Project Grant SB1NS135787

Teliatry Inc. received a $768,138 project grant award from the National Institutes of Health's National Institute of Biomedical Imaging and Bioengineering to develop a minimally invasive, single incision, rechargeable spinal cord stimulation system for chronic pain management. The grant was awarded under the Discovery and Applied Research for Technological Innovations to Improve Human Health program. Through this award, Teliatry will engineer the world's smallest (0.75cc), most cost-effective...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $3,565,780 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop a groundbreaking high-frequency trans-spinal magnetic stimulation (HF-TSMS) system for the non-invasive treatment of neuropathic pain. The funded project aims to create an HF-TSMS tool that can target neural pathways involved in...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $6,522,833 Project Grant to The Leland Stanford Junior University to conduct a mechanistic randomized clinical trial investigating the central and peripheral nervous system mechanisms of pain relief induced by peripheral nerve stimulation (PNS) for the treatment of refractory chronic neuropathic pain. The 3-year study, funded under the NIH HEAL Initiative's CFDA 93.279 Drug Abuse and Addiction Research Programs, aims...

This SBIR Phase I Project Grant, awarded by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program, is developing a novel minimally invasive procedure for deploying an implantable spinal cord stimulation (SCS) lead using a shape memory polymer (SMP). The $304,259 project, which runs from October 1, 2025 to June 30, 2026, aims to create an 8-channel SMP-based paddle lead that can be molded into a compact configuration for minimally...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), provides $3,473,616 to the University of Connecticut to develop a novel implantable neuromodulation system called "SmartStim" to treat chronic pain. The goal is to create a combined device and drug treatment that can selectively block sensitized nociceptive (pain-sensing) nerve fibers, especially C-fibers, to reverse the underlying neural...

The National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), awarded a $818,360 Cooperative Agreement to the University of Southern California (USC) to develop new highly potent and safe Angiotensin AT2 receptor (AT2R) antagonists for the treatment of neuropathic pain. This 4-year project aims to optimize a novel lead series of AT2R antagonists that have demonstrated better potency and...

This Cooperative Agreement award from the National Institute of Neurological Disorders and Stroke (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $3,242,520.00 to the University of Pittsburgh to quantify the safety and feasibility of a fully implanted spinal cord stimulation (SCS) system to treat phantom limb pain (PLP) in people with lower-limb amputation. The primary goal is to restore sensation in the missing limb and reduce PLP, which affects over 70% of people with...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $399,870 to 2Morrow Inc. to accelerate the commercialization and dissemination of their evidence-based digital behavioral therapeutic for individuals with chronic pain. The funding will be used to hire a fractional Chief Commercial Officer (CCO) to review and validate 2Morrow's commercialization plan, and then execute a...

The U.S. National Institute of Neurological Disorders and Stroke (NINDS) awarded a $399,954 Project Grant to Highland Instruments Inc. under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to expand the commercialization readiness of its Electrosonic Stimulation (ESStiM) technology. ESStiM is a noninvasive brain stimulation modality developed by Highland Instruments to treat chronic pain associated with carpal tunnel syndrome. The grant funding will enable Highland Instruments to...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), provides $540,427 to support a research project titled "Modeling Mechanisms of Interindividual Variation in Pain Modulation by Spinal Cord Stimulation." The project aims to use biologically-motivated mathematical models to investigate the mechanisms underlying variability in the efficacy of spinal cord stimulation (SCS) for chronic pain...