Project Grant RF1AG094791
- The National Institute on Aging awarded Michigan State University (doing business as Henry Ford Health+Michigan State University Health Sciences) $314,000 on April 1, 2026, under the Aging Research program (CFDA 93.866) to optimize and validate detection and modeling of the vascular and glymphatic systems in cerebral waste clearance using superparamagnetic iron oxide-enhanced susceptibility weighted imaging (SPIO-SWI), and to investigate cerebral waste clearance changes during Alzheimer's...
- The National Institute on Aging awarded Rush University Medical Center $656,503 under CFDA 93.866 (Aging Research) on September 1, 2026, to develop and validate an in-vivo MRI-based classifier for detecting cerebral amyloid angiopathy in community-dwelling older adults. The project combines multimodal MRI imaging with neuropathological data to create a machine-learning classifier capable of identifying cerebral amyloid angiopathy—a common age-related pathology affecting up to 80 percent of older...
- The National Institute on Aging awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $2,139,309 for a Project Grant (R01AG094755) on April 15, 2026, under the Aging Research program (CFDA 93.866). The recipient will develop advanced high-resolution MRI methods to noninvasively track cerebrospinal fluid flow and soluble amyloid-beta diffusion through perivascular spaces in the brain. The project tests three specific aims: developing and optimizing novel MR...
- The National Institute of Neurological Disorders and Stroke awarded Case Western Reserve University $1,884,854 on June 9, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate external environmental determinants of Alzheimer's disease and related dementias. The award funds a multi-institutional collaborative study examining mechanistic links between air pollution, natural and social environmental exposures, and ADRD in...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,156,262.00 to Case Western Reserve University's Office of Research Administration Division (doing business as University Hospitals of Cleveland) to conduct research on the role of N6-methyladenosine (m6A) RNA modification dysregulation in the pathogenesis of Alzheimer's disease. The research aims to determine how reduced expression of the m6A methyltransferase enzyme METTL3...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Rutgers, The State University $573,035 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the control of cerebrospinal fluid hydrodynamics and brain-waste clearance mechanisms. The research examines how the glymphatic system facilitates the clearance of neurotoxic proteins such as amyloid-beta and tau, which accumulate in aging and neurodegenerative diseases including...
- The National Institute on Aging awarded the Regents of the University of Michigan $284,108 on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how mechanical changes in the aging brain affect microglial function and Alzheimer's disease progression. The project explores the relationship between age-related mechanical alterations in brain tissue—specifically decreased stiffness and increased viscoelasticity resulting from reduced tissue connectivity—and microglial...
- The National Institute on Aging awarded Sri International $1.259 million under the Aging Research program (CFDA 93.866) on September 15, 2025, for a project grant investigating glymphatic magnetic resonance imaging and biomarker discovery in aging individuals living with HIV infection through August 31, 2027. The research examines dysfunction of the brain's waste clearance system (the glymphatic system) as a contributor to cognitive decline in older people with HIV. The project uses non-invasive...
- The National Institute on Aging awarded Case Western Reserve University $691,999 on March 15, 2026, under the Aging Research program (CFDA 93.866) to identify modifiers of tau seeds in human brain tissue and characterize cellular mechanisms that exacerbate or alleviate tau seeding across disease states. The recipient will detect and quantify tau seeds in human brain samples from diseased, clinically normal, young, and aged donors using ultrasensitive real-time quaking-induced conversion...
- The National Institute on Aging awarded New York University $466,125 under the Aging Research program (CFDA 93.866) on January 15, 2026, to develop innovative magnetic resonance imaging analysis tools for identifying microstructural biomarkers of skeletal muscle health across the lifespan. The project, titled "(Micro)structural Biomarkers of Skeletal Muscle Health Across the Lifespan," addresses sarcopenia—a leading cause of disability and mortality in aging populations—by creating...
The National Institute on Aging awarded Case Western Reserve University $3,153,437 on August 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate novel MRI methods for quantitative assessment of glymphatic function in the aging brain. The project will develop a three-dimensional magnetic resonance fingerprinting technique for dynamic, simultaneous tracking of oxygen-17 enriched water as a cerebrospinal fluid tracer and gadolinium-based contrast agents to measure glymphatic system efficiency in waste clearance from the central nervous system. The work addresses gaps in current neuroimaging tools: while dynamic contrast-enhanced MRI using gadolinium-based contrast agents has advanced understanding of cerebrospinal fluid transport at the whole-brain level, their large molecular size limits penetration into brain parenchyma and direct assessment of solute removal from brain interstitium. This project will enable comprehensive characterization of cerebrospinal fluid–interstitial fluid exchange and solute clearance dynamics. The underlying research objective targets age-related decline in glymphatic function and its contribution to neurodegenerative diseases, with investigation of how neurovascular coupling—the relationship between neural activity-induced hemodynamic changes and cerebrospinal fluid flow dynamics—changes with age and whether lifestyle interventions such as aerobic exercise training enhance waste clearance efficiency in aging brains. The award runs from August 1, 2026, through July 31, 2030. Work is performed at Case Western Reserve University in Cleveland, Ohio, operating through the Office of Research Administration in affiliation with University Hospitals of Cleveland.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.2m | 7/31/26 |