Embedded entrepreneur to commercialize active stimulation/monitoring technologies to optimize pain and nociception management during regional anesthesia, general anesthesia, and post-operative care…

The National Institute of Neurological Disorders and Stroke awarded Pascall Systems, Inc. $199,806 on July 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to commercialize active stimulation and monitoring technologies for optimizing pain and nociception management during regional anesthesia, general anesthesia, and post-operative care.

The award funds development of technology using event-related potentials (ERPs) to actively assess pain and analgesia during surgical procedures. Current monitoring methods are unreliable because existing products use indicators susceptible to intraoperative influences such as blood loss and anesthetic drugs. Regional anesthesia techniques lack direct efficacy assessment and may fail during surgery, leaving anesthesiologists without real-time nociception monitoring. The proposed technology addresses this gap by enabling ERP-based pain assessment, though ERPs present technical challenges—their amplitude ranges from approximately 1 to 10 microvolts and is overshadowed by background electroencephalogram oscillations 10- to 100-fold larger during general anesthesia.

Work is performed in Boston, Massachusetts. The period of performance runs from July 1, 2026, through June 30, 2028.

Pascall Systems specializes in neuroscience-based medical technology focused on anesthesia and brain monitoring systems. The company has previously received federal grant funding to develop wireless EEG-guided monitoring technologies for elderly and neurologically vulnerable patients, with emphasis on preventing post-operative delirium.

Embedded entrepreneur to commercialize active stimulation/monitoring technologies to optimize pain and nociception management during regional anesthesia, general anesthesia, and post-operative care - surgery and acute post-operative pain are major contributors to persistent pain, chronic pain, and opioid dependence. Currently, there are no products on the market in the united states that can be used to monitor surgical nociception. Existing products use indicators that are susceptible to intraoperative influences such as blood loss, anesthetic drugs and antihypertensives. This leaves anesthesiologists to guess whether or not the analgesic therapies they are providing will be effective at managing intra-operative nociception and subsequent post-operative pain. A significant fraction of surgeries also rely on regional anesthesia techniques, and, these techniques are not foolproof, and may fail during surgery, leading to potentially uncontrolled postoperative pain that is apparent only when the patient recovers consciousness after surgery in intense pain. As IT stands, anesthesiologists have no way to directly assess the ongoing efficacy of their regional blocks, leading to unreliable nociception and pain management. Therefore, improved methods to monitor surgical nociception are clearly needed. The original grant proposed to develop new technology that makes IT possible for the first time to use event-related potentials (ERPS) to actively assess pain and analgesia during general and regional anesthesia. ERPS are generated by painful stimuli and can be measured at the scalp by averaging waveforms from repeated stimuli generated by a variety of methods including electrical stimulation. ERPS are challenging if not impossible to use for anesthesia monitoring because they are very small, between ~1 to 10 microvolts, and are overshadowed by background electroencephalogram oscillations that are 10- to 100-fold larger in amplitude during general anesthesia or sedation. Recently, we developed a novel technology for processing ERPS that increases their precision ~150-fold even in the presence of orders-of-magnitude larger background oscillations. Building on our original grant's achievement, we need to fill gaps in business expertise within the current small business leadership by hiring an experienced entrepreneur to attract private funding through private investment and partnership with industry