Project Grant W81XWH2110733

This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $199,867 to the University of Washington to develop an innovative approach for long-term cryopreservation of organs using ice-free vitrification and single-mode electromagnetic resonance (SMER) heating. The project aims to overcome barriers in organ cryopreservation by advancing vitrification and EM heating technologies to enable fast and uniform rewarming of cryopreserved...

Federal Grant Award Summary Florida International University has been awarded $1,419,436 under the Cardiovascular Diseases Research program (CFDA 93.837) administered by the National Heart, Lung, and Blood Institute (NHLBI) to develop innovative methods for ex vivo storage, preservation, and rehabilitation of living heart valves for allogeneic valve transplantation. The award, effective September 1, 2025, through May 31, 2030, addresses a critical clinical need for cardiac valve replacements...

Federal Grant Award Summary The National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a CAREER (Faculty Early Career Development) Project Grant of $650,267 to Massachusetts General Hospital, effective July 15, 2025 through June 30, 2030, under the Engineering program (CFDA 47.041). The primary deliverable is the identification and characterization of novel cryoprotective agents (CPAs) with reduced toxicity for use in cryopreservation...

The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $350,000 Project Grant to Karios Technologies LLC to develop TissueShield, a novel single-use, ready-to-use, sterile, dual-chamber, dual-syringe sprayable hydrogel for preventing post-surgical cardiac adhesions. TissueShield is a 3-component polymer system that can be easily sprayed directly onto the heart, forming a robust anti-adhesion layer within seconds. The...

This three-year, $162,238 Project Grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research between Yale University, Stony Brook University, and researchers at examining and developing biomimetic peptides that inhibit ice formation. The researchers aim to understand and mimic antifreeze proteins in nature to generate synthetic antifreeze molecules for applications such as biological material preservation, food processing...

Grant Award Summary Cryocrate LLC received a $292,963 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) on September 17, 2025, with completion targeted for August 31, 2028. The company is developing Odinsol, a novel polysaccharide-based cryopreservation medium designed to preserve natural killer (NK) cells for cancer immunotherapy applications. Unlike current cryopreservation methods that use toxic, cell-permeating cryoprotectants,...

This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program provides $304,906 to Seabird Lifesciences LLC for the development of a novel bioprinting approach to create vascular grafts. The project aims to produce a next-generation vascular graft that improves outcomes for patients undergoing vascular surgeries by enhancing tissue integration, improving long-term performance, and reducing the need for repeat...

The University of Colorado-Denver received a $624,000 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), effective April 1, 2026 through March 31, 2028. This award supports the development and validation of a novel ex vivo delivery technology designed to improve heart transplant outcomes and expand the usable donor organ pool. The project...

Insoma Bio, Inc. received a $252,992 National Science Foundation Engineering Division Project Grant to develop an injectable protein matrix to enhance the stability of autologous fat grafts. The goal of the one-year grant project, which runs from July 2021 through June 2022, is to create a biocompatible hydrogel scaffold for adipose tissue engineering that can improve the survival rate of fat transfer procedures. The NSF Engineering Division seeks to foster innovation in engineering research...

This three-year, $1.2 million project grant from the National Science Foundation's Engineering program (CFDA 47.041) will support research at Washington State University and Cornell University to develop new tissue engineering strategies for cartilage regeneration. The researchers aim to stimulate adult stem cells to become mature chondrocytes for cartilage production through small molecules that interfere with bone cell differentiation genes. Real-time imaging will monitor cell growth...