Project Grant R44NS145934
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research by Function Therapeutics Inc. to investigate the use of a new class of small molecule compounds called Parmodulins for the treatment of neuropathic pain. The $499,863 award, granted on September 11, 2025, will fund research to synthesize and test various Parmodulins for their ability to modulate the...
- This $1,511,970 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports the development of selective GPR34 antagonists for the treatment of neuropathic pain. The award aims to identify CNS-active GPR34 hits that can be further developed into novel GPR34 antagonists as potential drug candidates for neuropathic pain. Key products and services include: 1) Synthesis and testing of novel...
- The National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), awarded a $818,360 Cooperative Agreement to the University of Southern California (USC) to develop new highly potent and safe Angiotensin AT2 receptor (AT2R) antagonists for the treatment of neuropathic pain. This 4-year project aims to optimize a novel lead series of AT2R antagonists that have demonstrated better potency and...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $400,000 Project Grant to Navega Therapeutics, Inc., a San Diego-based biotechnology company, under the Drug Abuse and Addiction Research Programs (CFDA 93.279). The funding will support Navega's research and development efforts to advance novel epigenetic gene therapies targeting the voltage-gated sodium channel NAV1.7 for the treatment of chronic pain. This innovative approach aims to transiently repress NAV1.7...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
- This $453,104 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to explore independent ascending spinal pain circuits that transmit pain signals to the brain. The primary focus is on understanding the role of a newly identified subset of spinal projection neurons expressing the GPR83 neuropeptide receptor, in...
- The Project Grant award of $675,107 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to develop novel non-opioid, non-addictive analgesics for treating neuropathic pain. The project, led by Northeastern University, will focus on designing and evaluating "dualsteric modulators" that act as both cannabinoid CB1 receptor...
- This federal Project Grant award for $1,587,553.00 was provided by the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant is focused on developing novel 5-HT3 receptor antagonists for the treatment of neuropathic pain. The key objectives are to: 1) use computational drug design approaches to identify novel 5-HT3 receptor antagonist chemotypes with potential for central nervous system (CNS) penetration and...
- This federal Project Grant award of $231,000.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to overcome challenges in targeting specific acid-sensing ion channel (ASIC) subunits and heteromers for analgesic treatments. The key products and services to be delivered include: 1) Identifying a novel binding site for the ASIC3 inhibitor ApetxT2 using...
- This $429,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of Schwann cell PIEZO1 in pain sensation. The key objectives are to: 1) develop and validate adeno-associated virus (AAV) vectors for selective inhibition of Schwann cell PIEZO1, and 2) determine the sensory effects of Schwann cell...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting the development of a novel non-opioid peptide therapeutic called ASCT-83 for treating neuropathic pain. The $0.00 award to Alcamena Stem Cell Therapeutics, LLC, a small disadvantaged business located in Halethorpe, MD, aims to determine the safety and tolerability of ASCT-83, establish its reproductive and clinical safety, and derisk the asset for potential partnership with a pharmaceutical company. ASCT-83 is a first-in-class peptide therapeutic that targets the epigenetic mechanisms underlying the transition from acute to chronic neuropathic pain by promoting degradation of the REST transcription factor to restore normal neural gene expression.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | ($1m) | 9/8/25 | ||
| Not listed | $1.5m | 8/7/25 |