Project Grant W81XWH2110593

The National Institute on Drug Abuse (NIDA) awarded The Washington University a 3-year, $2,337,729 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to study the impact of prenatal opioid exposure on placental and fetal brain development. The project, titled "The Opioid in Pregnancy: Imaging of Oxygenation, Inflammation, and Development in Brain & Placenta" (OPIOID BPP), aims to define the longitudinal effects of prenatal opioid exposure on...

Federal Project Grant Award Summary The University of Pennsylvania received a $708,040 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded June 15, 2026, with completion targeted for March 31, 2031. This research initiative investigates distinct neural circuits underlying opioid dependence and pain, specifically examining how chronic opioid exposure induces maladaptive changes in the parabrachio-amygdalar...

This National Institutes of Health National Institute on Drug Abuse Project Grant award of $234,364.35 supports research from March 1, 2021 through August 31, 2022 at clinical practices of the University of Pennsylvania located in Pennsylvania. The research aims to characterize a nociception-active basolateral amygdala to anterior cingulate cortex circuit that contributes to affective-attention pain behaviors, and determine its overlap with endogenous mu opioid receptor systems. The grant also...

Federal Grant Award Summary Louisiana State University Health Sciences Center New Orleans received a $225,065 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective August 15, 2025, with a completion date of July 31, 2027. The award supports research on targeting the renin system as a novel therapeutic approach for managing chronic pain and opioid use disorder (OUD). The project leverages the FDA-approved...

Federal Project Grant Award Summary Albert Einstein College of Medicine received a $199,584 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded March 15, 2026, with completion targeted for February 28, 2031. Dr. Michele Buonora will conduct a five-year hybrid effectiveness-implementation study examining patient-controlled analgesia (PCA) for acute pain management in hospitalized individuals with opioid use...

The University of Pittsburgh received a $129,330 Project Grant from the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279) awarded on June 15, 2026, with a completion date of May 31, 2028. The grant supports research investigating spinal neural circuits recruited by descending facilitation from the rostral ventromedial medulla (RVM), with a focus on understanding how chronic stress amplifies pain through mu opioid receptor...

Federal Grant Award Summary Oregon Health & Science University received a $906,124 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective September 1, 2025, through May 31, 2030. The research initiative focuses on understanding the cellular mechanisms underlying opioid tolerance through investigation of mu opioid receptor (MOR) trafficking, endosomal recycling, and the retromer protein complex. The project...

Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Children's Hospital of Philadelphia (CHOP) a project grant totaling $352,540 under the Drug Use and Addiction Research Programs (CFDA 93.279) for the five-year period from August 1, 2025, through July 31, 2030. The project, titled "The Adolescent Surgery Experience: Preoperative Anticipatory Guidance and Postoperative Opioid Misuse," addresses the critical public health concern of opioid...

The National Institutes of Health (NIH) awarded Boston Medical Center Corporation a $2,573,346 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279). The 3-year grant, which commenced on September 1, 2023, will fund a prospective cohort study comparing 100 opioid-exposed pregnancies to 50 non-exposed controls. The study aims to: Compare serial microRNA (miRNA) signatures in opioid-exposed and control pregnancies using maternal plasma and placental tissue samples. The...

Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a five-year R01 Research Project Grant totaling $659,796 to the University of Maryland, Baltimore to conduct a rigorous, double-blind, placebo-controlled human laboratory trial examining the risks and therapeutic benefits of co-using opioids and gabapentin among individuals with chronic pain. The research will evaluate the effects of gabapentin and the opioid hydromorphone, administered alone and in...