Project Grant R44HG009875

This $467,334 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop an automated pipeline for generating machine learning-ready RNA motif feature datasets to enhance RNA structure prediction and analysis. The key products and services to be delivered under this 3-year award include: An automated framework to parse RNA motif structures and generate AI/ML-ready datasets....

This Project Grant from the National Science Foundation Division of Emerging Frontiers, under the Biological Sciences federal grant program (CFDA 47.074), provides $932,563 to support research into the discovery of novel functional RNA classes through computational integration of massively parallel RNA-binding protein binding and structure data. The President and Fellows of Harvard College will utilize highly multiplexed approaches to generate transcriptome-wide measurements of hundreds of...

This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $750,000 to Stanford University to develop new technologies for studying RNA, the essential molecules that carry genetic information and play crucial roles in cell functions. The key products and services to be delivered under this 3-year award include: Creating non-destructive methods to directly study RNA localization and interactions within living cells, achieving...

This $256,000 National Science Foundation Engineering grant supports the development of an easy RNA adenylation method for deep sequencing of picogram RNA samples with high resolution. Specifically, Ezrabio Inc. will develop a versatile and cost-effective library construction technology that enables protein translation monitoring on a variety of biological samples. The proposed technology relies on a novel enzyme system capable of 5' adenylation and 3' polyadenylation of RNA fragments to...

The National Institute of General Medical Sciences (NIGMS) awarded a $305,892 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Dotquant LLC, a biotechnology research and development company, to develop a new in vitro transcription kit for high-yield synthesis of chemically modified RNA. The project aims to combine the benefits of wild-type T7 RNA polymerase, which has high efficiency and low cost, with the ability of mutant T7 RNA polymerases to...

This $750,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of a novel platform to enable rapid and robust identification of functional RNA molecules directly within mammalian cellular environments. The research aims to solve the challenge of RNA structure sensitivity to local environments that has hindered progress in the field of functional RNA discovery. The project will deliver a customized...

This $469,407 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), will fund research to discover novel functional RNA classes through computational integration of massively parallel RNA-binding protein binding and structure data. The awardee, Georgia Tech Research Corporation, will conduct this research from March 2023 through February 2028. Specifically, the organization will...

This $1,042,995 National Science Foundation project grant, awarded on March 15, 2023 under the Biological Sciences (47.074) program, funds research at Oregon State University and Mount Holyoke College to discover novel functional RNA classes through computational integration of massively parallel RNA-binding protein binding and structure data. The grantees will develop new experimental and computational methods to systematically identify unknown non-coding RNA classes by combining known and...

This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), provides $383,482 to Electronic Biosciences, Inc. to develop SPINSEQ, an innovative RNA sequencing platform. The goal is to create a highly precise and accurate technology that can detect critical RNA modifications, overcoming limitations of existing RNA sequencing methods. During this Phase I project, the company will focus on developing and optimizing the...

This $3.7 million project grant from the National Institutes of Health's National Institute of Biomedical Imaging and Bioengineering will fund research at Arizona State University to develop RNA stabilizing elements that improve coronavirus diagnostics. Specifically, the university will model the role of 5' secondary structures in modulating mRNA stability, optimize sensing RNAs to detect SARS-CoV-2, and use degradable trans-acting RNAs to enhance sample and amplified RNA stability....