Project Grant W911NF1910435

Federal Project Grant Award Summary New York University School of Medicine received a $755,801 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 3, 2026, with completion targeted for January 31, 2031. The research project investigates the regulatory mechanisms controlling CD4+ and CD8+ T cell function through examination of the CLNS1A protein, a molecule critical to T...

This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) is providing $827,942.00 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to investigate a novel inhibitory receptor that regulates the persistence and function of chimeric antigen receptor (CAR)-engineered T cell therapy for lymphoma. The key objectives are to: 1) examine the causal role of this inhibitory receptor axis in impairing the therapeutic...

This Project Grant award of $735,078 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of Chicago to investigate the molecular mechanisms underlying innate immune memory and trained immunity in humans. The key objectives are to: 1) Characterize the epigenetic changes induced in human myeloid and lymphoid progenitor cells by trained immunity adjuvants, 2) Determine how these epigenetic...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $693,465 to Cornell University over a period from January 2025 to December 2029. The funding supports a research project titled "Mapping Infant and Adult T Cell Immunity" that aims to construct a molecular atlas of T cell development in lymph nodes and determine how cellular interactions and communication networks change during CD8+ T...

This federal Project Grant award of $737,502 was provided by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), to The Washington University in Missouri. The research project aims to investigate the role of the WDFY4 protein in regulating the development and function of regulatory T cells (Tregs), which are critical for maintaining immune tolerance. Specifically, the research will: 1) Determine the impact...

The University of Pittsburgh received a $679,937 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to conduct research on mechanisms and therapeutic targeting of T cell regulation in heart allograft recipient monkeys. The 5-year project aims to investigate the impact of cytokine modulation and administration of novel, donor-specific chimeric antigen receptor regulatory T cells (CARTREG) on promoting long-term...

The University of Washington received a $264,750 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to conduct research on the "Integrin-Mediated Regulation of Type-1 Dendritic Cell Positioning and Function in Lymph Nodes". The 2-year project, spanning April 2025 to March 2027, aims to explore how the CD11a integrin regulates the positioning and interactions of lymph node-resident dendritic cells (DC1)...

This $379,609 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports fundamental immunological research conducted by the University of Pittsburgh from May 2025 through April 2027. The grant funds investigation into B cell central tolerance mechanisms in response to commensal microbial antigens, specifically examining how the immune system establishes homeostasis with...

The Icahn School of Medicine at Mount Sinai was awarded a $532,970 Project Grant from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to conduct research on the role of CD4 helper T cells in promoting anti-tumor immunity and enhancing responses to PD-1 targeted immunotherapies. The 5-year research project aims to define the key cell-intrinsic features and cell interactions of anti-tumor CD4 T cells that can support effective anti-tumor immune responses, with a focus on...

Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Trustees of Columbia University in the City of New York a Project Grant totaling $764,591 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a five-year research project running from August 1, 2025, through July 31, 2030. This research initiative investigates the differential regulation of cell cycle entry and apoptosis in cytolytic lymphocytes, specifically...