Project Grant SISNDF22GR0010

This Cooperative Agreement, awarded by the U.S. Centers for Disease Control and Prevention (CDC) under the Global AIDS program (CFDA 93.067), provides $11,097,080 to Global Health Systems Solutions (GHSS) to build laboratory capacity and improve quality of HIV testing services in the Democratic Republic of the Congo (DRC). The key objectives are to: 1) scale up quality assurance and improvement for HIV rapid testing and TB testing; 2) increase coverage and timeliness of viral load, early...

This Project Grant award of $1,011,348 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand how interactions between Mycobacterium tuberculosis (M.TB) and the human alveolar environment, particularly in people living with HIV, impact the early stages of TB infection. The key objectives are to: 1) Determine how M.TB exposure to alveolar lining fluid from people living with...

The National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program has awarded a $1,487,500 Cooperative Agreement to the University of California, Davis to establish the Center for Insights into the Pre-Emergence Phase of Pandemics (CI3P). This multi-year project aims to develop innovative scientific and technological solutions to detect signals of pathogens circulating in natural reservoirs and provide insights into how pandemic threats emerge. The key objectives include:...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $209,750 to Emory University to leverage antibody-omics technologies to prevent and detect tuberculosis (TB) in children affected by HIV. The key objectives are to: 1) Define antibody Fc features associated with protection from Mycobacterium tuberculosis (MTB) infection in infants with and without maternal HIV exposure, and 2) Identify...

This $15,083,516 Project Grant award from the National Institutes of Health (NIH) under the Construction Support program (CFDA 93.352) will fund the modernization of high and maximum containment research facilities at the National Emerging Infectious Diseases Laboratories (NEIDL) at Boston University. The key goals are to: 1) modify biosafety level (BSL)-3 and animal BSL-3 spaces to enable isolated room decontamination and maintenance, 2) renovate arthropod containment spaces to increase...

This $534,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to develop wastewater surveillance systems for monitoring multidrug-resistant bacteria (MDRB). The key objectives are to: Establish standardized wastewater surveillance strategies to inform clinical infection control responses, using long-read metagenomics and novel bioinformatics to rapidly identify significant changes in...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $382,852 to Brown University to develop methodological innovations for improving the use of observational causal inference models to estimate the population-level impact of interventions on infectious disease outcomes. The key products and services to be delivered include: Proposing robust specifications for observational...

This $1,062,500 Cooperative Agreement award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports the "Pandemic Environmental Surveillance Center for Assessing Pathogen Emergence (Pandemic ESCAPE)" project. The primary goals are to: 1) Advance environmental surveillance (ES) technology, data interpretation, and adoption to enable widespread deployment across the U.S.; 2) Train the next generation of ES scientists; 3) Accelerate ES adoption as a...

This Project Grant award of $781,129 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a 5-year study to validate and extend an integrated host-microbe (IHM) diagnostic approach for accurately diagnosing lower respiratory tract infections (LRTIs) in critically ill children. The study aims to: 1) validate the performance of the existing IHM LRTI diagnostic classifier, 2) develop a novel host gene expression...

This $233,250 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to develop improved methods for detecting multi-strain and cryptic clade Clostridioides difficile (C. difficile) infections. The primary objectives are to: 1) Identify combinations of growth conditions and selective pressures to optimize recovery of multiple and cryptic clade C. difficile strains from stool...