Mesoscale bidirectional two-photon holographic optogenetics
Ended Project Grant Awarded Last action
- Award ID
- RF1NS128772
- Recipient
-
The Regents Of The University Of California UEI GS3YEVSS12N6 Part of State Of California Controllers Office
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $3,176,798
Award facts
- Assistance listing
- 93.865 Child Health and Human Development Extramural Research
- Completion date
- Funding agency
- National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services
- Place of performance
- California, USA
Award details come from USAspending.gov.
Description
- Abstract
- Achieving a detailed understanding of the neural codes of sensation, action, and cognition requires technologies that can causally perturb each of the major dimensions of population coding one at a time with extremely high precision across multiple brain areas. Existing control systems do not fully meet this challenge because they are unidirectional and have limited spatial scale, speed, or resolution. To address this need, we will develop an all-optical holographic brain interface that can precisely and bidirectionally alter neural population activity across large volumes of tissue and with extremely high speed. We will build and validate a two-color two-photon holographic microscope and mesoscope and optimize single transcript bidirectional optogenetic tools. Leveraging a new form of ultra-fast sequential holographic illumination, we will obtain cellular-scale, independent bidirectional control over the spiking of hundreds to thousands of neurons across millimeters of brain tissue. Finally, we will develop online approaches that use this new system to precisely and selectively manipulate endogenous interneuronal correlations, neural spike timing, and tuning one at a time. This new technology will allow neuroscientists to distinguish which features of the neural code are causal in neural computation and behavior and which are merely incidental.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $376,798 | |
| Original award | $2,800,000 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Sorbonne Universite | $217,404 | |
| Sorbonne Universite | $632,480 |
Quick answers
Who received award RF1NS128772?
RF1NS128772 was awarded to The Regents Of The University Of California by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on August 16, 2022.
How much is award RF1NS128772 worth?
$3,176,798 has been obligated on RF1NS128772.
Which agency awarded RF1NS128772?
National Institute of Neurological Disorders and Stroke (National Institutes of Health) awarded RF1NS128772, with funding from National Institute of Child Health and Human Development (National Institutes of Health).
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