AI-adrd: accelerating interventions of ad/adrd via machine learning methods

Ended Project Grant Awarded Last action

Award ID
RF1AG077820
Recipient
Awarding agency
Obligated
$2,348,869

Award facts

Assistance listing
93.866 Aging Research
Completion date
Place of performance
Philadelphia, PA 19104, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Alzheimer's disease and alzheimer's disease related dementias (ad/adrd) are neurodegenerative diseases characterized by progressive loss of cognition and other neurobehavioral symptoms. In united states, there are approximately 5.8 million patients live with ad/adrd, and 97% of these patients are older than 65. In the last decade, real-world data (RWD), including electronic health records (EHR) data and claims data, are becoming increasingly valuable for drug repurposing of ad. In this proposal, we plan to develop novel high dimensional semi-supervised learning and active learning methods, as well as associated high dimensional hypothesis testing procedures, to accelerate interventions of ad/adrd, using drug repurposing of ad/adrd as a motivating use case. We will address several key challenges in real-world data including the high dimensionality of the risk factors, concomitant medication use, and complex and heterogeneous progression trajectories of ad/adrd. The success of this project will lead to novel machine learning and statistical learning methods for facilitating drug repurposing for ad/adrd based on real-world data.

Transactions

Action Obligated Date
Amendment $0
Original award $2,348,869

Subawards

Subrecipient Amount Awarded
Trustees Of Indiana University STATEMENT OF WORK Dr. Bian will co-direct the project as MPI, be responsible for the overall scientific direction of the project, and be responsible for the… $83,831
Regenstrief Institute Inc. Regenstrief Data Services (RDS) serve as the centralized gateway for researchers to access data from the Indiana Network for Patient Care (INPC), Indiana… $40,825
Lehigh University The overarching goal of this project is to develop novel high-dimensional semi-supervised learning and active learning methods, along with associated hypothesis… $45,160
Regenstrief Institute Inc. "Regenstrief Institute, Inc. is an internationally recognized informatics and healthcare research organization. It is a dynamic, people-centered research… $51,607
Lehigh University "The overarching goal of this project is to develop novel high-dimensional semi-supervised learning and active learning methods, along with associated… $61,554
Trustees Of Indiana University Dr. Bian will co-direct the project as MPI, be responsible for the overall scientific direction of the project, and be responsible for the budget and management… $100,892
Cornell University "Dr. Yang Ning, Assistant Professor in the Department of Statistics and Data science at Cornell University, will serve as a PI of the project and will devote… $247,199
University Of Florida Dr. Bian will co-direct the project as MPI, be responsible for the overall scientific direction of the project, and be responsible for the budget and management… $186,050
Cornell University Dr. Yang Ning, Assistant Professor in the Department of Statistics and Data science at Cornell University, will serve as a PI of the project and will devote 2… $231,992

Quick answers

Who received award RF1AG077820?

RF1AG077820 was awarded to The Trustees Of The University Of Pennsylvania by National Institute on Aging (National Institutes of Health) on May 1, 2023.

How much is award RF1AG077820 worth?

$2,348,869 has been obligated on RF1AG077820.

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