Novel sensor integrated proteome on chip (spoc) platform for evaluating kinetic parameters of protein interactions in high throughput
Ended Project Grant Awarded Last action
- Award ID
- R44TR004297
- Recipient
-
Spoc Proteomics Inc. UEI QA7ENLFWNZW9
- Awarding agency
-
National Center for Advancing Translational Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $3,427,681
Award facts
- Assistance listing
- 93.350 National Center for Advancing Translational Sciences
- Completion date
- Originally
- Place of performance
- Arizona, USA
Award details come from USAspending.gov.
Description
- Abstract
- A critical bottleneck in the field of proteomics is the inability to simultaneously and cost-effectively evaluate thousands of functional protein interactions at once to obtain kinetic data. Although conventional in-situ protein microarray technology is well developed, IT uses fluorescent DYE based detection that provides only qualitative or semi-quantitative information. There is currently no technology that offers label-free real-time interaction assays of full-length folded proteins in high throughput format. To address this unmet need, inanobio is developing novel sensor integrated proteome on chip (spoc) platform that combines in situ expression and capture of functional proteins on biosensors, to allow instant high throughput analysis of thousands of proteins in real time. In this sbir phase II project, we propose to develop spoc platform by integrating in situ produced protein arrays with surface plasmon resonance imaging (spri), by building integrated prospr instrument that will enable spri determination of both qualitative and kinetic information of protein biomolecular interactions in high throughput. We will develop, validate and apply 1000 protein spoc spri sensor chips to study clinically relevant protein- protein interactions and test off-target binding of new antibodies produced in animal models against human proteins.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $1,070,227 | |
| Amendment | $1,178,727 | |
| Original award | $1,178,727 |
Quick answers
Who received award R44TR004297?
R44TR004297 was awarded to Spoc Proteomics Inc. by National Center for Advancing Translational Sciences (National Institutes of Health) on August 12, 2022.
How much is award R44TR004297 worth?
$3,427,681 has been obligated on R44TR004297.
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