Project Grant RF1NS128865

Award Date 8/1/22
Completion Date 7/31/25
Dollars Obligated $4.9M
Funding Federal Agency
National Institute on Drug Abuse
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
Cambridge, MA 02138, USA
Similar Awards
This $1,836,842 Project Grant from the National Institute of Neurological Disorders and Stroke will support research into sensory-motor strategies for odor-guided navigation. Funded under the Extramural Research Programs in the Neurosciences and Neurological Disorders program, the Trustees of Boston University will conduct research to better understand how spatial information is encoded in the olfactory bulb during odor-guided search behaviors in mice. Researchers will use new imaging tools to...
This federal Project Grant award for $271,422, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop an integrative framework for measuring and understanding the role of biomolecular condensates (BMCs) in the regulation of gene expression within olfactory neurons. The key objectives are to: 1) Define the spatial and molecular composition of BMCs in olfactory neurons, 2) Formulate a neural network model to...
This federal Project Grant award of $378,800.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support the development of computational modeling and simulation tools to study mouse forelimb movements for neuroscience research. The key products to be delivered include: A computational model based on optimal control theory to estimate muscle activity from kinematics and electromyography data, which can help reduce the number...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $383,521.00 to support research on the acoel worm Hofstenia miamia as a new model system for neuroscience. The key objectives are to: Develop methods for quantifying worm behavior and its aquatic environment, including using pose estimation, water flow measurement, and prey tracking. Perturb the organism and environment to uncover mechanisms of...
This $373,300 Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will support research to investigate the role of the nucleus accumbens (NAc) in learning and responding to reward-predictive cues. The research aims to enhance understanding of the neural activity dynamics in NAc that contribute to selective conditioned responses to reward-paired cues versus neutral cues. Using an auditory Pavlovian...
This Project Grant award, titled "DISSECTING THE NEURAL CIRCUIT MECHANISMS THAT GENERATE DOPAMINE NEURON ACTIVITY", is funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $656,073 award, effective July 15, 2024, supports research by Harvard University's President and Fellows to uncover how neural circuits generate dopamine neuron activity and reward prediction error signals. The project aims to examine the roles of...
This federal Project Grant award of $417,861.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to investigate the neural mechanisms underlying individual differences in reward-based learning strategies and their relationship to addiction-like behaviors. The research will focus on the role of dopamine signaling in the basolateral amygdala in mediating the emergence and expression of Pavlovian reward...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $120,015 to support research on the algorithmic and neural circuit basis of dopamine-driven learning in the striatum. The research aims to identify the mechanisms by which dopamine release drives reward-based learning, with a focus on using artificial conditioning tasks and optical stimulation of dopamine axons to isolate the effects of...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding a $1,373,618 research project titled "NEUROBEHAVIORAL SIGNATURES OF SIGN- AND GOAL-TRACKING IN EMERGING ADULTS: TRANSLATION OF A PRECLINICAL MODEL." The primary objective is to further validate a human sign-/goal-tracking paradigm and identify neurobehavioral signatures associated with sign-tracking and goal-tracking behaviors...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is providing $121,364 to the University of California, Los Angeles (UCLA) to conduct critical investigation into the neural circuitry that supports goal-directed and habit learning. The research will use advanced techniques such as optogenetic manipulation and in vivo fiber photometry to study the role of dopaminergic projections from the ventral...

This three-year, $4.93 million project grant from the National Institute on Drug Abuse will fund research into odor trail tracking behavior in mice. The grant supports three principal investigators at Harvard University who will study the algorithms and neural circuits underlying active sensation and continuous decision-making during this olfactory navigation behavior.

The researchers will use behavioral, physiological, molecular and computational methods across three aims. In Aim 1, they will characterize mice strategies for tracking odor trails using a high-throughput system and identify involved brain regions. Aim 2 focuses on uncovering relevant neural circuits and cell types in olfactory cortical areas through targeted neural activity measurement, viral tracing and transcriptomics. For Aim 3, the investigators will develop and test theoretical frameworks of behavioral strategies like sector searching and bilateral processing, informed by experimental data from Aims 1-2 to elucidate underlying neural algorithms.

A $250,000 subaward to Ecole Normale Superieure will support the participation of co-PI Professor Massimo Vergassola for modeling and theoretical work, as well as hiring a postdoctoral fellow for computational analysis. The research is funded through the National Institute on Drug Abuse's Drug Abuse and Addiction Research Programs (CFDA 93.279).

Generated 1/6/24, 9:09 PM