Project Grant W81XWH1910080

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding research to develop and optimize a new animal model for Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). The $374,349 award to the University of North Carolina at Chapel Hill will support the creation of a CRISPR-integrated mutant mouse line that mimics...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to develop a novel cellular model for investigating amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will directly convert patient-derived fibroblasts into neurons, preserving the epigenetic age of the starting cells, in order to...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to assess Pison Technology's neural biosensor as a digital biomarker for characterizing disease progression in amyotrophic lateral sclerosis (ALS). The $459,097 award will fund the development of a wearable device that can remotely monitor physiological data from ALS patients, enabling...

This Project Grant award of $2,683,965.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund the development and optimization of an "all-human cellular system" for studying Alzheimer's disease (AD) and age-related dementias (ADRDs). The primary objectives are to: 1) define delivery conditions for introducing patient blood cells and plasma into a...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders provides $532,381 to Emory University to comprehensively investigate the molecular mechanisms underlying the role of the KIF5A gene variant KIF5ADE27 in the pathogenesis of amyotrophic lateral sclerosis (ALS). The key research objectives include: 1) determining the gain-of-function effects of KIF5ADE27...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $227,205 to Cedars-Sinai Medical Center to conduct research aimed at identifying pathological signatures and molecular markers in the motor cortex of patients with amyotrophic lateral sclerosis (ALS). The key objectives are to: 1) use advanced MRI techniques to correlate in vivo...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $387,525 to the University of Nevada, Reno to investigate the role of proton-mediated signaling at the neuromuscular junction in amyotrophic lateral sclerosis (ALS) models. The research aims to measure basal and activity-dependent pH transients in the neuromuscular junction...

The National Institute on Aging (NIA) awarded The Leland Stanford Junior University (Stanford University) a $428,563 Project Grant under the Aging Research Program (CFDA 93.866) to develop a modular cell-on-chip platform to study how neuronal activity regulates myelin sheath formation and how these dynamics are altered in neurodegenerative disease. The 2-year project will enable fine-tuning of neuronal stimulation, recording of extracellular activity, and high-resolution imaging of myelin...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to investigate the effects of re-expressing embryonic motor neuron selector transcription factors on amyotrophic lateral sclerosis (ALS) pathology. The $645,391 award, effective from December 1, 2024 to November 30, 2029, will be provided to The Trustees of Columbia...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports the development of a blood-based biomarker for characterizing disease progression and therapeutic response in amyotrophic lateral sclerosis (ALS). The awardee, Neurodex Inc., a small for-profit organization, is advancing the validation of an assay for measuring...