Project Grant R44HD092156

The National Institute of Child Health and Human Development (NICHD) awarded a $1,708,120 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Baylor College of Medicine to develop biomimetic intervention strategies for endogenous in utero repair of spina bifida, a devastating neural tube defect. The project aims to devise less invasive approaches for in utero repair of spina bifida by creating a pro-regenerative environment within the amniotic cavity to...

This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) totaling $1,459,877 will support research to develop a bioinspired composite scaffold for repairing pubovisceral muscle enthesis (PVME) injuries, which can lead to pelvic organ prolapse in women. The research will involve three main components: Investigating the structure and function of native PVME and...

This $848,100 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research, supports research to examine the cellular and tissue-level changes in the vagina of women with recurrent pelvic organ prolapse (POP) after previous POP surgery. The primary objectives are to: 1) Assess the effect of POP surgery on the biomechanical properties, histology, and molecular profiles of the human...

This Project Grant award, valued at $606,518 and funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to develop and test the safety and feasibility of spermatogonial stem cell (SSC) transplantation and testicular tissue grafting procedures for restoring fertility in patients who previously cryopreserved their testicular tissues. The awardee, Magee-Womens Research...

This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $1,963,122 to the University of Missouri System to conduct research on the molecular mechanisms regulating uterine development. The research aims to define critical physiological and genetic pathways that regulate uterine development, function, and regeneration in order to diagnose, treat, and prevent...

This $516,556 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program aims to develop and validate a novel, personalized flow modeling paradigm for assessing hemodynamics of the fetal aorta. The project, conducted by Worcester Polytechnic Institute (WPI), will focus on coarctation of the aorta, a common congenital heart...

This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is focused on engineering the fetal environment to enable in-utero treatment of spina bifida bone defects. The $600,475 award to the University of California, Davis will support the development of a collagen-based scaffold modified with specific integrin ligands and placental mesenchymal...

This Project Grant award of $608,507 from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports the development, implementation, and evaluation of a training program on the treatment of health complications due to female genital mutilation/cutting (FGM/C) in Tanzania. The key products and services to be delivered through this 5-year award include: 1) conducting a social ecological needs assessment to...

This federal Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $215,250 to the Veterans Medical Research Foundation of San Diego to conduct research on preventing anal sphincter dysfunction after childbirth-related neuromuscular injury. The key objectives of the research are to evaluate the efficacy of a novel brain-derived neurotrophic factor (BDNF) sustained-release...

This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $328,496 to Pelva Health Corporation to develop a novel hydrogel film and applicator delivery system to reduce pain experienced during sexual intercourse for women with vulvodynia. The goal is to create a non-pharmaceutical solution that can help mitigate pain receptor activity and allow for...