Project Grant W81XWH2110960

This Project Grant from the National Institutes of Health's Trans-NIH Research Support program, totaling $2,844,000, will support the development of new chemical tools for selectively manipulating aggregate proteostasis in cells and in vivo using a targeted protein degradation approach. Funded from September 2022 through August 2025, the University of California, San Diego will apply technologies and concepts from targeted protein degradation cancer therapy research to central challenges in...

This federal Project Grant award for $381,251, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), will support research to understand how endoplasmic reticulum (ER) quality control processes, including ER-associated degradation (ERAD) and ER-autophagy (ER-phagy), regulate protein homeostasis in different cell types. The key objectives are to: 1) establish the principles governing the selection of...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support a systematic investigation of disease-associated, regulatory variation and its impact on the risk and progression of Parkinson's disease (PD). The $635,430 award will fund research to: 1) Define chromatin and transcriptional signatures in PD-vulnerable dopaminergic neurons over...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $682,493 to the Albert Einstein College of Medicine to elucidate the role of aberrant histone acetylation in the pathogenesis of Parkinson's disease and related synucleinopathies. The research involves utilizing a human pluripotent stem cell-based discovery platform...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to investigate the role of the GPNMB gene in the pathogenesis of Parkinson's disease, Lewy body dementia, and related synucleinopathies. The $655,329 award to the Albert Einstein College of Medicine aims to identify causal genetic variants that regulate GPNMB expression...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $246,248 to The Trustees of the University of Pennsylvania to investigate how disrupted autophagy contributes to the chronic inflammation and plaque formation associated with the progression of Alzheimer's disease (AD) and related dementias. The researcher will use AD risk variants...

This Project Grant award from the National Institute on Aging (NIA), part of the Aging Research program (CFDA 93.866), provides $1,275,512 to The Regents of the University of California, San Francisco (UCSF) to investigate how progranulin (PGRN) species contribute to the accumulation of TDP-43 protein in aging and neurodegenerative diseases like Alzheimer's and frontotemporal dementia. The research aims to: 1) test how PGRN species modulate TDP-43 proteolysis in vitro, 2) define the capacity...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $663,376 to The Regents of the University of California, San Francisco (UCSF) to conduct research exploring the differential spreading of distinct pathological conformers of proteins associated with Alzheimer's disease, Lewy body dementia, and related dementias. The project aims to identify candidate genes responsible for the selective regional vulnerability to these distinct pathological...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $499,286.59 to the University of Pittsburgh to conduct research on the relationship between the LRRK2 protein and oxidative stress in Parkinson's disease pathogenesis. The project aims to elucidate how wild-type LRRK2 kinase activity is stimulated, where in the cell this occurs,...

This Project Grant award for $866,764 from the National Institute on Aging's Aging Research Program (CFDA 93.866) supports an interdisciplinary research study at the University of California, San Francisco (UCSF) to investigate human-specific vulnerabilities and compensatory adaptations of midbrain dopaminergic neurons in response to age-related stressors. The project aims to leverage stem cell-derived organoids, primary tissue samples, machine learning, and CRISPR techniques to directly measure...