Project Grant W911NF261A112

This $2,696,128 federal Project Grant award, funded under the Department of Defense's Military Medical Research and Development program (CFDA 12.420), supports preclinical development of a gene replacement therapy using novel adeno-associated virus (AAV) vectors to treat familial cerebral cavernous malformations (CCM). The prime awardee is Duke University, which is collaborating with the University of Chicago as a sub-awardee. Duke's work focuses on developing the gene therapy treatment, while...

Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Virginia $817,755 on May 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support research into the molecular mechanisms underlying inherited and sporadic brain arteriovenous malformations (BAVMs). The research will be conducted in Charlottesville, Virginia, through February 28, 2030. This project addresses a critical clinical need, as BAVMs represent...

Grant Award Summary The Regenerative Research Foundation received a $428,175 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the period February 15, 2026 through February 14, 2028. The grant supports the development and advancement of a human induced pluripotent stem cell (iPSC)-derived three-dimensional microphysiological model designed to investigate the mechanisms underlying cerebral amyloid angiopathy (CAA) and Alzheimer's disease-related...

Dr. Mark Etherton of Massachusetts General Hospital will receive $338,509.06 from the National Institute of Neurological Disorders and Stroke to study microvascular dysfunction in cerebral small vessel disease and stroke outcomes over four years from July 2021 through April 2026. This Project Grant will support research to elucidate the relationship between white matter microvascular function, ischemic tissue outcomes, and chronic microvascular dysfunction's contribution to structural injury and...

Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a Project Grant award of $743,776 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective September 11, 2025, through August 31, 2033. The award supports research investigating the mechanisms of focal epileptogenesis in mtoropathies—developmental diseases caused by mutations in...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support research on a novel signaling axis involving the protein connexin 43 (CX43) and its role in regulating cancer stem cells in glioblastoma, the most common and deadly form of brain cancer. The $161,000 award to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve...

This $403,750 Project Grant from the National Eye Institute of the Department of Health and Human Services will fund research into the regulation of retinal microvascular stiffness by the matricellular protein CCN1 and its implications for ischemic retinopathy. The awardee, the Research Foundation for the State University of New York on behalf of SUNY Downstate Health Sciences University, will investigate the effects of CCN1 on the mechanical properties of retinal microvascular endothelial cells...

The National Institute of Mental Health (NIMH) has awarded a $1,388,925 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Regents of the University of California, San Francisco (UCSF) to conduct research on the role of vascular mural cells in the development of the blood-brain barrier. The key objectives of this 3-year grant are to: 1) Construct a spatiotemporal atlas of brain mural cells during development using single-cell RNA sequencing and tissue-based...

Federal Grant Award Summary Boston Children's Hospital received a $306,716 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective July 1, 2025, through October 2, 2028. The award funds research investigating the molecular mechanisms of neuronal primary cilia dysfunction in tuberous sclerosis complex (TSC), a genetic disorder characterized...

The National Heart, Lung, and Blood Institute (NHLBI) awarded UCLA a $534,761 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to develop magnetoelastic vascular grafts (MVGs) as an innovative platform technology for continuous stenosis monitoring. The MVG research aims to address a critical clinical need, as approximately 40% of the 3 million vascular grafts implanted annually experience reduced patency within two years. The project, running from September 1,...