Project Grant R44TR005379
- Federal Grant Award Summary Intero Biosystems Inc. received a $349,952 Project Grant from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded on June 20, 2025, with a completion date of June 19, 2026. In collaboration with the University of Michigan, the awardee is developing and validating a novel stem cell-derived human intestinal organoid (HIO) screening platform designed to improve preclinical drug testing and reduce the current 90% failure rate of drug...
- Federal Project Grant Award Summary Intero Biosystems Inc. received a $349,824 Phase I Small Business Innovation Research (SBIR) Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under CFDA 93.350, with an award date of July 15, 2026, and completion date of July 14, 2027. The company will develop a scalable human peristaltic intestinal organoid (Peristaltic-HIO) platform designed to advance drug discovery and preclinical testing for gastrointestinal...
- Federal Grant Award Summary Epitune LLC received a $350,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on September 16, 2025, with completion targeted for February 28, 2026. The award funds development of a novel imaging-based platform for single-cell quality and identity control of human-induced pluripotent stem cells (hiPSCs) and other cell types used in cell-based...
- Federal Grant Award Summary Sinopia Biosciences Inc. received a $350,000 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) awarded August 1, 2025, with completion targeted for July 31, 2026. The award supports the development of neural network models and computational workflows to enable efficient metabolomic characterization of large compound libraries for data-driven drug discovery (D4). Sinopia...
- Federal Project Grant Award Summary Onca Bio, Inc. received a $697,696 Project Grant from the National Center for Advancing Translational Sciences (NCATS) under CFDA 93.350, effective September 15, 2025, through September 14, 2027, to develop segmented in vitro translation (SIVT) technology for expanding peptide library diversity in macrocyclic peptide drug discovery. The project addresses a critical limitation in current mRNA display methods, which restrict cyclization chemistry to two fixed...
- Federal Project Grant Award Summary Integrated Micro-Chromatography Systems, Inc. (IMCS) received a $315,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for the period September 1, 2025 through August 31, 2026. The award supports the development of chemoenzymatic methods and production of glycosphingolipids (GSLs), which are complex carbohydrate-containing lipids found on cell membranes...
- Federal Project Grant Award Summary Columbia University's Health Sciences Division received a $164,500 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective August 19, 2025, with completion targeted for July 31, 2027. The award funds the development and validation of human normal tissue patient-derived organoids (NT-PDOs) established from healthy tissue biopsies to serve as a pre-screening...
- Federal Grant Award Summary Biotherapeutics, Inc. received a $628,726 SBIR Phase 1 Project Grant awarded on August 13, 2025, by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports the development of a novel, host-targeted, antibiotic-sparing oral therapeutic for the concurrent treatment of Clostridioides difficile infection (CDI) and inflammatory bowel disease (IBD). The innovative...
- Federal Grant Award Summary Precision Quantomics, Inc. received a $570,888 Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under CFDA 93.350, with an award date of August 15, 2025 and completion date of August 14, 2026. This Phase I project aims to develop recombinant human enzyme panels that represent genetic variants in drug-metabolizing enzymes present in the U.S. patient population, with particular emphasis on populations carrying less common...
- Federal Project Grant Award Summary Syntr Health Technologies, Inc. received a $1,050,276 Project Grant award from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) on September 25, 2025, with a completion date of August 31, 2027. The award supports the advancement and automation of the company's FDA-cleared SYNTRFUGE system and SYNTRFPU360 microfluidic platform for rapid tissue processing and microsizing. The technology automates tissue dissociation and processing...
Award Details:
Intero Biosystems Inc. received a $1,046,897 Project Grant from the National Center for Advancing Translational Sciences (NCATS), NIH (CFDA 93.350) effective July 1, 2026, through June 30, 2028, to develop and commercialize a novel human intestinal organoid (HIO) screening platform for pharmaceutical drug discovery and preclinical testing. Products and Services:
Under this Phase II award, Intero Biosystems will scale production methods and establish standardized quality control, shelf-life, and cryopreservation benchmarks for its stem cell-derived HIO platform—a multicellular tissue model that incorporates multiple cell types of the native intestine. The company will validate high-throughput screening assays for intestinal toxicity and fibrosis, expand cytotoxicity screening capabilities to detect selective or partial effects on different intestinal cell types, and evaluate antifibrotic efficacy across acute, chronic, and immune-mediated fibrosis models using both FDA-approved and experimental therapies. These deliverables aim to position the HIO platform as a scalable, commercially viable preclinical testing tool that better predicts drug toxicity and efficacy compared to traditional animal models and simple cell monolayers, thereby addressing the critical industry challenge of high drug candidate failure rates in clinical trials.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 7/7/26 |