Project Grant W81XWH2210725

This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $302,037 to Tissue Testing Technologies LLC to develop an ice-free vitrification and nanowarming method for preserving meniscal grafts used in transplantation. The project aims to optimize nanowarming techniques to maintain cell viability, gene expression, and extracellular matrix integrity...

This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $199,867 to the University of Washington to develop an innovative approach for long-term cryopreservation of organs using ice-free vitrification and single-mode electromagnetic resonance (SMER) heating. The project aims to overcome barriers in organ cryopreservation by advancing vitrification and EM heating technologies to enable fast and uniform rewarming of cryopreserved...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $1,930,758 to Sylvatica Biotech Inc., a minority-owned small business, to develop novel techniques for "enhanced supercooling" to enable ice-free preservation of clinical-scale livers at high subzero temperatures for over 72 hours. The goal is to significantly extend current liver preservation times...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is funding the development and testing of a "VentSafe" bidirectional synchronous flow-controlled ventilation system to improve oxygenation and ventilation in Acute Respiratory Distress Syndrome (ARDS). The $1,160,157 award to Liberandum Technologies, Inc. aims to design a ventilation system with lower potential for trauma and reduced...

Percassist Inc. received a $663,129 Project Grant award from the National Heart Lung and Blood Institute of the Department of Health and Human Services. The award was made under the Cardiovascular Diseases Research program (CFDA 93.837), which supports heart and vascular research. The grant funds the development of a percutaneous ventricular assist device for chronic heart failure patients. Specifically, Percassist will design and test a balloon catheter implant that can be delivered minimally...

The University of Massachusetts Medical School will deliver the Active Rejection Micro-Patch Surveillance (ARMS) System for Vascularized Composite Allografts under a $280,000 cooperative agreement awarded by the Defense Health Agency on September 30, 2022. The three-year award will support the development of a monitoring system to detect early signs of rejection in vascularized tissue transplants through the Military Medical Research and Development program (CFDA 12.420). This program aims to...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,386,770 to VON Vascular, Inc. to develop a novel aspiration pump for neurointerventional procedures. The goal is to create an improved aspiration pump that can increase first-pass revascularization rates and reduce medical waste, compared to existing market-leading devices....

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $275,739 project grant under the Cardiovascular Diseases Research (CFDA 93.837) program to WR Biotech, LLC, a small disadvantaged business. The grant supports research on a novel technique called Improved Synchronization Modulation Electric Field (I-SMEF) to protect donor hearts and improve transplanted heart graft function during cold storage prior to heart transplantation in mice. The I-SMEF technique aims to maintain...

The National Heart, Lung, and Blood Institute (NHLBI), under the federal Cardiovascular Diseases Research program (CFDA 93.837), awarded a $306,643 project grant to Mira Medical, LLC to develop a new extracorporeal membrane oxygenation (ECMO) pump designed to efficiently accommodate the low flow rates needed for pediatric and neonatal patients. The project aims to design, develop, and test a low-flow ECMO pump capable of operating at flow rates from 0.05 to 0.5 L/min, which is an order of...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $3,367,846 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Nour Heart Inc. to develop a novel bioenergetic drug called Nourexal (cyclocreatine phosphate, or CCRP) to increase donor heart utilization. The goal is to extend the time and distance that donor hearts can be transported, which could potentially increase heart transplant cases by over 3,000 per year. The 2-year project aims to: 1) produce...