Project Grant W81XWH2010482

This $2,685,420 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support the commercialization readiness of immune mediator-based blood tests that inform current and future clinical disease activity in patients with systemic lupus erythematosus (SLE). The key products to be developed and validated through this late-stage research project are the Lupus Flare Risk Index (L-FRI)...

This Project Grant award of $788,508 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research into the links between cutaneous photosensitivity, systemic autoimmunity, and lymphatic dysfunction in systemic lupus erythematosus (SLE). The research aims to delineate the determinants of Langerhans cell (LC) licensing for lymphatic regulation, identify the...

This $173,556 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a five-year research study by Yale University to investigate the role of retroelements in the pathogenesis of systemic lupus erythematosus (SLE), a highly morbid autoimmune disease. The key objectives are to: 1) delineate gene and retroelement expression patterns as well as inflammatory cytokine levels in the blood and skin of SLE...

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $256,808.00 to the University of Washington to study the molecular mechanisms that cause and perpetuate systemic lupus erythematosus (SLE). The research aims to investigate how dysregulated mRNA splicing in SLE neutrophils can affect their function and generate novel autoantigens. Key objectives include...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research at the Benaroya Research Institute at Virginia Mason focused on understanding the role of FOXP3 isoforms in regulating autoantibody production and the development of systemic lupus erythematosus (SLE). The $709,019 award, effective November 19, 2024 through October 31, 2029, will fund studies to examine how...

This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA 93.846 Arthritis, Musculoskeletal and Skin Diseases Research provides $405,350 to The Feinstein Institutes for Medical Research to conduct research on the role of lipid droplets in macrophages and their consequences in lupus. The research aims to (1) characterize lipid droplets in macrophage subsets and (2) determine if manipulating the content or quantity of lipid...

This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $343,904.00 to The Regents of the University of California, San Francisco to investigate abnormal gene expression patterns in skin T cells of Asian and Hispanic patients with atopic dermatitis. The key objectives are to validate a set of elevated transcripts identified in these...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,330,897 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Benaroya Research Institute at Virginia Mason to conduct research on plasmacytoid dendritic cells and IgA autoantibodies in systemic lupus erythematosus (SLE). The research aims to determine the mechanisms by which IgA autoantibodies synergize with IgG autoantibodies to enhance plasmacytoid dendritic cell production...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $793,093 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Oklahoma Medical Research Foundation (OMRF) to conduct research on defining the regulatory landscape of systemic lupus erythematosus (SLE) and its comorbidity with cardiovascular disease (CVD). The research aims to identify genetic factors that contribute to both SLE and CVD by studying the impact of SLE-associated genetic...

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a Project Grant (CFDA 93.846) totaling $715,957 to Northwestern University to conduct research on the mechanisms underlying interferon-induced T peripheral helper (Tph) cell differentiation in systemic lupus erythematosus (SLE). The research aims to elucidate how high levels of circulating type I interferon contribute to the pathological expansion of Tph cells, which are associated with increased...