Project Grant R44HG011060

This Project Grant award from the National Institutes of Health's National Human Genome Research Institute provided $768,678 to Molecular Assemblies, Inc. to develop a fully enzymatic oligonucleotide synthesis cycle using engineered template-independent polymerases and a novel phosphate dNTP blocking group. The award supports the goals of the Human Genome Research program (CFDA 93.172) to accelerate genome research and its application to human health. Specifically, the awardee will engineer...

Sequegenics LLC received a $251,073 Project Grant award from the National Science Foundation Division of Industrial Innovation under the Engineering federal grant program (CFDA 47.041). The grant supports development of low-cost and scalable methods for creating genomic databases using long-read next-generation DNA sequencing technologies. This aligns with the program's goals of fostering innovation in engineering research. The one-year project period runs from August 1, 2021 through July 31,...

Federal Grant Award Summary: SPINSEQ Project Electronic Biosciences, Inc. received a Phase I Small Business Innovation Research (SBIR) Project Grant of $383,482 from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded on June 6, 2025, with a completion date of May 31, 2027. The company is developing SPINSEQ, an innovative RNA sequencing platform designed to deliver precise and accurate transcriptomic analysis while preserving RNA...

Armonica Technologies, Inc. was awarded a $1,047,600 Project Grant from the National Human Genome Research Institute of the Department of Health and Human Services to develop a novel DNA sequencing platform. The award was made under the Human Genome Research program (CFDA 93.172), which supports technologies to accelerate genomic research and its application to human health. Specifically, Armonica will use the funding to optimize a metal-insulator-metal structure for single base sensitivity...

The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded Evizia Inc. a $1,234,692 Project Grant on April 7, 2025 to develop a novel instrument and consumables for quality control in next-generation sequencing (NGS). The award supports Evizia's PRECYSE biomolecule desktop imaging system, which utilizes high-speed atomic force microscopy to provide rapid, sensitive, and cost-effective quality control for NGS sample...

Micropure Genomics Inc. received a $274,199 Project Grant award from the National Science Foundation to advance methods for rapid, end-to-end sample preparation for sequencing applications. Under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), the company will develop an automated process relying on electro-hydrodynamic trapping to isolate genomic material like DNA or RNA from cells in a flow cartridge. The process aims to significantly reduce preparation time while...

Electronic Biosciences, Inc. received a $350,000 Phase I Small Business Technology Transfer (STTR) project grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on June 1, 2025, with a completion date of May 31, 2027. The company, in collaboration with Distinguished Professor Cynthia J. Burrows, is developing the first high-accuracy sequencing technology capable of simultaneously detecting...

This $256,000 National Science Foundation Engineering grant supports the development of an easy RNA adenylation method for deep sequencing of picogram RNA samples with high resolution. Specifically, Ezrabio Inc. will develop a versatile and cost-effective library construction technology that enables protein translation monitoring on a variety of biological samples. The proposed technology relies on a novel enzyme system capable of 5' adenylation and 3' polyadenylation of RNA fragments to...

This $600,000 Project Grant from the National Science Foundation's Computer and Information Science and Engineering program will fund research at the University of Texas at Austin to develop DNA-based storage and computation techniques. Specifically, the award supports the creation of a "SIMD-DNA" paradigm that uses strand displacement reactions to manipulate digital data encoded in the topological structure of DNA. This approach aims to enable parallel, in-memory computation without...

This $639,794 federal grant award from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) supports the acquisition of an Illumina NextSeq 2000 next-generation DNA sequencing instrument for the Design, Automation, Manufacturing, and Process (DAMP) Laboratory at Boston University. The new sequencing instrument will enable DAMP Lab researchers to study the genomic sequences of novel molecular tools they are developing, which can lead to improvements in drug design,...