Project Grant W81XWH2010579

This Project Grant award by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $583,250 to The Schepens Eye Research Institute, Inc. to identify the mechanisms underlying ocular toxicity caused by nitrogen mustard exposure and evaluate specialized lipid mediators as potential medical countermeasures. The key objectives are to: 1) Determine how nitrogen mustard alters the function of conjunctival goblet cells and if...

This federal Project Grant award of $362,415 from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research to investigate the role of the orexin neurotransmitter system in regulating intraocular pressure (IOP) and its potential implications for glaucoma treatment. The research aims to: 1) examine the influence of the brainstem raphe pallidus on IOP elevations induced by stimulation of the dorsomedial hypothalamus/perifornical region, 2) assess the...

This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support (CFDA 93.310) program provides $498,248 to the University of Connecticut Health Center (UCHC) to investigate the molecular mechanisms underlying corneal and retinal injury caused by exposure to chemical threat agents like nitrogen mustard. The key objectives are to: 1) Examine the role of the p53-PAD axis in driving corneal hypercitrullination, a pathological response, after nitrogen...

This $589,071 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) is funding research to investigate the immune mechanisms driving chronic ocular damage after acute exposure to nitrogen mustard, a potent chemical warfare agent. The key objectives are to: (1) determine how the acute innate corneal response to mustard exposure activates a persistent pathogenic T-helper 17 (Th17) immune response, and...

This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), provides $1,426,622 to The Washington University in St. Louis to investigate the neural mechanisms underlying corneal injuries caused by ammonia exposure. The key objectives are to: Correlate ammonia-induced corneal nerve degeneration with delayed wound healing and quantify associated ocular pain in mouse models. Characterize the sensitivity and response profiles of...

This $568,122 Project Grant from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research at Baylor College of Medicine to unequivocally confirm the contribution of neurovascular dysfunction to glaucoma pathogenesis and identify endothelial cell-specific ligands with potential for neuroprotective therapy. The research aims to globally map all ligands binding to ocular hypertension and healthy retinal cells, quantify their binding activities, and...

This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), will provide $475,000 in funding to The Salk Institute for Biological Studies in La Jolla, CA. The goal of this 4-year research project is to characterize the connectivity and functional role of specific neural circuits in the mammalian visual system that transmit information from the retina to the primary visual cortex. The key products and services to be delivered include:...

This Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) provides $611,546 in funding to the University of California, Berkeley to conduct research on the neural mechanisms underlying sustained visual perception in humans. The key objectives are to: 1) investigate how attention and awareness affect persistent representations of visual stimuli, 2) analyze the structure and information content of field potentials and single neuron spikes in the...

This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), will support research to investigate the role of damaged mitochondrial DNA (mtDNA) and the DNA/RNA sensor ZBP1 in retinal ganglion cell degeneration in glaucoma. The $618,088 award, effective from February 1, 2025 to January 31, 2029, will be conducted by researchers at the University of Texas Medical Branch at Galveston. The project aims to test the hypothesis that...

The Department of the Army Medical Command awarded a $1,428,860 Project Grant to The Schepens Eye Research Institute, Inc. of Boston, MA under the Military Medical Research and Development program (CFDA 12.420) to investigate the safety and efficacy of supersaturated oxygen emulsion (SSOE) as a novel topical treatment for open globe injury. The three-year award beginning September 30, 2022 will support animal research using mice to test SSOE and controls supplied by sub-awardee Coruna Medical...