Project Grant R44MH142264
- This Project Grant award, valued at $120,015.00, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award supports research by the President and Fellows of Harvard College to develop a novel technological pipeline that enables the monitoring of large-scale neural activity in freely moving animals and the identification of the transcriptomic identity of the same individual neurons. This research aims to achieve a...
- This Project Grant award of $517,546, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to optimize, benchmark, and validate a novel multimodal microelectrode array (MEA) probe that integrates fast-scan cyclic voltammetry (FSCV) for sub-second neuromodulator sensing with parallel electrical recording. The research team, led by investigators from Dartmouth College, aims to develop this integrated MEA platform...
- The National Institute of Mental Health (NIMH) awarded a $980,661 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Neuralthread Inc. to develop a fully integrated "TULLEKIT" system for stable, high-density neural recordings in freely moving non-human primates (NHPs). The TULLEKIT platform combines ultraflexible 384-channel probes, a minimally invasive port system for deep-brain implantation, and a wireless recording headstage to address key challenges in...
- This $449,228 Project Grant from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will enable Neuronexus Technologies, Inc. (doing business as Nuvectra) to develop an integrated system for large-scale, chronic extracellular neural recording and stimulation in human brain organoids. The project aims to 1) create advanced biological assay chambers to support chronic electrophysiology while maintaining organoid health, 2) develop...
- The National Institute of Mental Health (NIMH) awarded a $505,311 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Intelligent Imaging Innovations, Inc. (3i), a for-profit manufacturer of advanced microscopy equipment and software based in Denver, Colorado. The two-year grant, awarded on January 1, 2025, seeks to establish the feasibility of combining recent advances in optical techniques to produce a commercial instrument that enables large-scale, all-optical...
- This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $537,650 to Spike Neuro LLC for the development of a flexible carbon fiber penetrating nerve cuff and cortical array for neural recording, stimulation, and neurochemical detection. The project aims to create advanced electrophysiology recording and stimulation tools...
- Purdue University was awarded a $1,304,216 Project Grant by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to develop and test a new platform for high-density 3D electrophysiology and two-photon calcium imaging in freely moving animals. The goal is to enable simultaneous recording of millisecond electrical dynamics and spatial mapping of neural circuit activity during natural behaviors to better understand how the brain processes...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $659,217 to develop a novel microelectrode sensor to continuously measure endogenous neuropeptide Y (NPY) release in brain tissue and single cells. The primary objective is to enhance detection of NPY, a key neuropeptide implicated in neurological disorders, by optimizing an existing NPY biosensor to improve sensitivity and selectivity while...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to develop an integrated, portable sensor suite for concurrent recording of neural activity, physiological arousal, motor signals, and physical interactions in social environments. The $1,453,943 award will fund research to integrate neural oscillatory features of visual attention with additional sensors to extract physiological and movement-derived...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will provide $2,565,783 to Oregon Health & Science University (OHSU) from September 1, 2023 to August 31, 2026 to develop novel genetically encoded sensors and actuators for monitoring and manipulating neuromodulatory signaling activities in the brain at the cellular and circuit levels. The project aims to enable large-scale in vivo...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is for the development and commercialization of an automated platform for high-throughput behavioral and electrophysiology research in freely behaving rats. The $1,266,318 award to Spikegadgets, Inc., a neuroscience research equipment company based in San Francisco, CA, will fund the creation of an integrated system that can administer operant behavioral protocols, wirelessly record spiking activity from hundreds of electrodes, and operate continuously with minimal human intervention. This platform aims to enable more efficient study of neural activity and behavior while overcoming the challenges of inter-subject variability. The 3-year project period runs from August 1, 2025 to July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 8/1/25 |