Project Grant W81XWH2110688

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $709,718 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Florida International University (FIU) to develop methods for storing and preserving living heart valve allografts ex vivo. The funding will support research to validate a biomimetic strategy for extended storage, preservation, and rehabilitation of living valvular allografts, with the goal of improving the availability, cost-effectiveness,...

This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $199,867 to the University of Washington to develop an innovative approach for long-term cryopreservation of organs using ice-free vitrification and single-mode electromagnetic resonance (SMER) heating. The project aims to overcome barriers in organ cryopreservation by advancing vitrification and EM heating technologies to enable fast and uniform rewarming of cryopreserved...

The U.S. Department of the Army Medical Command has awarded a $285,750 Project Grant under the Military Medical Research and Development (CFDA 12.420) program to Functional Circulation LLC in Lake Mills, WI. The funding will support the company's research on "Normothermic Machine Perfusion to Enhance Retinal Preservation of Whole Eye Allografts to Treat Absolute Blindness." The project aims to develop innovative techniques to preserve whole eye allografts using normothermic machine...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $275,739 project grant under the Cardiovascular Diseases Research (CFDA 93.837) program to WR Biotech, LLC, a small disadvantaged business. The grant supports research on a novel technique called Improved Synchronization Modulation Electric Field (I-SMEF) to protect donor hearts and improve transplanted heart graft function during cold storage prior to heart transplantation in mice. The I-SMEF technique aims to maintain...

The Project Grant award of $784,227 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The Ohio State University supports research to engineer an oxygen-carrying perfusate for normothermic machine lung perfusion. The goal is to address the critical shortage of viable donor lungs for transplantation by improving the assessment and potential resuscitation of donor lungs, particularly those from donation after circulatory death (DCD). The research...

The National Heart, Lung, and Blood Institute (NHLBI) awarded Vivacelle Bio Inc. a $559,138 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to develop their proprietary VBI-1 formulation as a novel treatment protocol for outpatient cardiac arrest. The grant supports further preclinical validation of VBI-1, a phospholipid nanoparticle suspension designed to restore effective blood flow, absorb nitric oxide/free radicals, and deliver oxygen to address cardiac...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $295,963 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to New Health Sciences, Inc. (Hemanext Inc.) to evaluate the hemostatic function of platelets stored under hypoxic conditions for whole blood (WB) transfusion. The project aims to develop an improved WB storage platform that maintains an oxygen-managed environment to provide higher quality red blood cells for oxygen delivery and shock reversal, while...

This $712,461 Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) supports Cryocrate LLC, a for-profit company based in Columbia, Missouri, in developing advanced biocompatible cryopreservation techniques for eyelid and periorbital tissues. The 3-year project, which began on September 15, 2025, aims to create innovative cryopreservation solutions to improve the viability and long-term storage of cells, tissues, and...

The federal Project Grant award of $889,188 from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research is funding the development of a new gas carrier technology called intravenous oxygen (IVO2) based on pH-responsive polymeric microbubbles (PMBs). The goal is to improve oxygen delivery and treatment of cardiac arrest, which affects approximately 700,000 patients annually in the U.S. with low survival rates. The PMB technology allows safe...

The Regents of the University of California, San Francisco (UCSF) received a $550,000 Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an advanced cryopreservation system for complex bioengineered tissues. The project aims to determine the thermodynamic and biological parameters needed for isochoric supercooling cryopreservation of three-dimensional tissues within a microgravity-optimized...