Project Grant W911NF2310038

The National Institute of Mental Health (NIMH) awarded a $464,750 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to President and Fellows of Harvard College, also known as Harvard University. The purpose of this 2-year project, titled "GUT MICROBIOME CONTRIBUTIONS TO HUMAN EPISODIC MEMORY AND THE ROLE OF EARLY LIFE STRESS," is to identify the relationship between human gut microbiome composition, episodic memory performance, and the impact of early life...

The University of Miami was awarded a five-year, $549,140 Project Grant (R01MH136006) from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) to investigate the role of the bacterial quorum sensing molecule autoinducer-2 (AI-2) in mediating stress-related behaviors and neurobiological changes. The key objectives of the research are to: 1) determine if stress regulates gut bacterial production of AI-2, 2) assess the contribution of bacterial AI-2 to stress-related...

This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $719,917 to investigate the effects of chronic stress on cognitive flexibility and the underlying cellular mechanisms in the prefrontal cortex. The key objectives are to: Examine sex-dependent effects of chronic stress on cognitive flexibility and related changes in synaptic regulation and activity of specific neuronal subpopulations in the...

This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), is focused on elucidating the mechanisms by which gut microbiome dysbiosis impacts the transport of short-chain fatty acids (SCFAs) and its relevance to autoimmune disorders like multiple sclerosis (MS). The $863,500 award, spanning September 2024 to August 2026, will investigate how MS-associated gut...

This $825,135 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the Massachusetts General Hospital to investigate the relationships between gut microbiome-related metabolites, cerebrovascular disease, Alzheimer's disease biomarkers, and cognitive impairment. The research will leverage data from the REGARDS and CARDIA longitudinal cohort studies to examine associations between gut microbiome metabolites, brain imaging markers, and the...

This federal Project Grant award of $606,029.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research at the University of Massachusetts Medical School (UMass Medical) to investigate the neurocircuitry underlying motivated reward-seeking behavior in response to stress. The key goals of the research are to: 1) Determine if a subpopulation of GABAergic neurons in the medial habenulo-interpeduncular (MHB-IPN) axis...

The National Institute of Mental Health (NIMH) awarded a $787,584 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of North Carolina at Chapel Hill (UNC-CH) to study the neural and behavioral trajectories of executive function (EF) from infancy to emerging adulthood, and how these trajectories relate to functional brain organization and future psychopathology risk. The study aims to leverage UNC's unique longitudinal Early Brain Development Study cohort to chart...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $630,905 to the University of Wisconsin - Madison to explore the role of the gut microbiome-derived metabolite imidazole propionate (IMP) in the progression of Alzheimer's disease (AD) and related dementias (ADRD). The key objectives are to characterize the relationship between IMP, blood-brain barrier disruption, and AD pathology in mouse models, as well as determine the association between IMP...

This Project Grant awarded by the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to investigate how the gut microbiome composition impacts gastrointestinal (GI) and central nervous system (CNS) function in a mouse model of autism spectrum disorder (ASD). The $430,375 award to the partnership between Henry Ford Health and Michigan State University Health Sciences will...

This National Institute on Aging (NIA) Aging Research Project Grant (CFDA 93.866) award of $3,127,512 to the University of California, Los Angeles (UCLA) aims to investigate the protective effects of dietary polyphenol intake on cognitive function and brain-gut microbiome interactions in older adults at high risk of Alzheimer's disease (AD). The 5-year study will conduct a randomized, double-blind, placebo-controlled trial in 300 U.S. participants and a 100-person validation sample from Northern...