This federal Project Grant award, totaling $182,249, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant will fund a study titled "Implementation of a Digitally Enhanced Intervention to Retain Pregnant and Postpartum People with Opioid Use Disorder in Buprenorphine Treatment" at the Medical University of South Carolina. The overall objective is to evaluate the feasibility and implementation of the...
This federal Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) totaling $945,397 provides funding to the Magee-Womens Research Institute and Foundation, with a sub-award to the University of Pittsburgh, to adapt and evaluate a collaborative care model (CCM) for treating pregnant persons with opioid use disorder (OUD) in low-resource obstetric settings. The key objectives are to: 1) adapt the CCM for rural and low-resource...
The National Institute on Drug Abuse (NIDA) awarded The Washington University a 3-year, $2,337,729 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to study the impact of prenatal opioid exposure on placental and fetal brain development. The project, titled "The Opioid in Pregnancy: Imaging of Oxygenation, Inflammation, and Development in Brain & Placenta" (OPIOID BPP), aims to define the longitudinal effects of prenatal opioid exposure on...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $196,236 to The Washington University to conduct research focused on disparities in the prescription and effectiveness of medications to treat opioid use disorder (OUD) during pregnancy. The key objectives of the 5-year project are to: 1) evaluate how race and racial segregation are associated with the use of buprenorphine and methadone as well...
The National Institute on Drug Abuse (NIDA) awarded Magee-Womens Research Institute and Foundation a $3,092,159 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to conduct a multimodal analysis of gestational health and placental injury in opioid-affected pregnancies. The goal is to investigate the direct impact of illicit and prescription opioids on placental development, differentiation, and function, focusing on the critical syncytiotrophoblast and...
This $6,439,263 federal Project Grant awarded by the National Institute on Drug Abuse (CFDA 93.279 Drug Abuse and Addiction Research Programs) aims to determine the impact of maternal substance use on maternal immune activation, placental function, and offspring neurobehavioral development. The project will leverage the Healthy Brain and Child Development (HBCD) study to perform maternal immune profiling, placental and cord blood analysis, and novel neuroinflammation imaging on 400 pregnancies...
The National Institute on Drug Abuse (NIDA) awarded a $2,427,126 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Washington State University (WSU) to study culturally adapted Contingency Management (CM) interventions for stimulant use disorders among American Indian and Alaska Native (AI/AN) populations. The grant aims to rapidly implement culturally responsive interventions to address the high rates of fatal poisonings from methamphetamine and fentanyl among...
This National Institute on Drug Abuse (NIDA) Project Grant award under CFDA 93.279 (Drug Use and Addiction Research Programs) provides $390,635 to the University of Pittsburgh to develop a novel intervention that addresses prenatal depressive symptoms to encourage tobacco and cannabis cessation among marginalized pregnant and postpartum people. The key products and services to be delivered through this grant include: 1) Conducting formative research on the experiences of marginalized pregnant...
The National Institute on Drug Abuse (NIDA) awarded a $306,528 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Addinex Technologies, Inc. The grant will fund the development of a medication adherence and monitoring system to support decentralized clinical trials for substance use disorder (SUD). The project aims to adapt Addinex's existing medication management system to provide researchers running SUD clinical trials with a tool for at-home dispensing that...
The National Institute on Drug Abuse (NIDA) awarded a $1,076,018 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Dynamicare Health Inc. in Wareham, MA. The award will fund a Phase II randomized clinical trial to evaluate the efficacy of DCH-003, a digital therapeutic that delivers contingency management for the treatment of stimulant use disorder. The trial will compare standard clinic care plus DCH-003 to standard care plus a sham digital app, with the...
The National Institute on Drug Abuse (NIDA) awarded a $1,873,868 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Washington University in St. Louis. The grant is for the "Substance Use in Pregnant People - Optimizing Retention in Treatment by Maximizing Opportunities for Management (SUPPORT-MOM)" project, which aims to develop and test the efficacy of contingency management (CM) interventions to improve substance use disorder (SUD) treatment retention among pregnant patients.
The project has two phases. In the R61 planning phase, the grant will fund the development and pilot testing of: 1) a standardized protocol to address patients' social needs, and 2) a protocol for delivering CM in the Clinic for Acceptance, Recovery, and Empowerment (CARE) at Washington University. In the R33 phase, 270 patients will be recruited and randomized to usual care or the CM program. The study will assess the efficacy of CM to improve treatment retention, SUD outcomes, and the relationship between social needs, CM, and SUD outcomes. The grant also includes an exploratory aim to assess implementation outcomes. Two sub-awards have been issued to the University of Maryland, Baltimore and Saint Louis University to provide expertise in the development and implementation of the CM intervention.