Commercialization of integrated electrode-electronics system for large scale, long-lasting electrophysiology
Ended Project Grant Awarded Last action
- Award ID
- R44NS127692
- Recipient
-
Spikegadgets, Inc. UEI KKNKANJQJJA5
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $2,896,837
Award facts
- Assistance listing
- 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health
- Completion date
- Funding agency
- National Institute of Biomedical Imaging and Bioenginering National Institutes of Health, Department of Health and Human Services
- Place of performance
- California, USA
Award details come from USAspending.gov.
Description
- Abstract
- Examining how behavior arises from the complex interconnected activity of the brain is a cornerstone of neuroscience research. A recent technological advance in neurotechnology is enabling studies where the parallel activity of thousands of neurons can be studied in rodent brains. The neuropixels probe, allowing 384 channels of electrophysiological data to be observed from the brain, is now a valuable tool for next-generation experiments. One goal of this project is to provide a commercial alternative to the neuropixels probe and associated electronics that will enable feature parity in recording capability, but also be usable in scientific applications currently unaddressed by the existing neuropixels probe. Our proposed solution is partially enabled by the makers of the neuropixles probes-imec has recently made commercially available the electronics of the probes as a standalone 384 channel chip without the silicon electrodes attached. By connecting this proven technology to a new type of electrode array-flexible polyimide-based probes-we outline a strategy to offer technology with similar channel density that is 1) is resistant to breakage upon insertion, 2) enables closely-spaced implantation sites, and 3) has a significant reduction in glial scarring compared to silicon probes, enabling extremely stable recordings for months. Furthermore, by coupling this probe to powerful datalogging electronics, we will offer a way to scale channel counts to above 3000 without the need for cables between the animal and a computer.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $360,033 | |
| Amendment | $292,804 | |
| Amendment | -$292,804 | |
| Amendment | $360,033 | |
| Amendment | $360,033 | |
| Amendment | $360,033 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
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| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $360,033 | |
| Amendment | $548,336 | |
| Original award | $548,336 |
Show all 18
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Regents Of The University Of Minnesota | $205,311 | |
| William Marsh Rice University | $609,817 | |
| The Regents Of The University Of California. San Francisco | $98,352 |
Quick answers
Who received award R44NS127692?
R44NS127692 was awarded to Spikegadgets, Inc. by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on July 1, 2022.
How much is award R44NS127692 worth?
$2,896,837 has been obligated on R44NS127692.
Which agency awarded R44NS127692?
National Institute of Neurological Disorders and Stroke (National Institutes of Health) awarded R44NS127692, with funding from National Institute of Biomedical Imaging and Bioenginering (National Institutes of Health).
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