Project Grant W81XWH1610331

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Gelsana Therapeutics Inc. a $649,984 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) on September 5, 2024. The purpose of this grant is to support the development of Provasliex Gel, a zwitterionic hydrogel that delivers controlled release of platelet-derived growth factor (PDGF) to address impaired wound healing associated with diabetes. The goal is to demonstrate the...

Vivonics Inc., a medical technology company based in Massachusetts, received a $331,455 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to develop a near-infrared layered imaging system called NIR-LITH. This system aims to provide objective, three-dimensional hemodynamic mapping of diabetic foot ulcers and surrounding tissue with 1 mm depth resolution, improving clinicians' ability to assess wound healing potential and make more accurate...

This $367,577 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) to Adepthera LLC aims to develop a regenerative peptide therapy to accelerate pressure ulcer healing. Specifically, the award will fund research to identify an optimal formulation of a self-assembling adrenomedullin (ADM) analog gel that can improve local blood circulation and wound healing in aging and diabetic mouse models. The proposed therapy would be administered weekly or biweekly via...

This Project Grant award of $305,000 from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of an advanced wound care product for treating diabetic foot ulcers. The product utilizes a patented microneedle patch design to deliver three therapeutic agents that disinfect the wound, prevent bacterial biofilm formation, and activate the immune system to promote healing. Initial work will be conducted using skin tissue...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $268,377 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The University of North Texas Health Science Center at Fort Worth. The grant aims to develop and evaluate a novel device using high-frequency, low amplitude vibration (HFLAV) to accelerate healing of stage 2 diabetic foot ulcers (DFUs) and improve patient quality of life. Key objectives...

This $205,000 project grant from the National Institutes of Health's National Institute on Aging will fund research into the pathomechanics of diabetic foot ulcers at The University of Texas Southwestern Medical Center over a 12-month period. The research aims to identify more accurate markers and marker combinations for foot ulceration risk in patients with diabetic neuropathy and a history of prior ulcers. Using specialized equipment, the study will quantify two primary ulcer-causing...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Phase I Small Business Innovation Research (SBIR) project aims to develop a novel implantable system that leverages distraction osteogenesis as a treatment for diabetic foot ulcers (DFUs). The $295,000 award, effective from December 15, 2024 to August 31, 2025, supports the design and development of a low-profile implantable transverse tibial transport device. This device integrates an active mechanical...

This Project Grant award of $469,766 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) aims to develop a new technology for accelerating wound healing. The key products and services to be delivered under this award include: Conducting in-vitro cell culture studies to establish the cellular mechanisms by which nanogenerator-driven electrical stimulation (NG-ES) can enhance...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Emory University a 5-year, $555,034 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund the "Comprehensive Assistance and Resources for Effective Diabetic Foot Navigation (CARE-D-FOOT-NAV)" randomized controlled trial. The project aims to assess the effectiveness of a patient navigator program in improving diabetic foot ulcer...

The National Institute on Aging (NIA) awarded a $295,923 Project Grant (CFDA 93.866 - Aging Research) to Larix Bioscience LLC to develop novel hormonal therapeutics and study their efficacy with adult stem cells for the treatment of chronic pressure ulcers. The project aims to generate stable, bioactive hormone fusion biologics and evaluate their ability to enhance tissue regeneration in pressure ulcer patients, both alone and in combination with adipose-derived or induced pluripotent stem...