California hub for HIV/STI/SUD prevention research with reentry populations

Ended Project Grant Awarded Last action

Award ID
R61DA060626
Recipient
Awarding agency
Obligated
$2,442,846

Award facts

Assistance listing
93.279 Drug Use and Addiction Research Programs
Completion date
Originally
Place of performance
California, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The period following release from incarceration is associated with increased risk for HIV and STI acquisition and transmission and fatal drug overdose. Implementation of effective programs for linkage to pre-exposure prophylaxis (PREP) for HIV, screening for HIV/stis/ hepatitis C virus (HCV), and rapid SUD treatment and harm-reduction services in reentry populations is needed to counteract these harms. Scale up of such programs may help to address racial/ethnic disparities in these outcomes given the overrepresentation of black and latino people, sexual and gender minority people, and people who inject drugs in jails and prisons. The proposed research hub will study the implementation of a demonstrated-effective, 6-month intervention designed to increase PREP use and HIV/STI/HCV testing following reentry, in three high-priority california counties. The mobile enhanced prevention support or meps intervention combines evidence-based strategies, including peer mentors, cash incentives, and a mobile application for facilitating access, goal tracking, and receipt of incentives. In the first (R61) phase of the project, we will adapt the meps implementation to practical realities of new agencies in new areas. In the second (R33) phase, we will conduct a type 3 hybrid implementation-effectiveness study using a stepped-wedge design to evaluate the adapted meps intervention in riverside, SAN bernardino, and alameda counties. Our academic-community partnership will also provide infrastructure for robust stakeholder engagement and support of pilot studies related to prevention during reentry. Our study aims are to: 1) pilot the following aspects of the meps trial in one county: participant recruitment and enrollment; baseline needs assessment and client-centered planning sessions; retention and follow-up assessments; specimen collection for PREP adherence monitoring; and peer mentor identification and training for the full intervention. 2A). Formalize partnerships with community agencies in each county and plans and adaptations for implementation of meps and the trial in their sites. 2B). Develop a set of common core measures with community and justice system partners and other components of the nida HIV/justice research network. 3) conduct a type 3 hybrid effectiveness trial, implementing the adapted meps intervention in the 3 counties, with 300 participants. Use the RE-aim framework and proctor's implementation science outcomes with a subset of participants, agency staff, and stakeholders to examine meps' implementation and a step-wedge trial design to assess intervention effectiveness for increasing PREP uptake and adherence (self-reported and tenofovir levels in hair), HIV testing, and SUD service utilization. 4) create and deploy a website as a community commons, with integrated research and communications utilities designed to meet the study coordination, community engagement, and implementation needs of hub partners in aims 1-3; disseminate findings related to meps intervention scale-up and other hub activities, (e.g., pilot studies); and support the sustainability and breadth of intervention adoption and knowledge production.

Transactions

Action Obligated Date
Amendment $0
Amendment $0
Amendment $0
Amendment $0
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Amendment $0
Amendment $790,247
Amendment -$790,247
Amendment $814,282
Amendment $814,282
Original award $814,282
Show all 11

Subawards

Subrecipient Amount Awarded
Starting Over Inc. 1) General a. Identify staff and 1-2 people with lived experience who can participate in planning processes across all five years of the study b. Support data… $36,801
Christ-Centered Ministries The LARRP team will provide input into all study activities. Specific roles are further detailed below: 1) Help to identify and engage community and criminal… $33,725
Charles R. Drew University Of Medicine And Science 1) Conduct data analyses, with a focus on analyses related to participants in and outcomes of the MEPS intervention trial.2) Provide methodological expertise… $54,580

Quick answers

Who received award R61DA060626?

R61DA060626 was awarded to University Of California, LOS Angeles by National Institute on Drug Abuse (National Institutes of Health) on May 15, 2024.

How much is award R61DA060626 worth?

$2,442,846 has been obligated on R61DA060626.

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