Project Grant R44TR006068
- The National Center for Advancing Translational Sciences at the National Institutes of Health awarded Onca Bio, Inc. $697,696 on September 15, 2025, under CFDA 93.350 (National Center for Advancing Translational Sciences) to develop segmented in vitro translation (SIVT) technology for expanding peptide library diversity in mRNA display applications. Onca Bio will apply SIVT to overcome a key limitation in current mRNA display macrocycle libraries, which are constrained by fixed residues at two...
- The National Institute of General Medical Sciences awarded Epitune LLC $350,000 on September 16, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an imaging-based platform for single-cell analysis of human-induced pluripotent stem cell identity. The platform combines microscopic imaging of epigenetic landscape, advanced image analysis, picowell arrays, and fluidic devices to enable rapid, affordable assessment of hiPSC identity at single-cell resolution....
- The National Institute of Biomedical Imaging and Bioengineering awarded North Carolina State University $1.292803 million on June 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop new methods for generating high-performance aptamers for in vivo monitoring of small molecules. The research aims to advance nucleic-acid-based synthetic receptors that offer advantages over antibodies for molecular sensing,...
- The National Institute of General Medical Sciences awarded Boston Interactome, Inc. $349,753 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop the Integrated Two-Hybrid (I2H) platform for protein-protein interaction mapping and drug discovery. Boston Interactome will develop I2H as a next-generation PPI detection platform combining multiple protein expression backgrounds and detection modes to achieve 80–90% coverage of protein-protein...
- The National Center for Advancing Translational Sciences awarded Emory University $860,750 on August 1, 2026, under the NCATS Research Exploration & Refinement (R21) grant program (CFDA 93.350). Emory will develop two complementary, patient-derived experimental systems to interrogate SMAD4-I500V hyperppi and identify small-molecule modulators to normalize TGF-β signaling in Myhre syndrome. The first system is the Myhre iPSC Hyperppi Biosensor System (MIBS), which will use...
- Summary Active Motif, Inc. received a $306,094 Project Grant award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), with performance extending from September 20, 2025, through August 31, 2026. The award funds the development of a novel epigenetic editing platform that utilizes an innovative targeting approach to recruit epigenetic effectors to specific genomic loci. This platform enables targeted alterations to the epigenome and...
- The National Center for Advancing Translational Sciences awarded Sollus Therapeutics, Inc. $322,576 on July 1, 2026, under the NCATS program (CFDA 93.350) to develop a modular, high-throughput screening platform for optimizing chimeric antigen receptor (CAR) designs. The project addresses limitations in CAR T cell therapy by creating a platform to systematically screen and optimize CAR architectures across antigens, diseases, and modalities. Work focuses on three aims: screening large...
- The National Institute of General Medical Sciences awarded Xgenomes Corp. $349,280 on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop machine learning algorithms for single molecule localization microscopy (SMLM) video analysis. Xgenomes will build three deliverables over the Phase I project period. In Aim 1, the recipient will create an SMLM video simulator to generate training data for machine learning models. In Aim 2, Xgenomes will...
- The National Institute of General Medical Sciences awarded the University of California Santa Cruz $425,033 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to map variant histone protein interactions and elucidate the molecular mechanisms governing those interactions through advanced proteomics and structural biology. Over the five-year performance period (July 1, 2026 through April 30, 2031), the principal investigator will use nucleosome...
- The National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health, awarded The Broad Institute, Inc. $436,250 on May 1, 2026, under the NCATS program (CFDA 93.350) to develop and validate the RAPID (Rare Disease Analysis Through Pooled Image-Based Identification of Drugs) platform for drug repurposing in rare disorders. The Broad Institute will develop a massively parallel screening platform that integrates pooled optical variant identification,...
The National Center for Advancing Translational Sciences awarded Epicypher, Inc. $1.062 million on September 1, 2026, under the NCATS Project Grant program (CFDA 93.350) to develop Small Molecule Mapper (SMMAP), a genomic profiling platform for mapping interactions between small molecules and chromatin genome-wide. SMMAP addresses a gap in drug development by providing the first direct method to profile drug-chromatin interactions at scale. Current assays rely on chemical affinity capture or CUT&TAG workflows that lack sensitivity and compatibility with chromatin-associated protein targets. The proposed innovation centers on an immunotethering assay for in situ genomic profiling of small molecule binding, designed to maximize assay sensitivity while maintaining compatibility with transiently interacting targets such as transcription factors. By enabling deeper understanding of a drug's direct molecular targets and downstream responses, SMMAP aims to improve epigenetic drug specificity, reduce development timelines, and accelerate translational research for cancer, inflammation, and neurological disease therapeutics. Performance occurs in Research Triangle Park, Durham, North Carolina, with a period of performance extending from September 1, 2026, through August 31, 2028. The assistance type is a Project Grant, indicating support for a discrete research project with defined deliverables rather than an ongoing program or center.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.1m | 8/18/26 |