Project Grant W81XWH2110563

This federal Project Grant award of $586,250 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research program supports research to investigate how distinct age-associated B cell subsets can protect the aged from influenza. The project aims to determine the potential of different age-associated B cell subsets to respond to influenza infection and generate antibody-secreting cells, B cell memory, and long-lived...

This $356,174 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to determine the efficacy of an active immunization strategy in preserving cognitive and neural function by slowing the formation of amyloid-beta (Aβ) or tau proteins in the brain, which are significant contributors to neurodegenerative diseases like Alzheimer's. The key activities supported under this 2-year grant include: 1) prophylactically immunizing 5XFAD and hTau transgenic mouse...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded Orlance, Inc., a woman-owned small business, a $300,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop an enhanced seasonal influenza DNA vaccine. The project aims to combine the advantages of a closely matched seasonal influenza vaccine with a universal influenza vaccine to provide more robust and durable protection, especially for the elderly and immunocompromised...

This $390,942 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop a universal influenza vaccine using self-assembled peptide nanoparticles (SAPNs). The key goals are to: Assemble and characterize SAPNs functionalized with highly conserved influenza antigens, including the hemagglutinin stalk (HRHA) and matrix protein 2 ectodomain (4M2E), on the external surface, and...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $230,000 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Scripps Research Institute to develop a broad-spectrum influenza vaccine. The goal of the project is to target the neuraminidase (NA) protein, which is engaged by broadly neutralizing antibodies that can provide protection against diverse influenza strains. The research will evaluate recently discovered NA broadly neutralizing...

This $3,056,673 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to investigate the immunological mechanisms that contribute to improved antibody response rates in people living with HIV (PLWH) when vaccinated with the Heplisav-B hepatitis B vaccine compared to the standard Engerix-B vaccine. The study has three key objectives: Define the innate immune signatures, including...

The University of Missouri System, under a $650,000 project grant from the USDA National Institute of Food and Agriculture (NIFA) Agriculture and Food Research Initiative (AFRI) program, is developing safe and effective live attenuated swine influenza vaccines using Newcastle disease virus (NDV) as the vector. The project aims to address the challenges with current swine influenza vaccines, which often fail to provide cross-protection against diverse virus strains. The key products and...

This $249,276 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) is funding a study on the real-world effectiveness of maternal respiratory syncytial virus (RSV) vaccination. RSV is a leading cause of lower respiratory tract infections in infants, contributing to 33 million episodes and 101,400 deaths annually. With no existing antiviral therapies or effective treatments,...

This $677,777 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a study examining the impact of HIV status, age, and chronic immune activation on responses to the pneumococcal conjugate vaccine (PCV20) among older adults living with and without HIV. The study will measure acute (30-day) and long-term (2-year) immune responses following PCV20 vaccination across four participant groups: 1) older adults living with HIV, 2) older HIV-uninfected...

This federal Project Grant award from the National Institute on Minority Health and Health Disparities (CFDA 93.307 Minority Health and Health Disparities Research) is intended to increase RSV vaccine uptake among Latino older adults. The $2,058,402 award to the Regents of the University of California, San Francisco will fund a 5-year research project to adapt and evaluate a community-based intervention involving community health worker counseling and text message nudges. The goal is to...