL DEVELOPMENT
Posted 9/30/15, 12:00 AM
Mod #
Description
Reason For Modification
Federal Obligation
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Date
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P00006
TNO DEFENCE, SAFETY & SECURITY (CHEM) - IDIQ FOR BARDA CRN ANIMAL MODEL DEVELOPMENT
Other Administrative Action
$0
9/11/20
P00005
OPTION YEAR 4
Exercise an Option
$0
9/5/19
4
Exercise an Option
$0
9/25/18
3
THE PURPOSE: (1) EXERCISE OPTION #2, CLIN 0003 WHICH EXTENDS THE PERIOD OF PERFORMANCE OF THIS IDIQ CONTRACT FROM SEPTEMBER 30, 2017 TO SEPTEMBER 29, 2018. IN ACCORDANCE WITH FAR 52.217-9 THE GOVERNMENT HEREBY EXERCISES OPTION 2 (CLIN 0003), OPTION YEAR 2 (12 MONTHS) CHEMICAL ANIMAL MODEL DEVELOPMENT & TECHNICAL REPORTS. THIS OPTION HAS A MAXIMUM ORDERING AMOUNT OF $20,000,000 AND A PERIOD OF PERFORMANCE OF SEPTEMBER 30, 2017 TO SEPTEMBER 29, 2018. CONTRACT EXPIRATION DATE: SEPTEMBER 29, 2018 (CHANGED)
Exercise an Option
$0
8/28/17
2
THE PURPOSE: (1) THIS MODIFICATION UPDATES THE CO AND COR, (2) CHANGES THE INVOICE SUBMISSION PROCESS, AND (3) UPDATES THE HHSAR CLAUSE 352.231-70 SALARY RATE LIMITATION. CONTRACT EXPIRATION DATE: SEPTEMBER 29, 2017 (UNCHANGED)
Other Administrative Action
$0
3/2/17
Name
Description
Awardee
Potential Value
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Award Date
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Completion Date
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Updated At
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Delivery Order HHSO100201500005I-HHSO10033001T
This is a task order awarded by the Department of Health and Human Services' Office of the Assistant Secretary for Preparedness and Response (ASPR) to Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek TNO (TNO), a Netherlands-based not-for-profit research organization. The task order, valued at $640,179.91, is to evaluate the efficacy of intranasal scopolamine for increased survival of guinea pigs exposed to sarin, following standard of care treatment. The task order was issued under the Biomedical Advanced Research and Development Authority (BARDA) Chem and RadNuc Animal Model 2015-2020 Indefinite Delivery Contract, which supports BARDA's mission to enable development of medical countermeasures for chemical, biological, radiological and nuclear threats. This task order does not have a set-aside designation.
Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek TNO
$640.2k
9/8/17
3/31/20
12/26/19
Delivery Order HHSO100201500005I-75A50121F33002
This is a cost-plus-fixed-fee delivery order contract awarded by the Office of the Assistant Secretary for Preparedness and Response (ASPR), which is part of the U.S. Department of Health and Human Services (HHS), to the Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek TNO (TNO), a Netherlands-based not-for-profit research organization. The contract, valued at $2,770,928.00, is for the development of a rodent model of synthetic opioid-induced respiratory depression. This work is being conducted under the Biomedical Advanced Research and Development Authority (BARDA) Chem and RadNuc Animal Model 2015-2020 contract, which provides a vehicle for TNO to support BARDA's mission of enabling the development of medical countermeasures for chemical, biological, radiological, and nuclear threats. The contract does not have a set-aside designation and is scheduled for completion by November 10, 2025.
Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek TNO
$2.8m
2/18/21
11/10/25
1/2/25
Name
Description
Solicitation Number
Federal Agency
Type
Posted Date
(Click to sort descending)
BARDA Chem and RadNuc Animal Model Development
Added: Dec 05, 2014 11:42 am The development of animal models is a key element in the successful development of medical countermeasures (MCMs) for chemical, radiological, and nuclear (CRN) threats, particularly since efficacy of products directed against most of these threats cannot be verified using clinical studies. In 2002, the FDA amended its regulations for drugs and biologics to permit approval or licensure of MCMs based on substantial evidence of effectiveness in animals when adequate and well-controlled efficacy studies in humans cannot be conducted because it would be unethical to expose healthy human volunteers to lethal or disabling toxic CBRN substances. This change in the regulations (21 CFR 314.600 for drugs and 21 CFR 601.90 for biologics), commonly referred to as the "Animal Rule," made the design and conduct of adequate efficacy studies in appropriate animal models of paramount regulatory importance, since the inference of efficacy in humans necessary for drug approval or licensure is based solely on efficacy data derived in animals. Demonstration of the safety of the medical countermeasure (drug or biologic) is done in normal, healthy adult humans and in some cases safety in a related pathology particularly if the drug or biologic is already approved for the related pathology.The United States Government (USG) seeks appropriate Good Laboratory Practice (GLP) laboratories that are adequate and available to establish new or existing animal tests and/or models for the development of CRN MCMs. In these models, the challenge dose generally should be the same as that which produces the human disease or condition and the pathophysiological mechanism of its toxicity should be reasonably well-understood and mimic the human disease/condition as closely as possible. When these models are used to test the efficacy of potential MCMs for CRN agents, the mechanism of action of the countermeasure will need to establish the utility of the animal model as a surrogate for humans. BARDA anticipates that contracts awarded from this RFP will serve to facilitate the animal model development of medical countermeasures and/or supportive reagents and assays for regulatory acceptance in the U.S.HHS, through ASPR and BARDA, anticipates multiple awards of Indefinite Delivery Indefinite Quantity (IDIQ) contracts. The anticipated period of performance for any resultant contracts will be for a total of up to 60 months. Additional details and requirements will be described in the solicitation. Offeror's will be required to respond to Sample Request for Task Order Response (RTOR) documents as part of their proposal.Mandatory Criteria for EligibilityOfferors must meet the following mandatory criterion for eligibility for an award: 1. Federal, State, and/or local licenses as required for the operation and control of a clinical level irradiation facility with qualified personnel for the operation, assigned safety restrictions, domestic and instrument calibration per licensed Health Physics authority. (Applies to RadNuc Only)2. Federal, State, and/or local licenses as required for the storage, use, and disposal of select agents such as chemical agents and radionuclides and training of all associated staff responsible for the use of such material. (Applies to both Chem and RadNuc)3. Association for the Assessment and Accreditation of Laboratory Animal Care International (AAALAC) accreditation or equivalent. (Applies to both Chem and RadNuc)4. U.S. Department of Agriculture (USDA) - licensed animal research facility, or equivalent. (Applies to both Chem and RadNuc)5. GLP Capabilities - List of all GLP studies conducted in the past three years. (Applies to both Chem and RadNuc)6. BARDA does not intend to award any contracts to offerors that do not have laboratory space within their facilities to conduct small and/or large animal model studies. Subcontracting is an available option, but only to expand capabilities. (Applies to both Chem and RadNuc)Pre-solicitation Notice ObjectiveThis Pre-solicitation Notice is issued pursuant to FAR Subpart 5.2. It does not constitute a Request for Proposal (RFP) or a promise to issue an RFP in the future. This Pre-solicitation Notice does not commit the Government to contract for any supply or service whatsoever. Further, AMCG is not at this time seeking proposals, and will not accept unsolicited proposals.It is anticipated that an RFP will be available electronically through the FedBizOpps website on or about January 20, 2015, with proposals being due on or about March 4, 2015. Any responsible offeror may submit a proposal that will be considered by the Government. It is the offeror's responsibility to monitor this internet site (www.fbo.gov) for the release of this solicitation as well as any amendments. Potential offerors will be responsible for downloading their own copy of the solicitation and any amendments via this website. No collect calls will be accepted. No facsimile transmissions will be accepted. All responses should be identified with the RFP number, name of firm, size standard of the firm, name of requestor, mailing address, telephone number, fax number, and email address, and should be submitted to the Point of Contact(s) identified in this notice.Multiple awards may result from this solicitation with an estimated award date in July 2015.Furthermore, all respondents must be registered in the System for Award Management (SAM) https://www.sam.gov and have their records updated in the Central Contractor Registry (CCR).
RFP-15-100-SOL-00004
Department of Health and Human Services Immediate Office of the Secretary
Award Notice 1/1
12/5/14, 11:42 AM