Project Grant W81XWH2010180

Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital a $1.748 million Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to develop intravenous oxygen (IVO2) therapy for treating cardiac arrest. The grant, awarded May 21, 2025, with completion targeted for March 31, 2029, supports research on pH-responsive polymeric microbubbles (PMBs)—oxygen-carrying particles with polymer shells approximately...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Regents of the University of Michigan provides $445,144 in funding to examine the relationship between blood-based mitochondrial bioenergetic capacity in frozen samples, socioeconomic position, and physical functioning in older adults. The key objectives are to: 1) Test the reliability and validity of using the innovative Respirometry in Frozen Samples (RIFS) method to measure systemic markers...

Federal Project Grant Summary Rhode Island Hospital received a $651,380 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with a completion date of May 31, 2029. The grant funds research on coronary vascular resilience through modulation of mitochondrial reactive oxygen species (ROS) in endothelial cells. The primary deliverable is an investigation into molecular mechanisms...

Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $761,262 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) for research titled "Intravenously Injected Mesenchymal Stromal Cells Protect Against Acute Lung Injury by Transferring Mitochondria to Restore Endothelial Function." The award, effective September 1, 2025, through June 30, 2029, falls under the Cardiovascular Diseases Research...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is supporting research to develop mitochondrial-targeting exosomes (MTEs) containing anti-inflammatory microRNAs (MTE-miRNAs) to treat neuroinflammation. The $469,500 award to Michigan Technological University aims to restore mitochondrial function, reduce oxidative stress,...

This Project Grant award of $528,179, awarded by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research conducted by the University of Miami to investigate reprogramming of monocytes to improve neovascularization in peripheral arterial disease and critical limb ischemia. The key objectives are to: 1) determine if extracellular vesicles mediate the systemic effects of monocyte reprogramming, and 2) investigate how reduced expression of the...

Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $731,827 Project Grant to J. David Gladstone Institutes, effective September 1, 2025 through June 30, 2030, under the Cardiovascular Diseases Research program (CFDA 93.837). The research project, "Mechanisms of Oxygen Toxicity," focuses on understanding how excess oxygen (hyperoxia) damages cellular tissue across multiple disease states, including hyperoxic lung injury,...

This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a $560,000 research initiative led by Baylor College of Medicine to develop a "triple gene therapy" treatment for ischemic heart failure. The goal is to leverage a combination of three experimental approaches - inducing cardiomyocyte proliferation, direct cardiac reprogramming of fibroblasts, and increasing angiogenesis - to synergistically regenerate...

This $181,772 project grant from the National Heart, Lung and Blood Institute will support research into coagulopathy in sepsis patients. The grantee, Beth Israel Deaconess Medical Center, will conduct an ancillary study using viscoelastic monitoring to examine the effects of randomly assigned fluid resuscitation strategies on coagulation parameters in sepsis patients. Specifically, the study aims to: 1) analyze how liberal versus restrictive fluid administration impacts coagulation measurements...

This Project Grant award of $305,447, issued on September 2, 2024 by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research), aims to identify predictive biomarkers for acute intermittent hypoxia-induced motor recovery in individuals with incomplete spinal cord injury. The research team from the University of Colorado will: 1) Validate the cellular mechanisms underlying hypoxia-induced plasticity in humans, using...