Project Grant W81XWH2010305

This $672,394.58 project grant from the National Institutes of Health's National Institute of Dental and Craniofacial Research Oral Diseases and Disorders Research program (CFDA 93.121) supports the development of a crosslinkable tissue particle implant for regenerating craniofacial bone. Led by Leefa Biotech LLC, the one-year award aims to demonstrate improved bone regeneration in critical-size cranial bone defects using the implant compared to the current standard of care. If successful, the...

Nostopharma LLC was awarded a $256,000 Small Business Technology Transfer Phase I Project Grant from the National Science Foundation to develop a sustained-release, biodegradable nanoparticle drug delivery system for treatment of soft tissue trauma complications. Funded under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), the 12-month project beginning March 1, 2022 aims to demonstrate in vitro and in vivo feasibility of modulating the ectopic bone microenvironment...

This federal Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to investigate the mechanisms behind varied success of bone morphogenetic protein-2 (BMP-2) in palatal versus mandibular bone repair. The $129,420 award to The Leland Stanford Junior University, which runs from March 2025 to February 2027, focuses on two key objectives: 1) identifying how BMP-2-based palatal...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Cooperative Agreement award to Reselute, Inc. provides $998,921 to develop a novel implantable orthopedic medical device and procedure to reduce recovery duration and infection risks associated with severe traumatic fractures of the long bones. The project aims to advance a 3D-printed, antibiotic-releasing intramedullary nail to improve upon current standard-of-care implants that are prone to...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Phase I Small Business Innovation Research (SBIR) project aims to develop a novel implantable system that leverages distraction osteogenesis as a treatment for diabetic foot ulcers (DFUs). The $295,000 award, effective from December 15, 2024 to August 31, 2025, supports the design and development of a low-profile implantable transverse tibial transport device. This device integrates an active mechanical...

This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is focused on developing a localized small molecule delivery system to improve tendon-to-bone integration following anterior cruciate ligament (ACL) reconstruction. The $1,060,925 award to The Trustees of the University of Pennsylvania will fund in vitro release studies to test the duration and...

This Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop a novel gene therapy for bone healing. The $454,050 award, effective February 1, 2025 through January 31, 2030, will support research to create an adeno-associated virus (AAV)-based gene therapy that delivers bone morphogenetic protein-2 (BMP-2) to heal critical-size bone...

This Project Grant award of $1,722,291.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund the development of novel metformin-releasing injectable scaffolds to enhance dental pulp stem cell-based regeneration of critical-sized craniofacial bone defects. The University of Maryland, Baltimore is the prime awardee. The key objectives are to: (1) demonstrate that metformin's osteogenic and...

This $1,816,884 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop, evaluate, and prepare regulatory paperwork for a new technique to guide implant placement in orthopedic surgery. The key products and services include: Developing a surgical navigation workstation to integrate a low-profile guidance robot with...

This Project Grant award of $312,871, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports the development of a novel pro-angiogenic bone coating hydrogel (ABC hydrogel) for the treatment of osteonecrosis. The key objectives are to: 1) determine the physical, chemical, and cytocompatibility properties of the ABC hydrogel; 2) optimize the pro-angiogenic...