Project Grant R50CA305793
- The National Institutes of Health Office of the Director awarded The University of Chicago $137,760 under the Trans-NIH Research Support program (CFDA 93.310) on September 1, 2026, to develop and translate statistical software tools for genomics research. The award funds development of high-quality statistical software addressing three areas where existing tools are lacking: fine-mapping of health- and disease-related quantitative trait loci (QTLs), including molecular QTLs; gene set...
- The National Institute of Environmental Health Sciences awarded The Broad Institute, Inc. $387,000 on August 1, 2026, under the Medical Library Assistance program (CFDA 93.879) to develop bioinformatics and computational methods for integrative structure-function analysis of CRISPR base-editor tiling mutagenesis experiments. The project will create scalable bioinformatics pipelines to link base-editor library data and screening results to protein sequence-structure-function relationships,...
- The National Institutes of Health National Human Genome Research Institute awarded Oregon Health & Science University $2.737 million on September 1, 2026, under the Human Genome Research program (CFDA 93.172) to develop high-throughput and cost-effective single-cell multiomic technologies for DNA methylation analysis. The project will develop new strategies to measure DNA methylation alongside other cellular properties at high throughput, leveraging cell encapsulation technology to achieve...
- The National Institute of General Medical Sciences awarded Beth Israel Deconess Medical Center, Inc. $158,600 on January 23, 2027, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct single-molecule dissection of hypomethylation-driven genome instability. The research combines technology development with mechanistic chromatin biology to address how global DNA hypomethylation—an early epigenetic alteration in human cancer—drives chromosomal instability and DNA...
- The federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,507,500 to the University of Massachusetts Medical School (UMass Medical) to expand the capabilities of third-generation DNA/RNA sequencing technologies. The project aims to generate rapid and cost-effective training libraries to allow for direct detection of common DNA damage and RNA modifications, enabling innovative...
- Federal Grant Award Summary Icahn School of Medicine at Mount Sinai received a $462,454 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective August 8, 2025 through June 30, 2027. The award supports research investigating DNA methylation (5-methylcytosine) dynamics in Down syndrome (trisomy 21) hematopoiesis and leukemia development. The primary deliverable involves mapping epigenetic...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Vanderbilt University $752,875 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate the fate and function of regulatory ribosome collisions. The research constructs a high-throughput reporter library to determine the fate of disome-inducing elements—ribosome collision complexes that act as signaling hubs in protein synthesis quality control. The...
- The National Institutes of Health National Human Genome Research Institute awarded the Rector & Visitors of the University of Virginia $248,999 on May 11, 2026, under the Human Genome Research program (CFDA 93.172) to develop computational methods for modeling cell-cell interactions using spatial transcriptomics and single-cell multiome data. The project creates a series of computational frameworks to identify and characterize cell-cell interactions—the signaling events between sender and...
- The National Institute of General Medical Sciences awarded The Broad Institute, Inc. $464,032 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods for mapping intercellular circuits governing complex tissues, specifically mucosal epithelia in the intestine, airway, nose, urogenital tract, and related barrier surfaces. The project addresses two key analytical challenges: uncovering intercellular regulatory signals that...
- This $1,559,700 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) funds research by the Benaroya Research Institute at Virginia Mason (BRI) to investigate how genetic and epigenetic factors influence T cell function in autoimmune diseases. The key objectives are to: 1) use CRISPR-interference screening to identify regulatory regions that impact T cell proliferation and migration, 2) apply single-cell...
The National Institutes of Health Office of the Director awarded the Van Andel Research Institute $190,764 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop and improve research software for DNA methylation and RNA sequencing analysis. The award funds a research software engineer in Dr. Hui Shen's laboratory to enhance existing bioinformatics tools. Specific deliverables include removing unused code from BISCUIT (a whole-genome bisulfite sequencing analysis tool), improving the speed of DNA methylation extraction from aligned BAM files, and creating a testing framework. The engineer will simplify DUPSIFTER by recoding how bisulfite strands are delineated and add functions for differentiating unique molecular indexes in duplicate read signatures. Additional work will improve RNA-seq analysis tools. The existing software suite—including BISCUIT, BISCUITEER, DUPSIFTER, and BISPLOTTI—has achieved significant adoption, with BISCUIT and DUPSIFTER combined downloaded more than 23,700 times via Bioconda and BISCUITEER downloaded more than 9,000 times via Bioconductor from more than 2,700 unique IP addresses. Performance occurs at the Van Andel Research Institute in Michigan from September 1, 2026, through August 31, 2029. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $190.8k | 8/31/26 |