Project Grant W81XWH2210540

Acatechol, Inc. was awarded a $274,982 National Science Foundation (NSF) Small Business Innovation Research (SBIR) Phase I grant to develop an innovative anti-infective coating for Foley catheters. The project aims to create a hybrid coating that combines biofilm-repellent and antimicrobial properties to provide prolonged resistance against pathogen colonization and catheter-associated urinary tract infections (CAUTIs). This work is being conducted under the NSF Technology, Innovation, and...

This Project Grant award from the Department of Health and Human Services National Institutes of Health (CFDA 93.310 Trans-NIH Research Support) is providing $323,850.00 to Watershed Medical Inc. to develop an innovative drug delivery platform for local delivery of the antibiotic amikacin to the bladder. The goal is to create a prophylactic solution to treat and prevent recurrent urinary tract infections (rUTIs) in post-menopausal women. Initial human studies have demonstrated the product's...

This Project Grant award of $356,032 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports the development of a novel bladder catheterization device. The project aims to create an innovative method for bladder drainage that addresses the significant morbidity and inconvenience associated with current catheterization approaches. Over 1 million Americans, including those with neurogenic bladder conditions, require catheter use for bladder drainage. The...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $234,750 to the University of Notre Dame to conduct research on polymicrobial interactions during catheter-associated urinary tract infections (CAUTI). The key objectives are to: Investigate the antagonistic effects of Escherichia coli (E. coli) against Candida albicans (C. albicans), specifically examining the...

This Project Grant award of $226,253 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate the adaptations of Staphylococcus aureus that enable its persistence within the bladders of long-term catheterized individuals. The research will be conducted by the University of Texas Health Science Center at Houston (UTHealth) from September 1, 2025 through...

The Defense Health Agency awarded a $1,523,243 Project Grant under the Military Medical Research and Development program (CFDA 12.420) to the Medstar Health Research Institute Inc. to evaluate the use of intravesical gentamicin coupled with the probiotic Lactobacillus rhamnosus for improving urinary health. The project will involve pre-clinical studies at Loyola University of Chicago and the University of Pittsburgh to determine the optimal administration protocols, as well as a pilot clinical...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $653,123 to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct a multi-center randomized trial comparing daily nitrofurantoin versus bladder fulguration plus daily nitrofurantoin for the long-term management of cystitis in women with recurrent urinary tract...

This $414,781 Project Grant awarded by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) will support research to investigate the effects of pelvic radiotherapy on the urinary microbiome and its potential as a biomarker for radiation cystitis in prostate cancer patients. The primary awardee, the University of Rochester, will use banked urine samples from a clinical study, as well as a preclinical mouse model, to test hypotheses that: 1) radiotherapy alters the microbial...

This $809,427 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the impact of polymicrobial interactions and within-host adaptation on the pathogenesis of catheter-associated urinary tract infections (CAUTI). The award recipient, The Research Foundation For The State University Of New York (RF SUNY) doing business as Sponsored...

This Project Grant award, provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), supports a study on the use of intravesical gentamicin coupled with Lactobacillus rhamnosus for urinary health. The total funding amount is $126,166.00, with the award date of September 1, 2024 and an ultimate completion date of August 31, 2027. The prime awardee is Medstar Health Research Institute Inc., a non-profit organization that has extensive...