Project Grant SB1NS147475
- Federal Grant Award Summary Pascall Systems, Inc. received a $5.99M Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded September 20, 2025, with completion targeted for May 31, 2027. The award funds the commercialization of PASCALL M1, an intraoperative electroencephalogram (EEG)-guided precision anesthesia management system designed to prevent postoperative delirium in elderly patients and those at risk for Alzheimer's disease and related...
- Federal Project Grant Award Summary Aventusoft LLC received a $1,049,565 Small Business Innovation Research (SBIR) Phase I project grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 5, 2025, with completion targeted for February 28, 2027. The funding supports the development and clinical validation of PainVitals, an artificial intelligence-powered wearable physiological sensor system...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke awarded the University of Connecticut $6.95 million under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop SmartStim, a novel implantable neuromodulation system designed to treat chronic pain by reversing underlying neural sensitization rather than merely masking symptoms. The award, dated August 15, 2025, with a completion date of July 31, 2028, funds translational development of...
- Federal Project Grant Award Summary Alcamena Stem Cell Therapeutics, LLC received a $3.0 million Project Grant from the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279) awarded on August 7, 2025, with an ultimate completion date of July 31, 2027. The grant supports Phase 1 development and FDA-guided preclinical and safety studies for ASCT-83, a first-in-class, non-opioid cell and tissue-permeable peptide therapeutic designed...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Connecticut a Project Grant totaling $8,044,252 under the Drug Use and Addiction Research Programs (CFDA 93.279) for development of implantable, degradable drug delivery devices for non-opioid post-surgical pain management. The award, effective September 15, 2025, through August 31, 2028, addresses a significant clinical need: approximately one in nine Americans undergoes...
- Summary of Federal Project Grant Award The National Institute of Neurological Disorders and Stroke awarded the University of Pittsburgh $129,330 on June 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research investigating spinal circuits involved in descending pain facilitation and chronic pain development. The research will employ advanced neuroscience techniques, including spatial transcriptomics and multiphoton imaging, to identify and characterize...
- Federal Project Grant Award Summary Function Therapeutics Inc. received a $499,863 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 11, 2025, with a completion date of August 31, 2027. The award supports research and development of parmodulins, a novel class of small molecule therapeutics designed to treat neuropathic pain without abuse potential. The project involves...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke awarded The Ohio State University a $10.1 million Project Grant on September 12, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to fund MODEL-PAIN: MOdeling Diverse Experiences and Longitudinal Trajectories of Pain. The four-year award, with an ultimate completion date of August 31, 2029, supports a prospective observational study of 2,400 emergency department patients to...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Leland Stanford Junior University a $423,500 Project Grant (CFDA 93.853: Extramural Research Programs in the Neurosciences and Neurological Disorders) effective June 1, 2026, through May 31, 2028. The award funds research to dissociate neural representations of pain and salience using intracranial human brain recordings. The research will obtain intracranial electroencephalography (iEEG)...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
Federal Grant Award Summary Pascall Systems, Inc. received a $199,806 Project Grant from the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279) for the period July 1, 2026, through June 30, 2028. The company is developing active stimulation and monitoring technologies designed to assess pain and nociception management during regional anesthesia, general anesthesia, and post-operative care. The core innovation involves utilizing event-related potentials (ERPs)—brain-generated electrical signals in response to painful stimuli—to enable direct, real-time monitoring of surgical nociception (pain perception) and analgesic effectiveness, addressing the current clinical gap where anesthesiologists lack objective tools to verify whether pain management therapies are working during surgery or to detect regional anesthesia failures before patients recover in post-operative pain. This technology development is particularly relevant to the Drug Use and Addiction Research Programs' mission, as improved intraoperative and post-operative pain management directly supports efforts to reduce chronic pain development and associated opioid dependence. By providing anesthesiologists with reliable nociception monitoring capabilities, the technology aims to optimize analgesic dosing and prevent inadequate pain control, thereby reducing the progression from acute surgical pain to chronic pain conditions and minimizing opioid reliance during post-operative recovery.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $199.8k | 7/1/26 |