Project Grant U282M190020

This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $315,533 to support the ABCD-REPRONIM educational program. The program aims to train researchers in responsible and reproducible analyses of data from the Adolescent Brain Cognitive Development (ABCD) study. Key products and services include: A 16-week online course providing didactic training on topics such as statistical and socioenvironmental...

This $737,732 federal Project Grant award was provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Trustees of Columbia University in the City of New York, with a period of performance from July 2024 to March 2029. The project aims to study the causes and consequences of DNA replication stress in the mammalian preimplantation embryo. The research will focus on identifying the...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is funding research at the Sloan-Kettering Institute for Cancer Research to investigate the molecular mechanisms of eukaryotic chromosome replication. The $1,350,554.00 award will support a 5-year research project that aims to elucidate the intrinsic mechanisms of the eukaryotic DNA replication machinery and its response to various...

This Project Grant award, identified as R01GM152613, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The award, totaling $680,400.00, will fund research at The University of Texas M.D. Anderson Cancer Center in Houston, TX to investigate the link between replication fork protection and the innate immune response. The key objectives of this 4-year project are to: 1) delineate how...

This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $245,504 to the University of North Carolina at Chapel Hill. The project aims to explore a novel approach for targeting the stress-specific function of the replication protein A (RPA) complex to enhance treatment responses in oral squamous cell carcinoma (OSCC). Key research activities include developing...

This $3,422,481 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) will support a comprehensive genomic research program at Children's Mercy Hospital to characterize novel causes of unexplained recurrent pregnancy loss (RPL). The program will leverage the hospital's large clinical RPL service and existing Genomic Answers for Kids (GA4K) pediatric rare disease database to procure carefully...

This Project Grant award from the U.S. Department of Health and Human Services Health Resources and Services Administration (HRSA) under the Grants for Education, Prevention, and Early Detection of Radiogenic Cancers and Diseases program (CFDA 93.257) provides $419,432 in funding to the Tuba City Regional Health Care Corporation (TCRHCC) to continue its Radiation Exposure Screening and Education Program (RESEP). The funding will enable TCRHCC to enhance RESEP's educational outreach, conduct...

This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) provides $716,587 to Boston Children's Hospital to advance equity in rare disease genomic research. The key objectives are to: Develop and implement a Diversity, Equity, and Inclusion toolkit within the Broad Institute's Rare Genomes Project to improve engagement and participation from historically underrepresented populations in rare disease genomic studies. This will involve...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $358,000 in funding to Brigham & Women's Hospital Inc. to conduct research on overcoming epigenetic barriers to somatic cell reprogramming by the XPC DNA repair complex. The key focus of the research is to understand how the XPC protein regulates DNA demethylation and gene expression changes mediated by the TDG enzyme, and how...

This Project Grant from the Department of Health and Human Services' National Institutes of Health Office of the Director, under the Trans-NIH Research Support program (CFDA 93.310), provides $2,043,753 to the University of Wisconsin-Madison for the RESET project running from April 15, 2021 to March 31, 2022. The RESET project aims to increase safe in-person school attendance among children with medical complexity (CMC) through three complementary approaches. It will establish the feasibility of...