Commercialization of a rapid, automated HI-C platform for sensitive genomic profiling of multiple cancer sample types
Ended Project Grant Awarded Last action
- Award ID
- R44HG014126
- Recipient
-
Cantata Bio LLC UEI F4QRHMMF3CC8
- Awarding agency
-
National Human Genome Research Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,993,708
Award facts
- Assistance listing
- 93.172 Human Genome Research
- Completion date
- Place of performance
- Santa Cruz, CA 95066, USA
Award details come from USAspending.gov.
Description
- Abstract
- Cancer is projected to affect 20M people worldwide in 2023, with new cases increasing almost 30% in the next two decades. Cancer is a complex disease caused by a vast range of genetic and epigenetic defects. Existing technologies often fall short in comprehensively identifying the various genetic aberrations underlying different cancer types. A significant number of cancers remain without detected actionable or causative variants, revealing a critical GAP in our understanding, and delaying or preventing the use of targeted treatments. To address this GAP, we have developed an innovative HI-C workflow that we call varilink™. Varilink overcomes many of the limitations of current genomic technologies and substantially enhances the detection of cancer- driving structural variants (SVS) in the genome. By leveraging the 3D structure of the genome to incorporate long-range linkage information into the sequencing library, varilink enables highly sensitive detection of large SVS, while maintaining shotgun-like detection of smaller variants such as small nucleotide variants (SNVS) and insertions/deletions (INDELS). Varilink also overcomes the drawbacks of other commercially available HI-C technologies with its 1) rapid workflow (
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $746,680 | |
| Original award | $1,247,028 |
Quick answers
Who received award R44HG014126?
R44HG014126 was awarded to Cantata Bio LLC by National Human Genome Research Institute (National Institutes of Health) on September 18, 2024.
How much is award R44HG014126 worth?
$1,993,708 has been obligated on R44HG014126.
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