Project Grant RM1HG007743

The Department of Energy Office of Science awarded a $200,000 Project Grant to Photonlab of Fairfield, CA for its "NOVEL POSITION SENSITIVE PHOTOSENSOR TECHNOLOGY FOR RARE DECAY AND RARE PARTICLE DETECTION" project. The one-year project period runs from February 14, 2022 to February 13, 2023. Under this award, Photonlab will develop novel position sensitive photosensor technology to support rare decay and rare particle detection, in alignment with the Office of Science Financial...

Mesa Photonics LLC was awarded a $256,500 Project Grant from the Department of Energy Office of Science under the Office of Science Financial Assistance Program (CFDA 81.049) to support work on RESOLUTION-ENHANCED COHERENT NONLINEAR MICROSCOPY OF PLANT TISSUES. The grant will fund the development of new microscopy techniques using nonlinear optical and coherent imaging methods to image plant tissues with resolutions exceeding the classical diffraction limit. The work will leverage the...

The National Institute of General Medical Sciences (NIGMS) awarded Trestle Optics LLC a $305,647 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to develop a novel photothermal microscopy system for non-destructive, high-resolution screening and sorting of microalgae to identify and enrich strains producing high-value polyunsaturated fatty acids. The project aims to engineer and prototype a microfluidic platform integrating photothermal imaging...

The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $404,117 Project Grant to Panluminate Inc., a woman-owned small business, to develop CHROMEX30, a novel variant of their proprietary Pan-Expansion Microscopy (PAN-EXM) technology. This project aims to enable nanoscale (sub-10 nm) imaging of genetic organization and disease phenotypes using a standard confocal microscope, which addresses a key challenge in the field...

This Project Grant award of $749,227 from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) to Trustees of Boston University will fund the acquisition of a state-of-the-art three-photon microscopy system with fluorescence and phosphorescence imaging capabilities. This multi-user facility at Boston University's Neurophotonics Center will enable NIH-funded investigators to study deep brain structure and function in vivo, advancing research on normal...

The National Institute of General Medical Sciences (NIGMS) awarded a $333,048 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. in Houston, TX. The goal of this 1-year project is to develop a versatile 2-photon microscopy platform, dubbed 2P-SPOTLIGHT, to isolate individual cells from 3D tissue samples and 3D cell cultures based on their spatial and temporal properties. This will enable researchers to conduct downstream multi-omics...

This Project Grant award, valued at $400,000, was provided by the National Science Foundation (NSF) under its Computer and Information Science and Engineering (CISE) program (CFDA 47.070). The award supports the development of innovative "snapshot computational imaging" systems that leverage recent advances in metaoptics, or optical devices using sub-wavelength nano-structures, to capture multidimensional information about light interactions with the world. The key objectives of this...

This $390,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support the development of a multiparametric fluorescence microscopy framework to correlate metabolic changes with cellular manipulations and physical/biophysical properties. The award, granted to Georgetown University, will establish a seamless workflow to quantify and correlate fundamental cellular interactions, such as...

This $400,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund research to develop an integrated computational framework for predicting and designing "photoenzymes" - enzymes that can utilize light to catalyze non-natural chemical reactions important for pharmaceutical synthesis. The key products or services to be delivered include: 1) Machine learning-enhanced...

The National Institute of General Medical Sciences (NIGMS) awarded a $290,536 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Trestle Optics LLC, a small disadvantaged business, to develop a novel high numerical aperture catadioptric lens for ultra-broadband multimodal microscopy. This lens will enable advancements in existing nonlinear optical imaging modalities, such as three-photon excited fluorescence and third-harmonic generation, by overcoming limitations of...