Project Grant RF1NS145403
- Grant Award Summary The National Institute on Aging awarded a $5.16 million Project Grant to the University of California, Davis on September 1, 2025, under the Aging Research program (CFDA 93.866) to investigate environmental exposures and their relationship to brain health and Alzheimer's disease and related dementias (ADRD). The project, which extends through August 31, 2029, will deliver research services examining how smartphone Global Positioning System (GPS)-based exposure data to...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the Regents of the University of Michigan $1.7 million on April 1, 2026, under the Aging Research program (CFDA 93.866) to investigate environmental exposures and Alzheimer's disease and related dementias (ADRD) in the Health and Retirement Study (HRS) cohort. The project, with a completion date of January 31, 2031, will generate a publicly available, prospective environmental chemical resource by performing...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded University of Miami a $2.27 million Project Grant on September 15, 2025, under the Environmental Health program (CFDA 93.113) to investigate the relationship between urban heat island exposure and Alzheimer's Disease and Related Dementias (ADRD) outcomes among older adults in South Florida through April 30, 2030. The research will deliver three primary products: (1) investigation of...
- Federal Project Grant Award Summary Case Western Reserve University's Office of Research Administration received a $431,750 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective January 1, 2026, through December 31, 2027, to conduct biomedical research on the role of CHCHD10 protein in tauopathy associated with Alzheimer's disease (AD) and frontotemporal lobar degeneration with tau pathology (FTLD-TAU). The research will deliver...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded University of Maryland, Baltimore a $3.26 million Project Grant on September 15, 2025, under the Aging Research program (CFDA 93.866) to conduct research investigating olfactory dysfunction as a predictor of fine particulate matter (PM2.5) exposure progression to dementia. The research initiative will operate through August 31, 2029, and will deliver scientific research products advancing understanding of how...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $1,625,947 to the University of Rochester to conduct research on the relationship between air pollution-derived iron exposure, poverty-related stress, and Alzheimer's disease risk. The key objectives are to evaluate whether ambient and subway-level iron exposure leads to...
- Federal Project Grant Award Summary Cleveland Clinic Lerner College of Medicine of Case Western Reserve University received a $877,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct fundamental neuroscience research on N6-methyladenosine (M6A) methylation patterns in multiple sclerosis (MS). Awarded on May 6, 2026, with completion...
- Federal Project Grant Award Summary Case Western Reserve University received a $442,750 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective May 15, 2025, with a completion date of April 30, 2027. The research focuses on developing synthetic replicas of tau-dependent protein 43 (TDP-43) filaments associated with frontotemporal dementia and related neurodegenerative diseases. The primary deliverables include an experimental model...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Harvard T.H. Chan School of Public Health a $1.77 million Project Grant (CFDA 93.853: Extramural Research Programs in the Neurosciences and Neurological Disorders) on May 6, 2026, for research titled "The Impact of Environmental Factors on Lewy Body Dementia: Combining Claims Data and Mechanistic Studies." The three-year project, concluding April 30, 2029, will deliver rigorous...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health program (CFDA 93.113), awarded Icahn School of Medicine at Mount Sinai a Project Grant of $819,506 (awarded June 1, 2026; completion March 31, 2031) to assess pathway-specific stroke risks through the integration of generative artificial intelligence (AI), environmental exposure analysis, and population health data. The research addresses critical knowledge gaps regarding...
Federal Project Grant Summary Case Western Reserve University, in collaboration with Houston Methodist and University Hospitals Cleveland, received a $1.88 million Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). Awarded on June 9, 2026, with completion targeted for May 31, 2029, this multi-institutional research initiative investigates the mechanistic links between external environmental exposures—including air pollution, natural environment features, social determinants, and built environment characteristics—and Alzheimer's Disease and Related Dementias (ADRD). The research leverages preliminary data linking particulate matter air pollution and PM2.5 exposure to AD progression and associated molecular pathways. The funded research delivers two primary research products: (1) development and validation of an integrated environmental exposure fingerprint using deep-learning frameworks that incorporate air pollution, satellite imagery, street-level imagery, and clinical data to predict ADRD risk across the UK Biobank, U.S. Veterans Health Administration cohorts, and regional U.S. health systems, stratified by urban versus rural location, social vulnerability, and risk factor burden; and (2) creation and validation of an artificial intelligence pipeline to derive retinal microvascular and brain morphoradiomic measures from fundus photography and 3T brain MRI imagery to evaluate mediating mechanisms linking environmental exposures to ADRD development. The investigation examines relationships between environmental exposures, cognitive function, and cerebrospinal fluid biomarkers in aging subjects enrolled in the Emory Healthy Brain Study.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.9m | 7/14/26 |