Project Grant R44NS127692
- This NSF Engineering Program award of $605,320 to North Carolina State University (NC State) supports the development of a flexible, FMRI-compatible neural probe with multi-modal sensing and modulation capabilities. The novel probe is designed to advance understanding of neural circuit dynamics and enable closed-loop neuromodulation for treating neurological disorders. Key product elements include: Flexible, multi-shank neural probe fabricated using polymeric materials to enable deep brain...
- This $275,000 project grant from the National Science Foundation's Engineering Directorate (CFDA 47.041) will fund the development of novel electronic-photonic silicon carbide neural probes for recording and stimulating neural activity. The Georgia Tech Research Corporation will receive funding on behalf of collaborating researchers to design penetrating neural probes made entirely of silicon carbide, a robust material proven to withstand the corrosive brain environment long-term. The probes...
- This Small Business Innovation Research (SBIR) Phase I project, awarded by the National Science Foundation (NSF) under the TIP (Technology, Innovation, and Partnerships) program (CFDA 47.084), aims to develop a novel, multifunctional neural probe for advancing neuroscience research. The $254,456 grant awarded to Neurobionics Inc. on August 15, 2024, will fund the integration of electrical, optical, and chemical capabilities into a single implantable device. This versatile tool will enable...
- This Project Grant award from the National Science Foundation (CFDA 47.074 Biological Sciences) is for the development of a piezoelectric inchworm machine to enable automated implantation of miniaturized flexible microelectrodes into the brain for large-scale chronic neural recordings. The $499,991 award will fund the development of the inchworm insertion mechanism and its integration with a 3D-printed skull cap platform. This system aims to address the challenges of electrode buckling and...
- This $566,015 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), supports the University of Utah's development of a configurable and thermo-responsive intracortical electrode array platform using 3D printing and gallium-based liquid metal electrode materials. The goal is to create a next-generation implantable neural...
- Purdue University was awarded a $1,304,216 Project Grant by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to develop and test a new platform for high-density 3D electrophysiology and two-photon calcium imaging in freely moving animals. The goal is to enable simultaneous recording of millisecond electrical dynamics and spatial mapping of neural circuit activity during natural behaviors to better understand how the brain processes...
- This $1,417,500 Project Grant awarded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) funds the development of "Electrified Cryo-EM", a novel tool that can kinetically trap biological systems in their metastable, non-equilibrium states. The research aims to unravel the structural changes in neurons during an action potential across multiple length scales, from voltage-gated channel proteins to the synaptic junction. Specifically,...
- This NSF Engineering program Project Grant award to Brown University, totaling $383,560, will support the development of a large-scale wireless network of microchip sensors for monitoring physiological signals and brain activity. The overarching goal is to create an "all-in-one" approach to build a wireless network of thousands of sub-millimeter size sensors that can efficiently transmit and decode sparse event-driven signals, taking inspiration from the brain's neural activity. The...
- This CAREER award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) funds the development of an artificial nervous system enabling in-body communication between wearable and implantable bioelectronic devices. Awarded to Georgia TECH Research Corp on June 15, 2025, with $499,896 obligated through May 31, 2030, the project addresses critical limitations in existing therapeutic systems by creating optimized emitter and receiver networks that facilitate real-time...
- The National Science Foundation (NSF) has awarded a $330,000 Project Grant under the Engineering program (CFDA 47.041) to Yale University. The "NeroFlex" project aims to develop an advanced implantable neural interface platform that integrates optimized resistive RAM memory, programmable analog front-end circuits, and specialized processors for efficient brain data acquisition and computational processing. The research plan encompasses device fabrication, mixed-signal circuit design,...
COMMERCIALIZATION OF INTEGRATED ELECTRODE-ELECTRONICS SYSTEM FOR LARGE SCALE, LONG-LASTING ELECTROPHYSIOLOGY - PROJECT SUMMARY EXAMINING HOW BEHAVIOR ARISES FROM THE COMPLEX INTERCONNECTED ACTIVITY OF THE BRAIN IS A CORNERSTONE OF NEUROSCIENCE RESEARCH. A RECENT TECHNOLOGICAL ADVANCE IN NEUROTECHNOLOGY IS ENABLING STUDIES WHERE THE PARALLEL ACTIVITY OF THOUSANDS OF NEURONS CAN BE STUDIED IN RODENT BRAINS. THE NEUROPIXELS PROBE, ALLOWING 384 CHANNELS OF ELECTROPHYSIOLOGICAL DATA TO BE OBSERVED FROM THE BRAIN, IS NOW A VALUABLE TOOL FOR NEXT-GENERATION EXPERIMENTS. ONE GOAL OF THIS PROJECT IS TO PROVIDE A COMMERCIAL ALTERNATIVE TO THE NEUROPIXELS PROBE AND ASSOCIATED ELECTRONICS THAT WILL ENABLE FEATURE PARITY IN RECORDING CAPABILITY, BUT ALSO BE USABLE IN SCIENTIFIC APPLICATIONS CURRENTLY UNADDRESSED BY THE EXISTING NEUROPIXELS PROBE. OUR PROPOSED SOLUTION IS PARTIALLY ENABLED BY THE MAKERS OF THE NEUROPIXLES PROBES-IMEC HAS RECENTLY MADE COMMERCIALLY AVAILABLE THE ELECTRONICS OF THE PROBES AS A STANDALONE 384 CHANNEL CHIP WITHOUT THE SILICON ELECTRODES ATTACHED. BY CONNECTING THIS PROVEN TECHNOLOGY TO A NEW TYPE OF ELECTRODE ARRAY-FLEXIBLE POLYIMIDE-BASED PROBES-WE OUTLINE A STRATEGY TO OFFER TECHNOLOGY WITH SIMILAR CHANNEL DENSITY THAT IS 1) IS RESISTANT TO BREAKAGE UPON INSERTION, 2) ENABLES CLOSELY-SPACED IMPLANTATION SITES, AND 3) HAS A SIGNIFICANT REDUCTION IN GLIAL SCARRING COMPARED TO SILICON PROBES, ENABLING EXTREMELY STABLE RECORDINGS FOR MONTHS. FURTHERMORE, BY COUPLING THIS PROBE TO POWERFUL DATALOGGING ELECTRONICS, WE WILL OFFER A WAY TO SCALE CHANNEL COUNTS TO ABOVE 3000 WITHOUT THE NEED FOR CABLES BETWEEN THE ANIMAL AND A COMPUTER.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 3/5/26 | ||
| Not listed | $360.0k | 7/30/24 | ||
| Not listed | $292.8k | 9/8/23 | ||
| Not listed | ($293k) | 9/8/23 | ||
| Not listed | $360.0k | 8/2/23 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
0822MNS | Regents Of The University Of Minnesota | Project Grant R44NS127692 | $47.3k | 10/29/24 | |
0822RUS | William Marsh Rice University | Project Grant R44NS127692 | $201.9k | 10/29/24 | |
0822SFS | The Regents Of The University Of California. San Francisco | Project Grant R44NS127692 | $33.8k | 10/29/24 |